Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis

OBJECTIVE: This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein–protein interaction network. RESULTS: We used target proteins to create protein–protein interaction network (PPIN) and identified significant node and edg...

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Autores principales: Kumari, Sangeeta, Subramanya, Hosahalli S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541209/
https://www.ncbi.nlm.nih.gov/pubmed/33028406
http://dx.doi.org/10.1186/s13104-020-05301-0
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author Kumari, Sangeeta
Subramanya, Hosahalli S.
author_facet Kumari, Sangeeta
Subramanya, Hosahalli S.
author_sort Kumari, Sangeeta
collection PubMed
description OBJECTIVE: This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein–protein interaction network. RESULTS: We used target proteins to create protein–protein interaction network (PPIN) and identified significant node and edge attributes of PPIN. We identified the cluster of proteins in the PPIN, which were used to identify enriched pathways. We identified closeness centrality and jaccard score as most important node and edge attribute of the PPIN respectively. The enriched pathways of various clusters were overlapped suggesting synergistic mechanism of action. The three pathways found to be common among three clusters were Gonadotropin-releasing hormone receptor pathway, Endothelin signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway.
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spelling pubmed-75412092020-10-08 Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis Kumari, Sangeeta Subramanya, Hosahalli S. BMC Res Notes Research Note OBJECTIVE: This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein–protein interaction network. RESULTS: We used target proteins to create protein–protein interaction network (PPIN) and identified significant node and edge attributes of PPIN. We identified the cluster of proteins in the PPIN, which were used to identify enriched pathways. We identified closeness centrality and jaccard score as most important node and edge attribute of the PPIN respectively. The enriched pathways of various clusters were overlapped suggesting synergistic mechanism of action. The three pathways found to be common among three clusters were Gonadotropin-releasing hormone receptor pathway, Endothelin signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway. BioMed Central 2020-10-07 /pmc/articles/PMC7541209/ /pubmed/33028406 http://dx.doi.org/10.1186/s13104-020-05301-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Kumari, Sangeeta
Subramanya, Hosahalli S.
Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis
title Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis
title_full Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis
title_fullStr Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis
title_full_unstemmed Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis
title_short Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis
title_sort network pharmacology study of curcuma longa l.: potential target proteins and their functional enrichment analysis
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541209/
https://www.ncbi.nlm.nih.gov/pubmed/33028406
http://dx.doi.org/10.1186/s13104-020-05301-0
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