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From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases

Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant metabolites with therapeutic effects. Besides Δ9-tetrahydrocannabinol that is the principal psychoactive constituent of Cannabis, cannabidiol (CBD) is the most abundant nonpsychoactive phytocannabinoid and may represent...

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Autores principales: Cassano, Tommaso, Villani, Rosanna, Pace, Lorenzo, Carbone, Antonio, Bukke, Vidyasagar Naik, Orkisz, Stanislaw, Avolio, Carlo, Serviddio, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069528/
https://www.ncbi.nlm.nih.gov/pubmed/32210795
http://dx.doi.org/10.3389/fphar.2020.00124
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author Cassano, Tommaso
Villani, Rosanna
Pace, Lorenzo
Carbone, Antonio
Bukke, Vidyasagar Naik
Orkisz, Stanislaw
Avolio, Carlo
Serviddio, Gaetano
author_facet Cassano, Tommaso
Villani, Rosanna
Pace, Lorenzo
Carbone, Antonio
Bukke, Vidyasagar Naik
Orkisz, Stanislaw
Avolio, Carlo
Serviddio, Gaetano
author_sort Cassano, Tommaso
collection PubMed
description Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant metabolites with therapeutic effects. Besides Δ9-tetrahydrocannabinol that is the principal psychoactive constituent of Cannabis, cannabidiol (CBD) is the most abundant nonpsychoactive phytocannabinoid and may represent a prototype for anti-inflammatory drug development for human pathologies where both the inflammation and oxidative stress (OS) play an important role to their etiology and progression. To this regard, Alzheimer's disease (AD), Parkinson's disease (PD), the most common neurodegenerative disorders, are characterized by extensive oxidative damage to different biological substrates that can cause cell death by different pathways. Most cases of neurodegenerative diseases have a complex etiology with a variety of factors contributing to the progression of the neurodegenerative processes; therefore, promising treatment strategies should simultaneously target multiple substrates in order to stop and/or slow down the neurodegeneration. In this context, CBD, which interacts with the eCB system, but has also cannabinoid receptor-independent mechanism, might be a good candidate as a prototype for anti-oxidant drug development for the major neurodegenerative disorders, such as PD and AD. This review summarizes the multiple molecular pathways that underlie the positive effects of CBD, which may have a considerable impact on the progression of the major neurodegenerative disorders.
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spelling pubmed-70695282020-03-24 From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases Cassano, Tommaso Villani, Rosanna Pace, Lorenzo Carbone, Antonio Bukke, Vidyasagar Naik Orkisz, Stanislaw Avolio, Carlo Serviddio, Gaetano Front Pharmacol Pharmacology Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant metabolites with therapeutic effects. Besides Δ9-tetrahydrocannabinol that is the principal psychoactive constituent of Cannabis, cannabidiol (CBD) is the most abundant nonpsychoactive phytocannabinoid and may represent a prototype for anti-inflammatory drug development for human pathologies where both the inflammation and oxidative stress (OS) play an important role to their etiology and progression. To this regard, Alzheimer's disease (AD), Parkinson's disease (PD), the most common neurodegenerative disorders, are characterized by extensive oxidative damage to different biological substrates that can cause cell death by different pathways. Most cases of neurodegenerative diseases have a complex etiology with a variety of factors contributing to the progression of the neurodegenerative processes; therefore, promising treatment strategies should simultaneously target multiple substrates in order to stop and/or slow down the neurodegeneration. In this context, CBD, which interacts with the eCB system, but has also cannabinoid receptor-independent mechanism, might be a good candidate as a prototype for anti-oxidant drug development for the major neurodegenerative disorders, such as PD and AD. This review summarizes the multiple molecular pathways that underlie the positive effects of CBD, which may have a considerable impact on the progression of the major neurodegenerative disorders. Frontiers Media S.A. 2020-03-06 /pmc/articles/PMC7069528/ /pubmed/32210795 http://dx.doi.org/10.3389/fphar.2020.00124 Text en Copyright © 2020 Cassano, Villani, Pace, Carbone, Bukke, Orkisz, Avolio and Serviddio http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Cassano, Tommaso
Villani, Rosanna
Pace, Lorenzo
Carbone, Antonio
Bukke, Vidyasagar Naik
Orkisz, Stanislaw
Avolio, Carlo
Serviddio, Gaetano
From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
title From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
title_full From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
title_fullStr From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
title_full_unstemmed From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
title_short From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
title_sort from cannabis sativa to cannabidiol: promising therapeutic candidate for the treatment of neurodegenerative diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069528/
https://www.ncbi.nlm.nih.gov/pubmed/32210795
http://dx.doi.org/10.3389/fphar.2020.00124
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