On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment

INTRODUCTION: Escherichia coli and Staphylococcus aureus are important causes of severe diseases like blood stream infections. This study comparatively assessed potential differences in their impact on disease severity in local and systemic infections. METHODS: Over a 5-year interval, patients in wh...

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Autores principales: Frickmann, Hagen, Hahn, Andreas, Berlec, Stefan, Ulrich, Johannes, Jansson, Moritz, Schwarz, Norbert Georg, Warnke, Philipp, Podbielski, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945993/
https://www.ncbi.nlm.nih.gov/pubmed/31934364
http://dx.doi.org/10.1556/1886.2019.00021
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author Frickmann, Hagen
Hahn, Andreas
Berlec, Stefan
Ulrich, Johannes
Jansson, Moritz
Schwarz, Norbert Georg
Warnke, Philipp
Podbielski, Andreas
author_facet Frickmann, Hagen
Hahn, Andreas
Berlec, Stefan
Ulrich, Johannes
Jansson, Moritz
Schwarz, Norbert Georg
Warnke, Philipp
Podbielski, Andreas
author_sort Frickmann, Hagen
collection PubMed
description INTRODUCTION: Escherichia coli and Staphylococcus aureus are important causes of severe diseases like blood stream infections. This study comparatively assessed potential differences in their impact on disease severity in local and systemic infections. METHODS: Over a 5-year interval, patients in whom either E. coli or S. aureus was detected in superficial or primary sterile compartments were assessed for the primary endpoint death during hospital stay and the secondary endpoints duration of hospital stay and infectious disease as the main diagnosis. RESULTS: Significance was achieved for the impacts as follows: Superficial infection with S. aureus was associated with an odds ratio of 0.27 regarding the risk of death and of 1.42 regarding infectious disease as main diagnosis. Superficial infection with E. coli was associated with a reduced duration of hospital stay by –2.46 days and a reduced odds ratio of infectious diseases as main diagnosis of 0.04. The hospital stay of patients with E. coli was increased due to third-generation cephalosporin and ciprofloxacin resistance, and in the case of patients with S. aureus due to tetracycline and fusidic acid resistance. CONCLUSIONS: Reduced disease severity of superficial infections due to both E. coli and S. aureus and resistance-driven prolonged stays in hospital were confirmed, while other outcome parameters were comparable.
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spelling pubmed-69459932020-01-13 On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment Frickmann, Hagen Hahn, Andreas Berlec, Stefan Ulrich, Johannes Jansson, Moritz Schwarz, Norbert Georg Warnke, Philipp Podbielski, Andreas Eur J Microbiol Immunol (Bp) Original Research Paper INTRODUCTION: Escherichia coli and Staphylococcus aureus are important causes of severe diseases like blood stream infections. This study comparatively assessed potential differences in their impact on disease severity in local and systemic infections. METHODS: Over a 5-year interval, patients in whom either E. coli or S. aureus was detected in superficial or primary sterile compartments were assessed for the primary endpoint death during hospital stay and the secondary endpoints duration of hospital stay and infectious disease as the main diagnosis. RESULTS: Significance was achieved for the impacts as follows: Superficial infection with S. aureus was associated with an odds ratio of 0.27 regarding the risk of death and of 1.42 regarding infectious disease as main diagnosis. Superficial infection with E. coli was associated with a reduced duration of hospital stay by –2.46 days and a reduced odds ratio of infectious diseases as main diagnosis of 0.04. The hospital stay of patients with E. coli was increased due to third-generation cephalosporin and ciprofloxacin resistance, and in the case of patients with S. aureus due to tetracycline and fusidic acid resistance. CONCLUSIONS: Reduced disease severity of superficial infections due to both E. coli and S. aureus and resistance-driven prolonged stays in hospital were confirmed, while other outcome parameters were comparable. Akadémiai Kiadó 2019-10-16 /pmc/articles/PMC6945993/ /pubmed/31934364 http://dx.doi.org/10.1556/1886.2019.00021 Text en © 2019, The Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes - if any – are indicated.
spellingShingle Original Research Paper
Frickmann, Hagen
Hahn, Andreas
Berlec, Stefan
Ulrich, Johannes
Jansson, Moritz
Schwarz, Norbert Georg
Warnke, Philipp
Podbielski, Andreas
On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment
title On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment
title_full On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment
title_fullStr On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment
title_full_unstemmed On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment
title_short On the Etiological Relevance of Escherichia coli and Staphylococcus aureus in Superficial and Deep Infections – A Hypothesis-Forming, Retrospective Assessment
title_sort on the etiological relevance of escherichia coli and staphylococcus aureus in superficial and deep infections – a hypothesis-forming, retrospective assessment
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945993/
https://www.ncbi.nlm.nih.gov/pubmed/31934364
http://dx.doi.org/10.1556/1886.2019.00021
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