Synthesis and initial screening of lactate dehydrogenase inhibitor activity of 1,3-benzodioxole derivatives
Cancer is one of the main causes of mortality in the world. Many cancer cells produce ATP through high-level lactic acid fermentation catalyzed by lactate dehydrogenase (LDH), which converts pyruvic acid to lactic acid. LDH plays a dominant role in the Warburg effect, wherein aerobic glycolysis is f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669867/ https://www.ncbi.nlm.nih.gov/pubmed/33199724 http://dx.doi.org/10.1038/s41598-020-77056-4 |