Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009062/ https://www.ncbi.nlm.nih.gov/pubmed/33790985 http://dx.doi.org/10.1038/s41567-020-0894-9 |
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author | Erzberger, A. Jacobo, A. Dasgupta, A. Hudspeth, A. J. |
author_facet | Erzberger, A. Jacobo, A. Dasgupta, A. Hudspeth, A. J. |
author_sort | Erzberger, A. |
collection | PubMed |
description | Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events — one mediated by biochemical signaling and the other by cellular mechanics — give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ. |
format | Online Article Text |
id | pubmed-8009062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-80090622021-03-30 Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs Erzberger, A. Jacobo, A. Dasgupta, A. Hudspeth, A. J. Nat Phys Article Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events — one mediated by biochemical signaling and the other by cellular mechanics — give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ. 2020-05-11 2020-09 /pmc/articles/PMC8009062/ /pubmed/33790985 http://dx.doi.org/10.1038/s41567-020-0894-9 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Erzberger, A. Jacobo, A. Dasgupta, A. Hudspeth, A. J. Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs |
title | Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs |
title_full | Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs |
title_fullStr | Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs |
title_full_unstemmed | Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs |
title_short | Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs |
title_sort | mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009062/ https://www.ncbi.nlm.nih.gov/pubmed/33790985 http://dx.doi.org/10.1038/s41567-020-0894-9 |
work_keys_str_mv | AT erzbergera mechanochemicalsymmetrybreakingduringmorphogenesisoflaterallinesensoryorgans AT jacoboa mechanochemicalsymmetrybreakingduringmorphogenesisoflaterallinesensoryorgans AT dasguptaa mechanochemicalsymmetrybreakingduringmorphogenesisoflaterallinesensoryorgans AT hudspethaj mechanochemicalsymmetrybreakingduringmorphogenesisoflaterallinesensoryorgans |