Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice

Transgenic mice that express either a NUP98–PHF23 (NP23) or NUP98-HOXD13 (NHD13) fusion in the hematopoietic compartment develop a wide spectrum of leukemias, including myeloid, erythroid, megakaryocytic and lymphoid, at age 9–14 months. NP23-NHD13 double transgenic mice were generated by interbreed...

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Detalles Bibliográficos
Autores principales: Kundu, Subhadip, Park, Eun Sil, Chung, Yang Jo, Walker, Robert L., Zhu, Yuelin J., Negi, Vijay, Meltzer, Paul S., Aplan, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868234/
https://www.ncbi.nlm.nih.gov/pubmed/31748606
http://dx.doi.org/10.1038/s41598-019-53610-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868234/
https://www.ncbi.nlm.nih.gov/pubmed/31748606
http://dx.doi.org/10.1038/s41598-019-53610-7

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