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Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research

OBJECTIVES: Since the beginning of the coronavirus disease 2019 pandemic, hundreds of thousands of patients have been treated in ICUs across the globe. The severe acute respiratory syndrome–associated coronavirus 2 virus enters cells via the angiotensin-converting enzyme 2 receptor and activates sev...

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Autores principales: Verhoef, Philip A., Kannan, Sujatha, Sturgill, Jamie L., Tucker, Elizabeth W., Morris, Peter E., Miller, Andrew C., Sexton, Travis R., Koyner, Jay L., Hejal, Rana, Brakenridge, Scott C., Moldawer, Lyle L., Hotchkiss, Richard S., Blood, Teresa M., Mazer, Monty B., Bolesta, Scott, Alexander, Sheila A., Armaignac, Donna Lee, Shein, Steven L., Jones, Christopher, Hoemann, Caroline D., Doctor, Allan, Friess, Stuart H., Parker, Robert I., Rotta, Alexandre T., Remy, Kenneth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994036/
https://www.ncbi.nlm.nih.gov/pubmed/33786450
http://dx.doi.org/10.1097/CCE.0000000000000374
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author Verhoef, Philip A.
Kannan, Sujatha
Sturgill, Jamie L.
Tucker, Elizabeth W.
Morris, Peter E.
Miller, Andrew C.
Sexton, Travis R.
Koyner, Jay L.
Hejal, Rana
Brakenridge, Scott C.
Moldawer, Lyle L.
Hotchkiss, Richard S.
Blood, Teresa M.
Mazer, Monty B.
Bolesta, Scott
Alexander, Sheila A.
Armaignac, Donna Lee
Shein, Steven L.
Jones, Christopher
Hoemann, Caroline D.
Doctor, Allan
Friess, Stuart H.
Parker, Robert I.
Rotta, Alexandre T.
Remy, Kenneth E.
author_facet Verhoef, Philip A.
Kannan, Sujatha
Sturgill, Jamie L.
Tucker, Elizabeth W.
Morris, Peter E.
Miller, Andrew C.
Sexton, Travis R.
Koyner, Jay L.
Hejal, Rana
Brakenridge, Scott C.
Moldawer, Lyle L.
Hotchkiss, Richard S.
Blood, Teresa M.
Mazer, Monty B.
Bolesta, Scott
Alexander, Sheila A.
Armaignac, Donna Lee
Shein, Steven L.
Jones, Christopher
Hoemann, Caroline D.
Doctor, Allan
Friess, Stuart H.
Parker, Robert I.
Rotta, Alexandre T.
Remy, Kenneth E.
author_sort Verhoef, Philip A.
collection PubMed
description OBJECTIVES: Since the beginning of the coronavirus disease 2019 pandemic, hundreds of thousands of patients have been treated in ICUs across the globe. The severe acute respiratory syndrome–associated coronavirus 2 virus enters cells via the angiotensin-converting enzyme 2 receptor and activates several distinct inflammatory pathways, resulting in hematologic abnormalities and dysfunction in respiratory, cardiac, gastrointestinal renal, endocrine, dermatologic, and neurologic systems. This review summarizes the current state of research in coronavirus disease 2019 pathophysiology within the context of potential organ-based disease mechanisms and opportunities for translational research. DATA SOURCES: Investigators from the Research Section of the Society of Critical Care Medicine were selected based on expertise in specific organ systems and research focus. Data were obtained from searches conducted in Medline via the PubMed portal, Directory of Open Access Journals, Excerpta Medica database, Latin American and Caribbean Health Sciences Literature, and Web of Science from an initial search from December 2019 to October 15, 2020, with a revised search to February 3, 2021. The medRxiv, Research Square, and clinical trial registries preprint servers also were searched to limit publication bias. STUDY SELECTION: Content experts selected studies that included mechanism-based relevance to the severe acute respiratory syndrome–associated coronavirus 2 virus or coronavirus disease 2019 disease. DATA EXTRACTION: Not applicable. DATA SYNTHESIS: Not applicable. CONCLUSIONS: Efforts to improve the care of critically ill coronavirus disease 2019 patients should be centered on understanding how severe acute respiratory syndrome–associated coronavirus 2 infection affects organ function. This review articulates specific targets for further research.
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spelling pubmed-79940362021-03-29 Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research Verhoef, Philip A. Kannan, Sujatha Sturgill, Jamie L. Tucker, Elizabeth W. Morris, Peter E. Miller, Andrew C. Sexton, Travis R. Koyner, Jay L. Hejal, Rana Brakenridge, Scott C. Moldawer, Lyle L. Hotchkiss, Richard S. Blood, Teresa M. Mazer, Monty B. Bolesta, Scott Alexander, Sheila A. Armaignac, Donna Lee Shein, Steven L. Jones, Christopher Hoemann, Caroline D. Doctor, Allan Friess, Stuart H. Parker, Robert I. Rotta, Alexandre T. Remy, Kenneth E. Crit Care Explor Review Article OBJECTIVES: Since the beginning of the coronavirus disease 2019 pandemic, hundreds of thousands of patients have been treated in ICUs across the globe. The severe acute respiratory syndrome–associated coronavirus 2 virus enters cells via the angiotensin-converting enzyme 2 receptor and activates several distinct inflammatory pathways, resulting in hematologic abnormalities and dysfunction in respiratory, cardiac, gastrointestinal renal, endocrine, dermatologic, and neurologic systems. This review summarizes the current state of research in coronavirus disease 2019 pathophysiology within the context of potential organ-based disease mechanisms and opportunities for translational research. DATA SOURCES: Investigators from the Research Section of the Society of Critical Care Medicine were selected based on expertise in specific organ systems and research focus. Data were obtained from searches conducted in Medline via the PubMed portal, Directory of Open Access Journals, Excerpta Medica database, Latin American and Caribbean Health Sciences Literature, and Web of Science from an initial search from December 2019 to October 15, 2020, with a revised search to February 3, 2021. The medRxiv, Research Square, and clinical trial registries preprint servers also were searched to limit publication bias. STUDY SELECTION: Content experts selected studies that included mechanism-based relevance to the severe acute respiratory syndrome–associated coronavirus 2 virus or coronavirus disease 2019 disease. DATA EXTRACTION: Not applicable. DATA SYNTHESIS: Not applicable. CONCLUSIONS: Efforts to improve the care of critically ill coronavirus disease 2019 patients should be centered on understanding how severe acute respiratory syndrome–associated coronavirus 2 infection affects organ function. This review articulates specific targets for further research. Lippincott Williams & Wilkins 2021-03-12 /pmc/articles/PMC7994036/ /pubmed/33786450 http://dx.doi.org/10.1097/CCE.0000000000000374 Text en Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Review Article
Verhoef, Philip A.
Kannan, Sujatha
Sturgill, Jamie L.
Tucker, Elizabeth W.
Morris, Peter E.
Miller, Andrew C.
Sexton, Travis R.
Koyner, Jay L.
Hejal, Rana
Brakenridge, Scott C.
Moldawer, Lyle L.
Hotchkiss, Richard S.
Blood, Teresa M.
Mazer, Monty B.
Bolesta, Scott
Alexander, Sheila A.
Armaignac, Donna Lee
Shein, Steven L.
Jones, Christopher
Hoemann, Caroline D.
Doctor, Allan
Friess, Stuart H.
Parker, Robert I.
Rotta, Alexandre T.
Remy, Kenneth E.
Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
title Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
title_full Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
title_fullStr Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
title_full_unstemmed Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
title_short Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
title_sort severe acute respiratory syndrome–associated coronavirus 2 infection and organ dysfunction in the icu: opportunities for translational research
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994036/
https://www.ncbi.nlm.nih.gov/pubmed/33786450
http://dx.doi.org/10.1097/CCE.0000000000000374
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