Cargando…
Antitumor Features of Vegetal Protein-Based Nanotherapeutics
The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023308/ https://www.ncbi.nlm.nih.gov/pubmed/31952147 http://dx.doi.org/10.3390/pharmaceutics12010065 |
_version_ | 1783498219328634880 |
---|---|
author | Voci, Silvia Gagliardi, Agnese Fresta, Massimo Cosco, Donato |
author_facet | Voci, Silvia Gagliardi, Agnese Fresta, Massimo Cosco, Donato |
author_sort | Voci, Silvia |
collection | PubMed |
description | The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of plant-derived proteins as innovative, safe and renewable raw materials to be used for the development of polymeric nanoparticles unlocked a new scenario in the drug delivery field. In particular, the reduced size of the colloidal systems combined with the peculiar properties of non-immunogenic polymers favored the characterization and evaluation of the pharmacological activity of the novel nanoformulations. The aim of this review is to describe the physico-chemical properties of nanoparticles composed of vegetal proteins used to retain and deliver anticancer drugs, together with the most important preparation methods and the pharmacological features of these potential nanomedicines. |
format | Online Article Text |
id | pubmed-7023308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70233082020-03-12 Antitumor Features of Vegetal Protein-Based Nanotherapeutics Voci, Silvia Gagliardi, Agnese Fresta, Massimo Cosco, Donato Pharmaceutics Review The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of plant-derived proteins as innovative, safe and renewable raw materials to be used for the development of polymeric nanoparticles unlocked a new scenario in the drug delivery field. In particular, the reduced size of the colloidal systems combined with the peculiar properties of non-immunogenic polymers favored the characterization and evaluation of the pharmacological activity of the novel nanoformulations. The aim of this review is to describe the physico-chemical properties of nanoparticles composed of vegetal proteins used to retain and deliver anticancer drugs, together with the most important preparation methods and the pharmacological features of these potential nanomedicines. MDPI 2020-01-15 /pmc/articles/PMC7023308/ /pubmed/31952147 http://dx.doi.org/10.3390/pharmaceutics12010065 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Voci, Silvia Gagliardi, Agnese Fresta, Massimo Cosco, Donato Antitumor Features of Vegetal Protein-Based Nanotherapeutics |
title | Antitumor Features of Vegetal Protein-Based Nanotherapeutics |
title_full | Antitumor Features of Vegetal Protein-Based Nanotherapeutics |
title_fullStr | Antitumor Features of Vegetal Protein-Based Nanotherapeutics |
title_full_unstemmed | Antitumor Features of Vegetal Protein-Based Nanotherapeutics |
title_short | Antitumor Features of Vegetal Protein-Based Nanotherapeutics |
title_sort | antitumor features of vegetal protein-based nanotherapeutics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023308/ https://www.ncbi.nlm.nih.gov/pubmed/31952147 http://dx.doi.org/10.3390/pharmaceutics12010065 |
work_keys_str_mv | AT vocisilvia antitumorfeaturesofvegetalproteinbasednanotherapeutics AT gagliardiagnese antitumorfeaturesofvegetalproteinbasednanotherapeutics AT frestamassimo antitumorfeaturesofvegetalproteinbasednanotherapeutics AT coscodonato antitumorfeaturesofvegetalproteinbasednanotherapeutics |