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Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

The risk of colorectal cancer (CRC) varies between people, and the cellular mechanisms mediating the differences in risk are largely unknown. Senescence has been implicated as a causative cellular mechanism for many diseases, including cancer, and may affect the risk for CRC. Senescent fibroblasts t...

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Detalles Bibliográficos
Autores principales: Guo, Yuna, Ayers, Jessica L., Carter, Kelly T., Wang, Ting, Maden, Sean K., Edmond, Darwin, Newcomb P, Polly, Li, Christopher, Ulrich, Cornelia, Yu, Ming, Grady, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826139/
https://www.ncbi.nlm.nih.gov/pubmed/31389184
http://dx.doi.org/10.1111/acel.13013