Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review

BACKGROUND: An anaplastic large cell lymphoma (ALCL) involving the cervical spine and leading to quadriplegia is very rare. CASE DESCRIPTION: A 48-year-old immunocompetent male presented with quadriplegia that warranted an anterior cervical corpectomy/fusion. He was previously being presumptively tr...

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Autores principales: Basu, Garga, Anthony, Michael L., Bakliwal, Anamika, Chattopadhyay, Debranjani, Joshi, Prashant P., Arora, Rajnish Kumar, Mittal, Radhey Shyam, Nath, Uttam Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771492/
https://www.ncbi.nlm.nih.gov/pubmed/33408907
http://dx.doi.org/10.25259/SNI_634_2020
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author Basu, Garga
Anthony, Michael L.
Bakliwal, Anamika
Chattopadhyay, Debranjani
Joshi, Prashant P.
Arora, Rajnish Kumar
Mittal, Radhey Shyam
Nath, Uttam Kumar
author_facet Basu, Garga
Anthony, Michael L.
Bakliwal, Anamika
Chattopadhyay, Debranjani
Joshi, Prashant P.
Arora, Rajnish Kumar
Mittal, Radhey Shyam
Nath, Uttam Kumar
author_sort Basu, Garga
collection PubMed
description BACKGROUND: An anaplastic large cell lymphoma (ALCL) involving the cervical spine and leading to quadriplegia is very rare. CASE DESCRIPTION: A 48-year-old immunocompetent male presented with quadriplegia that warranted an anterior cervical corpectomy/fusion. He was previously being presumptively treated for cervical disease attributed to tuberculosis. The histopathology and immunohistochemistry revealed an ALCL that was anaplastic lymphoma kinase (ALK) negative. The patient had a favorable response to surgery followed by CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisolone) chemotherapy. CONCLUSION: ALK-negative ALCL presenting with quadriplegia due to primary involvement of cervical spine is extremely rare, but must be diagnosed and appropriately managed.
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spelling pubmed-77714922021-01-05 Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review Basu, Garga Anthony, Michael L. Bakliwal, Anamika Chattopadhyay, Debranjani Joshi, Prashant P. Arora, Rajnish Kumar Mittal, Radhey Shyam Nath, Uttam Kumar Surg Neurol Int Case Report BACKGROUND: An anaplastic large cell lymphoma (ALCL) involving the cervical spine and leading to quadriplegia is very rare. CASE DESCRIPTION: A 48-year-old immunocompetent male presented with quadriplegia that warranted an anterior cervical corpectomy/fusion. He was previously being presumptively treated for cervical disease attributed to tuberculosis. The histopathology and immunohistochemistry revealed an ALCL that was anaplastic lymphoma kinase (ALK) negative. The patient had a favorable response to surgery followed by CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisolone) chemotherapy. CONCLUSION: ALK-negative ALCL presenting with quadriplegia due to primary involvement of cervical spine is extremely rare, but must be diagnosed and appropriately managed. Scientific Scholar 2020-11-06 /pmc/articles/PMC7771492/ /pubmed/33408907 http://dx.doi.org/10.25259/SNI_634_2020 Text en Copyright: © 2020 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Basu, Garga
Anthony, Michael L.
Bakliwal, Anamika
Chattopadhyay, Debranjani
Joshi, Prashant P.
Arora, Rajnish Kumar
Mittal, Radhey Shyam
Nath, Uttam Kumar
Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review
title Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review
title_full Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review
title_fullStr Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review
title_full_unstemmed Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review
title_short Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review
title_sort primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771492/
https://www.ncbi.nlm.nih.gov/pubmed/33408907
http://dx.doi.org/10.25259/SNI_634_2020
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