Uncovering the assembly pathway of human ribosomes and its emerging links to disease

The essential cellular process of ribosome biogenesis is at the nexus of various signalling pathways that coordinate protein synthesis with cellular growth and proliferation. The fact that numerous diseases are caused by defects in ribosome assembly underscores the importance of obtaining a detailed...

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Autores principales: Bohnsack, Katherine E, Bohnsack, Markus T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600647/
https://www.ncbi.nlm.nih.gov/pubmed/31268599
http://dx.doi.org/10.15252/embj.2018100278
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author Bohnsack, Katherine E
Bohnsack, Markus T
author_facet Bohnsack, Katherine E
Bohnsack, Markus T
author_sort Bohnsack, Katherine E
collection PubMed
description The essential cellular process of ribosome biogenesis is at the nexus of various signalling pathways that coordinate protein synthesis with cellular growth and proliferation. The fact that numerous diseases are caused by defects in ribosome assembly underscores the importance of obtaining a detailed understanding of this pathway. Studies in yeast have provided a wealth of information about the fundamental principles of ribosome assembly, and although many features are conserved throughout eukaryotes, the larger size of human (pre‐)ribosomes, as well as the evolution of additional regulatory networks that can modulate ribosome assembly and function, have resulted in a more complex assembly pathway in humans. Notably, many ribosome biogenesis factors conserved from yeast appear to have subtly different or additional functions in humans. In addition, recent genome‐wide, RNAi‐based screens have identified a plethora of novel factors required for human ribosome biogenesis. In this review, we discuss key aspects of human ribosome production, highlighting differences to yeast, links to disease, as well as emerging concepts such as extra‐ribosomal functions of ribosomal proteins and ribosome heterogeneity.
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spelling pubmed-66006472019-07-12 Uncovering the assembly pathway of human ribosomes and its emerging links to disease Bohnsack, Katherine E Bohnsack, Markus T EMBO J Review The essential cellular process of ribosome biogenesis is at the nexus of various signalling pathways that coordinate protein synthesis with cellular growth and proliferation. The fact that numerous diseases are caused by defects in ribosome assembly underscores the importance of obtaining a detailed understanding of this pathway. Studies in yeast have provided a wealth of information about the fundamental principles of ribosome assembly, and although many features are conserved throughout eukaryotes, the larger size of human (pre‐)ribosomes, as well as the evolution of additional regulatory networks that can modulate ribosome assembly and function, have resulted in a more complex assembly pathway in humans. Notably, many ribosome biogenesis factors conserved from yeast appear to have subtly different or additional functions in humans. In addition, recent genome‐wide, RNAi‐based screens have identified a plethora of novel factors required for human ribosome biogenesis. In this review, we discuss key aspects of human ribosome production, highlighting differences to yeast, links to disease, as well as emerging concepts such as extra‐ribosomal functions of ribosomal proteins and ribosome heterogeneity. John Wiley and Sons Inc. 2019-05-14 2019-07-01 /pmc/articles/PMC6600647/ /pubmed/31268599 http://dx.doi.org/10.15252/embj.2018100278 Text en © 2019 The Authors. Published under the terms of the CC BY NC ND 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Bohnsack, Katherine E
Bohnsack, Markus T
Uncovering the assembly pathway of human ribosomes and its emerging links to disease
title Uncovering the assembly pathway of human ribosomes and its emerging links to disease
title_full Uncovering the assembly pathway of human ribosomes and its emerging links to disease
title_fullStr Uncovering the assembly pathway of human ribosomes and its emerging links to disease
title_full_unstemmed Uncovering the assembly pathway of human ribosomes and its emerging links to disease
title_short Uncovering the assembly pathway of human ribosomes and its emerging links to disease
title_sort uncovering the assembly pathway of human ribosomes and its emerging links to disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600647/
https://www.ncbi.nlm.nih.gov/pubmed/31268599
http://dx.doi.org/10.15252/embj.2018100278
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