Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs

Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation o...

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Detalles Bibliográficos
Autores principales: Erzberger, A., Jacobo, A., Dasgupta, A., Hudspeth, A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009062/
https://www.ncbi.nlm.nih.gov/pubmed/33790985
http://dx.doi.org/10.1038/s41567-020-0894-9
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author Erzberger, A.
Jacobo, A.
Dasgupta, A.
Hudspeth, A. J.
author_facet Erzberger, A.
Jacobo, A.
Dasgupta, A.
Hudspeth, A. J.
author_sort Erzberger, A.
collection PubMed
description Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events — one mediated by biochemical signaling and the other by cellular mechanics — give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ.
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spelling pubmed-80090622021-03-30 Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs Erzberger, A. Jacobo, A. Dasgupta, A. Hudspeth, A. J. Nat Phys Article Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events — one mediated by biochemical signaling and the other by cellular mechanics — give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ. 2020-05-11 2020-09 /pmc/articles/PMC8009062/ /pubmed/33790985 http://dx.doi.org/10.1038/s41567-020-0894-9 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Erzberger, A.
Jacobo, A.
Dasgupta, A.
Hudspeth, A. J.
Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
title Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
title_full Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
title_fullStr Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
title_full_unstemmed Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
title_short Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
title_sort mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009062/
https://www.ncbi.nlm.nih.gov/pubmed/33790985
http://dx.doi.org/10.1038/s41567-020-0894-9
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