Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice

The author previously reported that short‐duration intermittent hypoxia had additive effects on improvements in endurance capacity by enhancing fatty acid metabolism. The present study was designed to investigate the effects of short‐duration intermittent hypoxia on endurance capacity, metabolic enz...

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Autor principal: Suzuki, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643079/
https://www.ncbi.nlm.nih.gov/pubmed/31328438
http://dx.doi.org/10.14814/phy2.14182
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author Suzuki, Junichi
author_facet Suzuki, Junichi
author_sort Suzuki, Junichi
collection PubMed
description The author previously reported that short‐duration intermittent hypoxia had additive effects on improvements in endurance capacity by enhancing fatty acid metabolism. The present study was designed to investigate the effects of short‐duration intermittent hypoxia on endurance capacity, metabolic enzyme activity, and protein levels associated with mitochondrial biogenesis in well‐trained mice. Mice in the training group were housed in a cage with a running wheel for 7 weeks from 5 weeks old. Voluntary running markedly increased maximal work values by 5.0‐fold. Trained mice were then subjected to either endurance treadmill training (ET) for 60 min or hybrid training (HT, ET for 30 min followed by sprint interval exercise (5‐sec run‐10‐sec rest) for 30 min) with (H‐ET or H‐HT) or without (ET or HT) short‐duration intermittent hypoxia (4 cycles of 12–13% O(2) for 15 min and 20.9% O(2) for 10 min) for 4 weeks. Maximal endurance capacity was markedly greater in the H‐ET and H‐HT than ET and HT groups, respectively. H‐ET and H‐HT increased activity levels of 3‐hydroxyacyl‐CoA‐dehydrogenase in oxidative muscle portion and pyruvate dehydrogenase complex in glycolytic muscle portion. These activity levels were significantly correlated with maximal endurance capacity. Protein levels of dynamin‐related protein‐1 were increased more by H‐ET and H‐HT than by ET and HT, but were not significantly correlated with maximal work. These results suggest that intermittent hypoxic exposure has beneficial effects on endurance and hybrid training to improve the endurance capacity via improving fatty acid and pyruvate oxidation in highly trained mice.
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spelling pubmed-66430792019-07-30 Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice Suzuki, Junichi Physiol Rep Original Research The author previously reported that short‐duration intermittent hypoxia had additive effects on improvements in endurance capacity by enhancing fatty acid metabolism. The present study was designed to investigate the effects of short‐duration intermittent hypoxia on endurance capacity, metabolic enzyme activity, and protein levels associated with mitochondrial biogenesis in well‐trained mice. Mice in the training group were housed in a cage with a running wheel for 7 weeks from 5 weeks old. Voluntary running markedly increased maximal work values by 5.0‐fold. Trained mice were then subjected to either endurance treadmill training (ET) for 60 min or hybrid training (HT, ET for 30 min followed by sprint interval exercise (5‐sec run‐10‐sec rest) for 30 min) with (H‐ET or H‐HT) or without (ET or HT) short‐duration intermittent hypoxia (4 cycles of 12–13% O(2) for 15 min and 20.9% O(2) for 10 min) for 4 weeks. Maximal endurance capacity was markedly greater in the H‐ET and H‐HT than ET and HT groups, respectively. H‐ET and H‐HT increased activity levels of 3‐hydroxyacyl‐CoA‐dehydrogenase in oxidative muscle portion and pyruvate dehydrogenase complex in glycolytic muscle portion. These activity levels were significantly correlated with maximal endurance capacity. Protein levels of dynamin‐related protein‐1 were increased more by H‐ET and H‐HT than by ET and HT, but were not significantly correlated with maximal work. These results suggest that intermittent hypoxic exposure has beneficial effects on endurance and hybrid training to improve the endurance capacity via improving fatty acid and pyruvate oxidation in highly trained mice. John Wiley and Sons Inc. 2019-07-21 /pmc/articles/PMC6643079/ /pubmed/31328438 http://dx.doi.org/10.14814/phy2.14182 Text en © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Suzuki, Junichi
Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
title Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
title_full Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
title_fullStr Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
title_full_unstemmed Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
title_short Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
title_sort effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643079/
https://www.ncbi.nlm.nih.gov/pubmed/31328438
http://dx.doi.org/10.14814/phy2.14182
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