Monocyte activation in systemic Covid-19 infection: Assay and rationale

Mononuclear phagocytes are a widely distributed family of cells contributing to innate and adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages of SARS COVID-19. They contribute to comorbidities predisposing to clinical infection, virus resistance and disseminati...

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Autores principales: Martinez, Fernando O., Combes, Theo W., Orsenigo, Federica, Gordon, Siamon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456455/
https://www.ncbi.nlm.nih.gov/pubmed/32861199
http://dx.doi.org/10.1016/j.ebiom.2020.102964
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author Martinez, Fernando O.
Combes, Theo W.
Orsenigo, Federica
Gordon, Siamon
author_facet Martinez, Fernando O.
Combes, Theo W.
Orsenigo, Federica
Gordon, Siamon
author_sort Martinez, Fernando O.
collection PubMed
description Mononuclear phagocytes are a widely distributed family of cells contributing to innate and adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages of SARS COVID-19. They contribute to comorbidities predisposing to clinical infection, virus resistance and dissemination, and to host factors that determine disease severity, recovery and sequelae. Assays are available to detect viral infection and antibody responses, but no adequate tests have been developed to measure the activation level of monocytes and tissue macrophages, and the risk of progression to a fatal hyperinflammatory syndrome. Blood monocytes provide a window on the systemic immune response, from production to tissue recruitment, reflecting the impact of infection on the host. Ready availability of blood makes it possible to monitor severity and the risk of potentially lethal complications, by developing tests to assess the status of monocyte activation and its potential for further inflammatory dysregulation after recruitment to tissues and during recovery.
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spelling pubmed-74564552020-08-31 Monocyte activation in systemic Covid-19 infection: Assay and rationale Martinez, Fernando O. Combes, Theo W. Orsenigo, Federica Gordon, Siamon EBioMedicine Review Mononuclear phagocytes are a widely distributed family of cells contributing to innate and adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages of SARS COVID-19. They contribute to comorbidities predisposing to clinical infection, virus resistance and dissemination, and to host factors that determine disease severity, recovery and sequelae. Assays are available to detect viral infection and antibody responses, but no adequate tests have been developed to measure the activation level of monocytes and tissue macrophages, and the risk of progression to a fatal hyperinflammatory syndrome. Blood monocytes provide a window on the systemic immune response, from production to tissue recruitment, reflecting the impact of infection on the host. Ready availability of blood makes it possible to monitor severity and the risk of potentially lethal complications, by developing tests to assess the status of monocyte activation and its potential for further inflammatory dysregulation after recruitment to tissues and during recovery. Elsevier 2020-08-30 /pmc/articles/PMC7456455/ /pubmed/32861199 http://dx.doi.org/10.1016/j.ebiom.2020.102964 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Martinez, Fernando O.
Combes, Theo W.
Orsenigo, Federica
Gordon, Siamon
Monocyte activation in systemic Covid-19 infection: Assay and rationale
title Monocyte activation in systemic Covid-19 infection: Assay and rationale
title_full Monocyte activation in systemic Covid-19 infection: Assay and rationale
title_fullStr Monocyte activation in systemic Covid-19 infection: Assay and rationale
title_full_unstemmed Monocyte activation in systemic Covid-19 infection: Assay and rationale
title_short Monocyte activation in systemic Covid-19 infection: Assay and rationale
title_sort monocyte activation in systemic covid-19 infection: assay and rationale
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456455/
https://www.ncbi.nlm.nih.gov/pubmed/32861199
http://dx.doi.org/10.1016/j.ebiom.2020.102964
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