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CEA adhesion molecules: multifunctional proteins with signal-regulatory properties
The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell—cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory protein...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Published by Elsevier Ltd.
1997
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135799/ https://www.ncbi.nlm.nih.gov/pubmed/9330864 http://dx.doi.org/10.1016/S0955-0674(97)80114-7 |
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author | Öbrink, Björn |
author_facet | Öbrink, Björn |
author_sort | Öbrink, Björn |
collection | PubMed |
description | The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell—cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions. |
format | Online Article Text |
id | pubmed-7135799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71357992020-04-08 CEA adhesion molecules: multifunctional proteins with signal-regulatory properties Öbrink, Björn Curr Opin Cell Biol Article The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell—cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions. Published by Elsevier Ltd. 1997-10 2002-02-25 /pmc/articles/PMC7135799/ /pubmed/9330864 http://dx.doi.org/10.1016/S0955-0674(97)80114-7 Text en Copyright © 1997 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Öbrink, Björn CEA adhesion molecules: multifunctional proteins with signal-regulatory properties |
title | CEA adhesion molecules: multifunctional proteins with signal-regulatory properties |
title_full | CEA adhesion molecules: multifunctional proteins with signal-regulatory properties |
title_fullStr | CEA adhesion molecules: multifunctional proteins with signal-regulatory properties |
title_full_unstemmed | CEA adhesion molecules: multifunctional proteins with signal-regulatory properties |
title_short | CEA adhesion molecules: multifunctional proteins with signal-regulatory properties |
title_sort | cea adhesion molecules: multifunctional proteins with signal-regulatory properties |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135799/ https://www.ncbi.nlm.nih.gov/pubmed/9330864 http://dx.doi.org/10.1016/S0955-0674(97)80114-7 |
work_keys_str_mv | AT obrinkbjorn ceaadhesionmoleculesmultifunctionalproteinswithsignalregulatoryproperties |