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Antitumor Features of Vegetal Protein-Based Nanotherapeutics

The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of...

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Detalles Bibliográficos
Autores principales: Voci, Silvia, Gagliardi, Agnese, Fresta, Massimo, Cosco, Donato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023308/
https://www.ncbi.nlm.nih.gov/pubmed/31952147
http://dx.doi.org/10.3390/pharmaceutics12010065
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author Voci, Silvia
Gagliardi, Agnese
Fresta, Massimo
Cosco, Donato
author_facet Voci, Silvia
Gagliardi, Agnese
Fresta, Massimo
Cosco, Donato
author_sort Voci, Silvia
collection PubMed
description The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of plant-derived proteins as innovative, safe and renewable raw materials to be used for the development of polymeric nanoparticles unlocked a new scenario in the drug delivery field. In particular, the reduced size of the colloidal systems combined with the peculiar properties of non-immunogenic polymers favored the characterization and evaluation of the pharmacological activity of the novel nanoformulations. The aim of this review is to describe the physico-chemical properties of nanoparticles composed of vegetal proteins used to retain and deliver anticancer drugs, together with the most important preparation methods and the pharmacological features of these potential nanomedicines.
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spelling pubmed-70233082020-03-12 Antitumor Features of Vegetal Protein-Based Nanotherapeutics Voci, Silvia Gagliardi, Agnese Fresta, Massimo Cosco, Donato Pharmaceutics Review The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of plant-derived proteins as innovative, safe and renewable raw materials to be used for the development of polymeric nanoparticles unlocked a new scenario in the drug delivery field. In particular, the reduced size of the colloidal systems combined with the peculiar properties of non-immunogenic polymers favored the characterization and evaluation of the pharmacological activity of the novel nanoformulations. The aim of this review is to describe the physico-chemical properties of nanoparticles composed of vegetal proteins used to retain and deliver anticancer drugs, together with the most important preparation methods and the pharmacological features of these potential nanomedicines. MDPI 2020-01-15 /pmc/articles/PMC7023308/ /pubmed/31952147 http://dx.doi.org/10.3390/pharmaceutics12010065 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Voci, Silvia
Gagliardi, Agnese
Fresta, Massimo
Cosco, Donato
Antitumor Features of Vegetal Protein-Based Nanotherapeutics
title Antitumor Features of Vegetal Protein-Based Nanotherapeutics
title_full Antitumor Features of Vegetal Protein-Based Nanotherapeutics
title_fullStr Antitumor Features of Vegetal Protein-Based Nanotherapeutics
title_full_unstemmed Antitumor Features of Vegetal Protein-Based Nanotherapeutics
title_short Antitumor Features of Vegetal Protein-Based Nanotherapeutics
title_sort antitumor features of vegetal protein-based nanotherapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023308/
https://www.ncbi.nlm.nih.gov/pubmed/31952147
http://dx.doi.org/10.3390/pharmaceutics12010065
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