Limitations of Ribotyping as Genotyping Method for Corynebacterium ulcerans

We conducted molecular typing of a Corynebacterium ulcerans isolate from a woman who died in Japan in 2016. Genomic DNA modification might have affected the isolate’s ribotyping profile. Multilocus sequence typing results (sequence type 337) were more accurate. Whole-genome sequencing had greater ab...

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Detalles Bibliográficos
Autores principales: Sekizuka, Tsuyoshi, Katsukawa, Chihiro, Kuroda, Makoto, Shibayama, Keigo, Otsuji, Ken, Saito, Mitsumasa, Yamamoto, Akihiko, Iwaki, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510715/
https://www.ncbi.nlm.nih.gov/pubmed/32946740
http://dx.doi.org/10.3201/eid2610.200086
Descripción
Sumario:We conducted molecular typing of a Corynebacterium ulcerans isolate from a woman who died in Japan in 2016. Genomic DNA modification might have affected the isolate’s ribotyping profile. Multilocus sequence typing results (sequence type 337) were more accurate. Whole-genome sequencing had greater ability to discriminate lineages at high resolution.

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