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Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1
Ring finger protein 2 (RNF2) is an important component of polycomb repressive complex 1. RNF2 is upregulated in many kinds of tumors, and elevated RNF2 expression is associated with a poor prognosis in certain cancers. To assess the function of RNF2 in colorectal cancer, we examined RNF2 protein lev...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803491/ https://www.ncbi.nlm.nih.gov/pubmed/33346749 http://dx.doi.org/10.18632/aging.202396 |
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author | Wei, Feilong Jing, Haoren Wei, Ming Liu, Lei Wu, Jieheng Wang, Meng Han, Donghui Yang, Fa Yang, Bo Jiao, Dian Zheng, Guoxu Zhang, Lingling Xi, Wenjin Guo, Zhangyan Yang, An-Gang Qin, Weijun Zhou, Yi Wen, Weihong |
author_facet | Wei, Feilong Jing, Haoren Wei, Ming Liu, Lei Wu, Jieheng Wang, Meng Han, Donghui Yang, Fa Yang, Bo Jiao, Dian Zheng, Guoxu Zhang, Lingling Xi, Wenjin Guo, Zhangyan Yang, An-Gang Qin, Weijun Zhou, Yi Wen, Weihong |
author_sort | Wei, Feilong |
collection | PubMed |
description | Ring finger protein 2 (RNF2) is an important component of polycomb repressive complex 1. RNF2 is upregulated in many kinds of tumors, and elevated RNF2 expression is associated with a poor prognosis in certain cancers. To assess the function of RNF2 in colorectal cancer, we examined RNF2 protein levels in 313 paired colorectal cancer tissues and adjacent normal tissues. We then analyzed the association of RNF2 expression with the patients’ clinicopathologic features and prognoses. RNF2 expression was upregulated in colorectal cancer tissues and was associated with the tumor differentiation status, tumor stage and prognosis. In colorectal cancer cell lines, downregulation of RNF2 inhibited cell proliferation and induced apoptosis. Gene microarray analysis revealed that early growth response 1 (EGR1) was upregulated in RNF2-knockdown cells. Knocking down EGR1 partially reversed the inhibition of cell proliferation and the induction of apoptosis in RNF2-knockdown cells. RNF2 was enriched at the EGR1 promoter, where it mono-ubiquitinated histone H2A, thereby inhibiting EGR1 expression. These results indicate that RNF2 is oncogenic in colorectal cancer and may promote disease progression by inhibiting EGR1 expression. RNF2 is thus a potential prognostic marker and therapeutic target in colorectal cancer. |
format | Online Article Text |
id | pubmed-7803491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-78034912021-01-15 Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 Wei, Feilong Jing, Haoren Wei, Ming Liu, Lei Wu, Jieheng Wang, Meng Han, Donghui Yang, Fa Yang, Bo Jiao, Dian Zheng, Guoxu Zhang, Lingling Xi, Wenjin Guo, Zhangyan Yang, An-Gang Qin, Weijun Zhou, Yi Wen, Weihong Aging (Albany NY) Research Paper Ring finger protein 2 (RNF2) is an important component of polycomb repressive complex 1. RNF2 is upregulated in many kinds of tumors, and elevated RNF2 expression is associated with a poor prognosis in certain cancers. To assess the function of RNF2 in colorectal cancer, we examined RNF2 protein levels in 313 paired colorectal cancer tissues and adjacent normal tissues. We then analyzed the association of RNF2 expression with the patients’ clinicopathologic features and prognoses. RNF2 expression was upregulated in colorectal cancer tissues and was associated with the tumor differentiation status, tumor stage and prognosis. In colorectal cancer cell lines, downregulation of RNF2 inhibited cell proliferation and induced apoptosis. Gene microarray analysis revealed that early growth response 1 (EGR1) was upregulated in RNF2-knockdown cells. Knocking down EGR1 partially reversed the inhibition of cell proliferation and the induction of apoptosis in RNF2-knockdown cells. RNF2 was enriched at the EGR1 promoter, where it mono-ubiquitinated histone H2A, thereby inhibiting EGR1 expression. These results indicate that RNF2 is oncogenic in colorectal cancer and may promote disease progression by inhibiting EGR1 expression. RNF2 is thus a potential prognostic marker and therapeutic target in colorectal cancer. Impact Journals 2020-12-19 /pmc/articles/PMC7803491/ /pubmed/33346749 http://dx.doi.org/10.18632/aging.202396 Text en Copyright: © 2020 Wei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wei, Feilong Jing, Haoren Wei, Ming Liu, Lei Wu, Jieheng Wang, Meng Han, Donghui Yang, Fa Yang, Bo Jiao, Dian Zheng, Guoxu Zhang, Lingling Xi, Wenjin Guo, Zhangyan Yang, An-Gang Qin, Weijun Zhou, Yi Wen, Weihong Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 |
title | Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 |
title_full | Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 |
title_fullStr | Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 |
title_full_unstemmed | Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 |
title_short | Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 |
title_sort | ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1 |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803491/ https://www.ncbi.nlm.nih.gov/pubmed/33346749 http://dx.doi.org/10.18632/aging.202396 |
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