Green Synthesis of Zinc Oxide (ZnO) Nanoparticles Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications
[Image: see text] In the present work, bioaugmented zinc oxide nanoparticles (ZnO-NPs) were prepared from aqueous fruit extracts of Myristica fragrans. The ZnO-NPs were characterized by different techniques such as X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, ultraviolet...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047667/ https://www.ncbi.nlm.nih.gov/pubmed/33869951 http://dx.doi.org/10.1021/acsomega.1c00310 |
_version_ | 1783679087081947136 |
---|---|
author | Faisal, Shah Jan, Hasnain Shah, Sajjad Ali Shah, Sumaira Khan, Adnan Akbar, Muhammad Taj Rizwan, Muhammad Jan, Faheem Wajidullah, Akhtar, Noreen Khattak, Aishma Syed, Suliman |
author_facet | Faisal, Shah Jan, Hasnain Shah, Sajjad Ali Shah, Sumaira Khan, Adnan Akbar, Muhammad Taj Rizwan, Muhammad Jan, Faheem Wajidullah, Akhtar, Noreen Khattak, Aishma Syed, Suliman |
author_sort | Faisal, Shah |
collection | PubMed |
description | [Image: see text] In the present work, bioaugmented zinc oxide nanoparticles (ZnO-NPs) were prepared from aqueous fruit extracts of Myristica fragrans. The ZnO-NPs were characterized by different techniques such as X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, ultraviolet (UV) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and thermogravimetric analysis (TGA). The crystallites exhibited a mean size of 41.23 nm measured via XRD and were highly pure, while SEM and TEM analyses of synthesized NPs confirmed their spherical or elliptical shape. The functional groups responsible for stabilizing and capping of ZnO-NPs were confirmed using FTIR analysis. The ζ-size and ζ-potential of synthesized ZnO-NPs were reported as 66 nm and −22.1 mV, respectively, via the DLS technique can be considered as moderate stable colloidal solution. Synthesized NPs were used to evaluate for their possible antibacterial, antidiabetic, antioxidant, antiparasitic, and larvicidal properties. The NPs were found to be highly active against bacterial strains both coated with antibiotics and alone. Klebsiella pneumoniae was found to be the most sensitive strain against NPs (27 ± 1.73) and against NPs coated with imipinem (26 ± 1.5). ZnO-NPs displayed outstanding inhibitory potential against enzymes protein kinase (12.23 ± 0.42), α-amylase (73.23 ± 0.42), and α-glucosidase (65.21 ± 0.49). Overall, the synthesized NPs have shown significant larvicidal activity (77.3 ± 1.8) against Aedes aegypti, the mosquitoes involved in the transmission of dengue fever. Similarly, tremendous leishmanicidal activity was also observed against both the promastigote (71.50 ± 0.70) and amastigote (61.41 ± 0.71) forms of the parasite. The biosynthesized NPs were found to be excellent antioxidant and biocompatible nanomaterials. Biosynthesized ZnO-NPs were also used as photocatalytic agents, resulting in 88% degradation of methylene blue dye in 140 min. Owing to their eco-friendly synthesis, nontoxicity, and biocompatible nature, ZnO-NPs synthesized from M. fragrans can be exploited as potential candidates for biomedical and environmental applications. |
format | Online Article Text |
id | pubmed-8047667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-80476672021-04-16 Green Synthesis of Zinc Oxide (ZnO) Nanoparticles Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications Faisal, Shah Jan, Hasnain Shah, Sajjad Ali Shah, Sumaira Khan, Adnan Akbar, Muhammad Taj Rizwan, Muhammad Jan, Faheem Wajidullah, Akhtar, Noreen Khattak, Aishma Syed, Suliman ACS Omega [Image: see text] In the present work, bioaugmented zinc oxide nanoparticles (ZnO-NPs) were prepared from aqueous fruit extracts of Myristica fragrans. The ZnO-NPs were characterized by different techniques such as X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, ultraviolet (UV) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and thermogravimetric analysis (TGA). The crystallites exhibited a mean size of 41.23 nm measured via XRD and were highly pure, while SEM and TEM analyses of synthesized NPs confirmed their spherical or elliptical shape. The functional groups responsible for stabilizing and capping of ZnO-NPs were confirmed using FTIR analysis. The ζ-size and ζ-potential of synthesized ZnO-NPs were reported as 66 nm and −22.1 mV, respectively, via the DLS technique can be considered as moderate stable colloidal solution. Synthesized NPs were used to evaluate for their possible antibacterial, antidiabetic, antioxidant, antiparasitic, and larvicidal properties. The NPs were found to be highly active against bacterial strains both coated with antibiotics and alone. Klebsiella pneumoniae was found to be the most sensitive strain against NPs (27 ± 1.73) and against NPs coated with imipinem (26 ± 1.5). ZnO-NPs displayed outstanding inhibitory potential against enzymes protein kinase (12.23 ± 0.42), α-amylase (73.23 ± 0.42), and α-glucosidase (65.21 ± 0.49). Overall, the synthesized NPs have shown significant larvicidal activity (77.3 ± 1.8) against Aedes aegypti, the mosquitoes involved in the transmission of dengue fever. Similarly, tremendous leishmanicidal activity was also observed against both the promastigote (71.50 ± 0.70) and amastigote (61.41 ± 0.71) forms of the parasite. The biosynthesized NPs were found to be excellent antioxidant and biocompatible nanomaterials. Biosynthesized ZnO-NPs were also used as photocatalytic agents, resulting in 88% degradation of methylene blue dye in 140 min. Owing to their eco-friendly synthesis, nontoxicity, and biocompatible nature, ZnO-NPs synthesized from M. fragrans can be exploited as potential candidates for biomedical and environmental applications. American Chemical Society 2021-03-30 /pmc/articles/PMC8047667/ /pubmed/33869951 http://dx.doi.org/10.1021/acsomega.1c00310 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Faisal, Shah Jan, Hasnain Shah, Sajjad Ali Shah, Sumaira Khan, Adnan Akbar, Muhammad Taj Rizwan, Muhammad Jan, Faheem Wajidullah, Akhtar, Noreen Khattak, Aishma Syed, Suliman Green Synthesis of Zinc Oxide (ZnO) Nanoparticles Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications |
title | Green Synthesis of Zinc Oxide (ZnO) Nanoparticles
Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications |
title_full | Green Synthesis of Zinc Oxide (ZnO) Nanoparticles
Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications |
title_fullStr | Green Synthesis of Zinc Oxide (ZnO) Nanoparticles
Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications |
title_full_unstemmed | Green Synthesis of Zinc Oxide (ZnO) Nanoparticles
Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications |
title_short | Green Synthesis of Zinc Oxide (ZnO) Nanoparticles
Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications |
title_sort | green synthesis of zinc oxide (zno) nanoparticles
using aqueous fruit extracts of myristica fragrans: their characterizations and biological and environmental applications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047667/ https://www.ncbi.nlm.nih.gov/pubmed/33869951 http://dx.doi.org/10.1021/acsomega.1c00310 |
work_keys_str_mv | AT faisalshah greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT janhasnain greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT shahsajjadali greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT shahsumaira greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT khanadnan greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT akbarmuhammadtaj greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT rizwanmuhammad greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT janfaheem greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT wajidullah greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT akhtarnoreen greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT khattakaishma greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications AT syedsuliman greensynthesisofzincoxideznonanoparticlesusingaqueousfruitextractsofmyristicafragranstheircharacterizationsandbiologicalandenvironmentalapplications |