Targeted Activation of T Cells with IL-2-Coupled Nanoparticles

Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown promise in allograft rejection and autoimmune...

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Autores principales: Raker, Verena K., Becker, Christian, Landfester, Katharina, Steinbrink, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565705/
https://www.ncbi.nlm.nih.gov/pubmed/32917054
http://dx.doi.org/10.3390/cells9092063
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author Raker, Verena K.
Becker, Christian
Landfester, Katharina
Steinbrink, Kerstin
author_facet Raker, Verena K.
Becker, Christian
Landfester, Katharina
Steinbrink, Kerstin
author_sort Raker, Verena K.
collection PubMed
description Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown promise in allograft rejection and autoimmune and inflammatory diseases. However, its pleiotropic nature and the existence of IL-2 receptors with different binding affinity limit its therapeutic application. For an improved clinical applicability of the cytokine, a targeted receptor assignment must, therefore, be achieved. Nanoparticles allow controlling the location and dose of immunomodulating compounds and to specifically address specific receptors through targeted drug binding. In this review article we discuss the IL-2 biology and current clinical application with regard to nanoparticle-based IL-2-mediated manipulation of T cell responses in autoimmunity, chronic inflammation, and cancer.
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spelling pubmed-75657052020-10-26 Targeted Activation of T Cells with IL-2-Coupled Nanoparticles Raker, Verena K. Becker, Christian Landfester, Katharina Steinbrink, Kerstin Cells Review Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown promise in allograft rejection and autoimmune and inflammatory diseases. However, its pleiotropic nature and the existence of IL-2 receptors with different binding affinity limit its therapeutic application. For an improved clinical applicability of the cytokine, a targeted receptor assignment must, therefore, be achieved. Nanoparticles allow controlling the location and dose of immunomodulating compounds and to specifically address specific receptors through targeted drug binding. In this review article we discuss the IL-2 biology and current clinical application with regard to nanoparticle-based IL-2-mediated manipulation of T cell responses in autoimmunity, chronic inflammation, and cancer. MDPI 2020-09-09 /pmc/articles/PMC7565705/ /pubmed/32917054 http://dx.doi.org/10.3390/cells9092063 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Raker, Verena K.
Becker, Christian
Landfester, Katharina
Steinbrink, Kerstin
Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
title Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
title_full Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
title_fullStr Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
title_full_unstemmed Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
title_short Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
title_sort targeted activation of t cells with il-2-coupled nanoparticles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565705/
https://www.ncbi.nlm.nih.gov/pubmed/32917054
http://dx.doi.org/10.3390/cells9092063
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