Pyrazolo[4,3-c]pyridine-4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway Downregulation

BACKGROUND: Post-traumatic epilepsy (PTE) is a common type of acquired epilepsies secondary to traumatic brain injury (TBI), accounting for approximately 10–25% of patients. The present study evaluated activity of PP-4-one against mTOR signaling activation in a rat model of FeCl(2)-induced post-trau...

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Detalles Bibliográficos
Autores principales: Jin, Jungong, Shen, Xi, Tian, Lu, He, Guoyishi, Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392056/
https://www.ncbi.nlm.nih.gov/pubmed/32687486
http://dx.doi.org/10.12659/MSM.923919