New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease
Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of CVD in this population. Cardiovascular calcification results from complex cellular interactions involving the endoth...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784181/ https://www.ncbi.nlm.nih.gov/pubmed/31547340 http://dx.doi.org/10.3390/toxins11090529 |
_version_ | 1783457710351581184 |
---|---|
author | Hénaut, Lucie Candellier, Alexandre Boudot, Cédric Grissi, Maria Mentaverri, Romuald Choukroun, Gabriel Brazier, Michel Kamel, Saïd Massy, Ziad A. |
author_facet | Hénaut, Lucie Candellier, Alexandre Boudot, Cédric Grissi, Maria Mentaverri, Romuald Choukroun, Gabriel Brazier, Michel Kamel, Saïd Massy, Ziad A. |
author_sort | Hénaut, Lucie |
collection | PubMed |
description | Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of CVD in this population. Cardiovascular calcification results from complex cellular interactions involving the endothelium, vascular/valvular cells (i.e., vascular smooth muscle cells, valvular interstitial cells and resident fibroblasts), and monocyte-derived macrophages. Indeed, the production of pro-inflammatory cytokines and oxidative stress by monocyte-derived macrophages is responsible for the osteogenic transformation and mineralization of vascular/valvular cells. However, monocytes/macrophages show the ability to modify their phenotype, and consequently their functions, when facing environmental modifications. This plasticity complicates efforts to understand the pathogenesis of CVC—particularly in a CKD setting, where both uraemic toxins and CKD treatment may affect monocyte/macrophage functions and thereby influence CVC. Here, we review (i) the mechanisms by which each monocyte/macrophage subset either promotes or prevents CVC, and (ii) how both uraemic toxins and CKD therapies might affect these monocyte/macrophage functions. |
format | Online Article Text |
id | pubmed-6784181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67841812019-10-16 New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease Hénaut, Lucie Candellier, Alexandre Boudot, Cédric Grissi, Maria Mentaverri, Romuald Choukroun, Gabriel Brazier, Michel Kamel, Saïd Massy, Ziad A. Toxins (Basel) Review Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of CVD in this population. Cardiovascular calcification results from complex cellular interactions involving the endothelium, vascular/valvular cells (i.e., vascular smooth muscle cells, valvular interstitial cells and resident fibroblasts), and monocyte-derived macrophages. Indeed, the production of pro-inflammatory cytokines and oxidative stress by monocyte-derived macrophages is responsible for the osteogenic transformation and mineralization of vascular/valvular cells. However, monocytes/macrophages show the ability to modify their phenotype, and consequently their functions, when facing environmental modifications. This plasticity complicates efforts to understand the pathogenesis of CVC—particularly in a CKD setting, where both uraemic toxins and CKD treatment may affect monocyte/macrophage functions and thereby influence CVC. Here, we review (i) the mechanisms by which each monocyte/macrophage subset either promotes or prevents CVC, and (ii) how both uraemic toxins and CKD therapies might affect these monocyte/macrophage functions. MDPI 2019-09-12 /pmc/articles/PMC6784181/ /pubmed/31547340 http://dx.doi.org/10.3390/toxins11090529 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hénaut, Lucie Candellier, Alexandre Boudot, Cédric Grissi, Maria Mentaverri, Romuald Choukroun, Gabriel Brazier, Michel Kamel, Saïd Massy, Ziad A. New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease |
title | New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease |
title_full | New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease |
title_fullStr | New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease |
title_full_unstemmed | New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease |
title_short | New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease |
title_sort | new insights into the roles of monocytes/macrophages in cardiovascular calcification associated with chronic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784181/ https://www.ncbi.nlm.nih.gov/pubmed/31547340 http://dx.doi.org/10.3390/toxins11090529 |
work_keys_str_mv | AT henautlucie newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT candellieralexandre newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT boudotcedric newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT grissimaria newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT mentaverriromuald newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT choukroungabriel newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT braziermichel newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT kamelsaid newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease AT massyziada newinsightsintotherolesofmonocytesmacrophagesincardiovascularcalcificationassociatedwithchronickidneydisease |