Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs
Genome-wide RNA sequencing has shown that only a small fraction of the human genome is transcribed into protein-coding mRNAs. While once thought to be “junk” DNA, recent findings indicate that the rest of the genome encodes many types of non-coding RNA molecules with a myriad of functions still bein...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279485/ https://www.ncbi.nlm.nih.gov/pubmed/32466143 http://dx.doi.org/10.3390/ijms21103711 |
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author | Sedano, Melina J. Harrison, Alana L. Zilaie, Mina Das, Chandrima Choudhari, Ramesh Ramos, Enrique Gadad, Shrikanth S. |
author_facet | Sedano, Melina J. Harrison, Alana L. Zilaie, Mina Das, Chandrima Choudhari, Ramesh Ramos, Enrique Gadad, Shrikanth S. |
author_sort | Sedano, Melina J. |
collection | PubMed |
description | Genome-wide RNA sequencing has shown that only a small fraction of the human genome is transcribed into protein-coding mRNAs. While once thought to be “junk” DNA, recent findings indicate that the rest of the genome encodes many types of non-coding RNA molecules with a myriad of functions still being determined. Among the non-coding RNAs, long non-coding RNAs (lncRNA) and enhancer RNAs (eRNA) are found to be most copious. While their exact biological functions and mechanisms of action are currently unknown, technologies such as next-generation RNA sequencing (RNA-seq) and global nuclear run-on sequencing (GRO-seq) have begun deciphering their expression patterns and biological significance. In addition to their identification, it has been shown that the expression of long non-coding RNAs and enhancer RNAs can vary due to spatial, temporal, developmental, or hormonal variations. In this review, we explore newly reported information on estrogen-regulated eRNAs and lncRNAs and their associated biological functions to help outline their markedly prominent roles in estrogen-dependent signaling. |
format | Online Article Text |
id | pubmed-7279485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72794852020-06-17 Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs Sedano, Melina J. Harrison, Alana L. Zilaie, Mina Das, Chandrima Choudhari, Ramesh Ramos, Enrique Gadad, Shrikanth S. Int J Mol Sci Review Genome-wide RNA sequencing has shown that only a small fraction of the human genome is transcribed into protein-coding mRNAs. While once thought to be “junk” DNA, recent findings indicate that the rest of the genome encodes many types of non-coding RNA molecules with a myriad of functions still being determined. Among the non-coding RNAs, long non-coding RNAs (lncRNA) and enhancer RNAs (eRNA) are found to be most copious. While their exact biological functions and mechanisms of action are currently unknown, technologies such as next-generation RNA sequencing (RNA-seq) and global nuclear run-on sequencing (GRO-seq) have begun deciphering their expression patterns and biological significance. In addition to their identification, it has been shown that the expression of long non-coding RNAs and enhancer RNAs can vary due to spatial, temporal, developmental, or hormonal variations. In this review, we explore newly reported information on estrogen-regulated eRNAs and lncRNAs and their associated biological functions to help outline their markedly prominent roles in estrogen-dependent signaling. MDPI 2020-05-25 /pmc/articles/PMC7279485/ /pubmed/32466143 http://dx.doi.org/10.3390/ijms21103711 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sedano, Melina J. Harrison, Alana L. Zilaie, Mina Das, Chandrima Choudhari, Ramesh Ramos, Enrique Gadad, Shrikanth S. Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs |
title | Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs |
title_full | Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs |
title_fullStr | Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs |
title_full_unstemmed | Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs |
title_short | Emerging Roles of Estrogen-Regulated Enhancer and Long Non-Coding RNAs |
title_sort | emerging roles of estrogen-regulated enhancer and long non-coding rnas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279485/ https://www.ncbi.nlm.nih.gov/pubmed/32466143 http://dx.doi.org/10.3390/ijms21103711 |
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