New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease

Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of CVD in this population. Cardiovascular calcification results from complex cellular interactions involving the endoth...

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Autores principales: Hénaut, Lucie, Candellier, Alexandre, Boudot, Cédric, Grissi, Maria, Mentaverri, Romuald, Choukroun, Gabriel, Brazier, Michel, Kamel, Saïd, Massy, Ziad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784181/
https://www.ncbi.nlm.nih.gov/pubmed/31547340
http://dx.doi.org/10.3390/toxins11090529
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author Hénaut, Lucie
Candellier, Alexandre
Boudot, Cédric
Grissi, Maria
Mentaverri, Romuald
Choukroun, Gabriel
Brazier, Michel
Kamel, Saïd
Massy, Ziad A.
author_facet Hénaut, Lucie
Candellier, Alexandre
Boudot, Cédric
Grissi, Maria
Mentaverri, Romuald
Choukroun, Gabriel
Brazier, Michel
Kamel, Saïd
Massy, Ziad A.
author_sort Hénaut, Lucie
collection PubMed
description Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of CVD in this population. Cardiovascular calcification results from complex cellular interactions involving the endothelium, vascular/valvular cells (i.e., vascular smooth muscle cells, valvular interstitial cells and resident fibroblasts), and monocyte-derived macrophages. Indeed, the production of pro-inflammatory cytokines and oxidative stress by monocyte-derived macrophages is responsible for the osteogenic transformation and mineralization of vascular/valvular cells. However, monocytes/macrophages show the ability to modify their phenotype, and consequently their functions, when facing environmental modifications. This plasticity complicates efforts to understand the pathogenesis of CVC—particularly in a CKD setting, where both uraemic toxins and CKD treatment may affect monocyte/macrophage functions and thereby influence CVC. Here, we review (i) the mechanisms by which each monocyte/macrophage subset either promotes or prevents CVC, and (ii) how both uraemic toxins and CKD therapies might affect these monocyte/macrophage functions.
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spelling pubmed-67841812019-10-16 New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease Hénaut, Lucie Candellier, Alexandre Boudot, Cédric Grissi, Maria Mentaverri, Romuald Choukroun, Gabriel Brazier, Michel Kamel, Saïd Massy, Ziad A. Toxins (Basel) Review Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of CVD in this population. Cardiovascular calcification results from complex cellular interactions involving the endothelium, vascular/valvular cells (i.e., vascular smooth muscle cells, valvular interstitial cells and resident fibroblasts), and monocyte-derived macrophages. Indeed, the production of pro-inflammatory cytokines and oxidative stress by monocyte-derived macrophages is responsible for the osteogenic transformation and mineralization of vascular/valvular cells. However, monocytes/macrophages show the ability to modify their phenotype, and consequently their functions, when facing environmental modifications. This plasticity complicates efforts to understand the pathogenesis of CVC—particularly in a CKD setting, where both uraemic toxins and CKD treatment may affect monocyte/macrophage functions and thereby influence CVC. Here, we review (i) the mechanisms by which each monocyte/macrophage subset either promotes or prevents CVC, and (ii) how both uraemic toxins and CKD therapies might affect these monocyte/macrophage functions. MDPI 2019-09-12 /pmc/articles/PMC6784181/ /pubmed/31547340 http://dx.doi.org/10.3390/toxins11090529 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hénaut, Lucie
Candellier, Alexandre
Boudot, Cédric
Grissi, Maria
Mentaverri, Romuald
Choukroun, Gabriel
Brazier, Michel
Kamel, Saïd
Massy, Ziad A.
New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease
title New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease
title_full New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease
title_fullStr New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease
title_full_unstemmed New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease
title_short New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease
title_sort new insights into the roles of monocytes/macrophages in cardiovascular calcification associated with chronic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784181/
https://www.ncbi.nlm.nih.gov/pubmed/31547340
http://dx.doi.org/10.3390/toxins11090529
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