Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown promise in allograft rejection and autoimmune...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565705/ https://www.ncbi.nlm.nih.gov/pubmed/32917054 http://dx.doi.org/10.3390/cells9092063 |
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author | Raker, Verena K. Becker, Christian Landfester, Katharina Steinbrink, Kerstin |
author_facet | Raker, Verena K. Becker, Christian Landfester, Katharina Steinbrink, Kerstin |
author_sort | Raker, Verena K. |
collection | PubMed |
description | Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown promise in allograft rejection and autoimmune and inflammatory diseases. However, its pleiotropic nature and the existence of IL-2 receptors with different binding affinity limit its therapeutic application. For an improved clinical applicability of the cytokine, a targeted receptor assignment must, therefore, be achieved. Nanoparticles allow controlling the location and dose of immunomodulating compounds and to specifically address specific receptors through targeted drug binding. In this review article we discuss the IL-2 biology and current clinical application with regard to nanoparticle-based IL-2-mediated manipulation of T cell responses in autoimmunity, chronic inflammation, and cancer. |
format | Online Article Text |
id | pubmed-7565705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75657052020-10-26 Targeted Activation of T Cells with IL-2-Coupled Nanoparticles Raker, Verena K. Becker, Christian Landfester, Katharina Steinbrink, Kerstin Cells Review Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown promise in allograft rejection and autoimmune and inflammatory diseases. However, its pleiotropic nature and the existence of IL-2 receptors with different binding affinity limit its therapeutic application. For an improved clinical applicability of the cytokine, a targeted receptor assignment must, therefore, be achieved. Nanoparticles allow controlling the location and dose of immunomodulating compounds and to specifically address specific receptors through targeted drug binding. In this review article we discuss the IL-2 biology and current clinical application with regard to nanoparticle-based IL-2-mediated manipulation of T cell responses in autoimmunity, chronic inflammation, and cancer. MDPI 2020-09-09 /pmc/articles/PMC7565705/ /pubmed/32917054 http://dx.doi.org/10.3390/cells9092063 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Raker, Verena K. Becker, Christian Landfester, Katharina Steinbrink, Kerstin Targeted Activation of T Cells with IL-2-Coupled Nanoparticles |
title | Targeted Activation of T Cells with IL-2-Coupled Nanoparticles |
title_full | Targeted Activation of T Cells with IL-2-Coupled Nanoparticles |
title_fullStr | Targeted Activation of T Cells with IL-2-Coupled Nanoparticles |
title_full_unstemmed | Targeted Activation of T Cells with IL-2-Coupled Nanoparticles |
title_short | Targeted Activation of T Cells with IL-2-Coupled Nanoparticles |
title_sort | targeted activation of t cells with il-2-coupled nanoparticles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565705/ https://www.ncbi.nlm.nih.gov/pubmed/32917054 http://dx.doi.org/10.3390/cells9092063 |
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