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Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol

BACKGROUND: Our study shows that a membrane sealant/fiber fusogen polyethylene glycol (PEG) applied immediately on a sharp section of the spinal cord can mend the cord and lead to exceptional levels of motor recovery, with some animals almost normal. MATERIALS AND METHODS: Before deploying such tech...

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Autores principales: Ren, Shuai, Liu, Zehan, Kim, C. Yoon, Fu, Kuang, Wu, Qiong, Hou, Liting, Sun, Linlin, Zhang, Jian, Miao, Qing, Kim, Jin, Bonicalzi, Vincenzo, Guan, Xiangchen, Zhang, Mingzhe, Zhang, Weihua, Xu, Junfeng, Canavero, Sergio, Ren, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743687/
https://www.ncbi.nlm.nih.gov/pubmed/31528388
http://dx.doi.org/10.25259/SNI-73-2019
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author Ren, Shuai
Liu, Zehan
Kim, C. Yoon
Fu, Kuang
Wu, Qiong
Hou, Liting
Sun, Linlin
Zhang, Jian
Miao, Qing
Kim, Jin
Bonicalzi, Vincenzo
Guan, Xiangchen
Zhang, Mingzhe
Zhang, Weihua
Xu, Junfeng
Canavero, Sergio
Ren, Xiaoping
author_facet Ren, Shuai
Liu, Zehan
Kim, C. Yoon
Fu, Kuang
Wu, Qiong
Hou, Liting
Sun, Linlin
Zhang, Jian
Miao, Qing
Kim, Jin
Bonicalzi, Vincenzo
Guan, Xiangchen
Zhang, Mingzhe
Zhang, Weihua
Xu, Junfeng
Canavero, Sergio
Ren, Xiaoping
author_sort Ren, Shuai
collection PubMed
description BACKGROUND: Our study shows that a membrane sealant/fiber fusogen polyethylene glycol (PEG) applied immediately on a sharp section of the spinal cord can mend the cord and lead to exceptional levels of motor recovery, with some animals almost normal. MATERIALS AND METHODS: Before deploying such technology in man, long-term data in large mammals that exclude delayed complications (e.g., central pain), confirm the stability of motor recovery, and provide histological evidence of fiber regrowth are necessary. Here, we provide such evidence in dogs followed up over 6 months and in 2 cases up to 1 year along with imaging and histologic data. RESULTS: We show that dogs whose dorsal cord has been fully transected recover locomotion after immediate treatment with a fusogen (PEG). No pain syndrome ensued over the long term. Diffusion tensor imaging magnetic resonance and histological, including immunohistochemical, data confirmed the re-establishment of anatomical continuity along with interfacial axonal sprouting. CONCLUSIONS: This study proves that a form of irreversible spinal cord injury (SCI) can effectively be treated and points out a way to treat SCI patients.
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spelling pubmed-67436872019-09-16 Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol Ren, Shuai Liu, Zehan Kim, C. Yoon Fu, Kuang Wu, Qiong Hou, Liting Sun, Linlin Zhang, Jian Miao, Qing Kim, Jin Bonicalzi, Vincenzo Guan, Xiangchen Zhang, Mingzhe Zhang, Weihua Xu, Junfeng Canavero, Sergio Ren, Xiaoping Surg Neurol Int Histological and DTI Findings BACKGROUND: Our study shows that a membrane sealant/fiber fusogen polyethylene glycol (PEG) applied immediately on a sharp section of the spinal cord can mend the cord and lead to exceptional levels of motor recovery, with some animals almost normal. MATERIALS AND METHODS: Before deploying such technology in man, long-term data in large mammals that exclude delayed complications (e.g., central pain), confirm the stability of motor recovery, and provide histological evidence of fiber regrowth are necessary. Here, we provide such evidence in dogs followed up over 6 months and in 2 cases up to 1 year along with imaging and histologic data. RESULTS: We show that dogs whose dorsal cord has been fully transected recover locomotion after immediate treatment with a fusogen (PEG). No pain syndrome ensued over the long term. Diffusion tensor imaging magnetic resonance and histological, including immunohistochemical, data confirmed the re-establishment of anatomical continuity along with interfacial axonal sprouting. CONCLUSIONS: This study proves that a form of irreversible spinal cord injury (SCI) can effectively be treated and points out a way to treat SCI patients. Scientific Scholar 2019-03-26 /pmc/articles/PMC6743687/ /pubmed/31528388 http://dx.doi.org/10.25259/SNI-73-2019 Text en Copyright: © 2019 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Histological and DTI Findings
Ren, Shuai
Liu, Zehan
Kim, C. Yoon
Fu, Kuang
Wu, Qiong
Hou, Liting
Sun, Linlin
Zhang, Jian
Miao, Qing
Kim, Jin
Bonicalzi, Vincenzo
Guan, Xiangchen
Zhang, Mingzhe
Zhang, Weihua
Xu, Junfeng
Canavero, Sergio
Ren, Xiaoping
Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol
title Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol
title_full Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol
title_fullStr Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol
title_full_unstemmed Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol
title_short Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol
title_sort reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol
topic Histological and DTI Findings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743687/
https://www.ncbi.nlm.nih.gov/pubmed/31528388
http://dx.doi.org/10.25259/SNI-73-2019
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