The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines

Schizophrenia is a common debilitating disease characterized by continuous or relapsing episodes of psychosis. Although the molecular mechanisms underlying this psychiatric illness remain incompletely understood, a growing body of clinical, pharmacological, and genetic evidence suggests that G prote...

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Autores principales: Boczek, Tomasz, Mackiewicz, Joanna, Sobolczyk, Marta, Wawrzyniak, Julia, Lisek, Malwina, Ferenc, Bozena, Guo, Feng, Zylinska, Ludmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155952/
https://www.ncbi.nlm.nih.gov/pubmed/34067760
http://dx.doi.org/10.3390/cells10051228
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author Boczek, Tomasz
Mackiewicz, Joanna
Sobolczyk, Marta
Wawrzyniak, Julia
Lisek, Malwina
Ferenc, Bozena
Guo, Feng
Zylinska, Ludmila
author_facet Boczek, Tomasz
Mackiewicz, Joanna
Sobolczyk, Marta
Wawrzyniak, Julia
Lisek, Malwina
Ferenc, Bozena
Guo, Feng
Zylinska, Ludmila
author_sort Boczek, Tomasz
collection PubMed
description Schizophrenia is a common debilitating disease characterized by continuous or relapsing episodes of psychosis. Although the molecular mechanisms underlying this psychiatric illness remain incompletely understood, a growing body of clinical, pharmacological, and genetic evidence suggests that G protein-coupled receptors (GPCRs) play a critical role in disease development, progression, and treatment. This pivotal role is further highlighted by the fact that GPCRs are the most common targets for antipsychotic drugs. The GPCRs activation evokes slow synaptic transmission through several downstream pathways, many of them engaging intracellular Ca(2+) mobilization. Dysfunctions of the neurotransmitter systems involving the action of GPCRs in the frontal and limbic-related regions are likely to underly the complex picture that includes the whole spectrum of positive and negative schizophrenia symptoms. Therefore, the progress in our understanding of GPCRs function in the control of brain cognitive functions is expected to open new avenues for selective drug development. In this paper, we review and synthesize the recent data regarding the contribution of neurotransmitter-GPCRs signaling to schizophrenia symptomology.
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spelling pubmed-81559522021-05-28 The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines Boczek, Tomasz Mackiewicz, Joanna Sobolczyk, Marta Wawrzyniak, Julia Lisek, Malwina Ferenc, Bozena Guo, Feng Zylinska, Ludmila Cells Review Schizophrenia is a common debilitating disease characterized by continuous or relapsing episodes of psychosis. Although the molecular mechanisms underlying this psychiatric illness remain incompletely understood, a growing body of clinical, pharmacological, and genetic evidence suggests that G protein-coupled receptors (GPCRs) play a critical role in disease development, progression, and treatment. This pivotal role is further highlighted by the fact that GPCRs are the most common targets for antipsychotic drugs. The GPCRs activation evokes slow synaptic transmission through several downstream pathways, many of them engaging intracellular Ca(2+) mobilization. Dysfunctions of the neurotransmitter systems involving the action of GPCRs in the frontal and limbic-related regions are likely to underly the complex picture that includes the whole spectrum of positive and negative schizophrenia symptoms. Therefore, the progress in our understanding of GPCRs function in the control of brain cognitive functions is expected to open new avenues for selective drug development. In this paper, we review and synthesize the recent data regarding the contribution of neurotransmitter-GPCRs signaling to schizophrenia symptomology. MDPI 2021-05-17 /pmc/articles/PMC8155952/ /pubmed/34067760 http://dx.doi.org/10.3390/cells10051228 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boczek, Tomasz
Mackiewicz, Joanna
Sobolczyk, Marta
Wawrzyniak, Julia
Lisek, Malwina
Ferenc, Bozena
Guo, Feng
Zylinska, Ludmila
The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
title The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
title_full The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
title_fullStr The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
title_full_unstemmed The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
title_short The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
title_sort role of g protein-coupled receptors (gpcrs) and calcium signaling in schizophrenia. focus on gpcrs activated by neurotransmitters and chemokines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155952/
https://www.ncbi.nlm.nih.gov/pubmed/34067760
http://dx.doi.org/10.3390/cells10051228
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