Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity

T cells undergo metabolic reprogramming and multiple biological processes to satisfy their energetic and biosynthetic demands throughout their lifespan. Several of these metabolic pathways result in the generation of reactive oxygen species (ROS). The imbalance between ROS generation and scavenging...

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Autores principales: Peng, Hao-Yun, Lucavs, Jason, Ballard, Darby, Das, Jugal Kishore, Kumar, Anil, Wang, Liqing, Ren, Yijie, Xiong, Xiaofang, Song, Jianxun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044852/
https://www.ncbi.nlm.nih.gov/pubmed/33868291
http://dx.doi.org/10.3389/fimmu.2021.652687
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author Peng, Hao-Yun
Lucavs, Jason
Ballard, Darby
Das, Jugal Kishore
Kumar, Anil
Wang, Liqing
Ren, Yijie
Xiong, Xiaofang
Song, Jianxun
author_facet Peng, Hao-Yun
Lucavs, Jason
Ballard, Darby
Das, Jugal Kishore
Kumar, Anil
Wang, Liqing
Ren, Yijie
Xiong, Xiaofang
Song, Jianxun
author_sort Peng, Hao-Yun
collection PubMed
description T cells undergo metabolic reprogramming and multiple biological processes to satisfy their energetic and biosynthetic demands throughout their lifespan. Several of these metabolic pathways result in the generation of reactive oxygen species (ROS). The imbalance between ROS generation and scavenging could result in severe damage to the cells and potential cell death, ultimately leading to T cell-related diseases. Interestingly, ROS play an essential role in T cell immunity. Here, we introduce the important connectivity between T cell lifespan and the metabolic reprogramming among distinct T cell subsets. We also discuss the generation and sources of ROS production within T cell immunity as well as highlight recent research concerning the effects of ROS on T cell activities.
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spelling pubmed-80448522021-04-15 Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity Peng, Hao-Yun Lucavs, Jason Ballard, Darby Das, Jugal Kishore Kumar, Anil Wang, Liqing Ren, Yijie Xiong, Xiaofang Song, Jianxun Front Immunol Immunology T cells undergo metabolic reprogramming and multiple biological processes to satisfy their energetic and biosynthetic demands throughout their lifespan. Several of these metabolic pathways result in the generation of reactive oxygen species (ROS). The imbalance between ROS generation and scavenging could result in severe damage to the cells and potential cell death, ultimately leading to T cell-related diseases. Interestingly, ROS play an essential role in T cell immunity. Here, we introduce the important connectivity between T cell lifespan and the metabolic reprogramming among distinct T cell subsets. We also discuss the generation and sources of ROS production within T cell immunity as well as highlight recent research concerning the effects of ROS on T cell activities. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8044852/ /pubmed/33868291 http://dx.doi.org/10.3389/fimmu.2021.652687 Text en Copyright © 2021 Peng, Lucavs, Ballard, Das, Kumar, Wang, Ren, Xiong and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Peng, Hao-Yun
Lucavs, Jason
Ballard, Darby
Das, Jugal Kishore
Kumar, Anil
Wang, Liqing
Ren, Yijie
Xiong, Xiaofang
Song, Jianxun
Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity
title Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity
title_full Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity
title_fullStr Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity
title_full_unstemmed Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity
title_short Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity
title_sort metabolic reprogramming and reactive oxygen species in t cell immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044852/
https://www.ncbi.nlm.nih.gov/pubmed/33868291
http://dx.doi.org/10.3389/fimmu.2021.652687
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