Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change
Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tam...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164584/ https://www.ncbi.nlm.nih.gov/pubmed/33611659 http://dx.doi.org/10.1007/s00109-021-02047-5 |
_version_ | 1783701148054585344 |
---|---|
author | Mao, Misha Hu, Dengdi Yang, Jingjing Chen, Yongxia Zhang, Xun Shen, Jianguo Teng, Rongyue Zhou, Jichun Wang, Linbo |
author_facet | Mao, Misha Hu, Dengdi Yang, Jingjing Chen, Yongxia Zhang, Xun Shen, Jianguo Teng, Rongyue Zhou, Jichun Wang, Linbo |
author_sort | Mao, Misha |
collection | PubMed |
description | Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tamoxifen resistance are unclear. Curcumin has attracted considerable attention in the last decades. It is isolated from Curcuma longa and has beneficial effects in cancer therapy. We studied this property by using MCF-7 and tamoxifen-resistant breast cancer cells (MCF-7/TAM) cell lines. PLAC8 can regulate MCF-7/TAM cell drug sensitivity through the MAPK/ERK pathway and shows the potential effects of curcumin or as a possible druggable target against tamoxifen failure. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00109-021-02047-5. |
format | Online Article Text |
id | pubmed-8164584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-81645842021-06-17 Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change Mao, Misha Hu, Dengdi Yang, Jingjing Chen, Yongxia Zhang, Xun Shen, Jianguo Teng, Rongyue Zhou, Jichun Wang, Linbo J Mol Med (Berl) Original Article Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tamoxifen resistance are unclear. Curcumin has attracted considerable attention in the last decades. It is isolated from Curcuma longa and has beneficial effects in cancer therapy. We studied this property by using MCF-7 and tamoxifen-resistant breast cancer cells (MCF-7/TAM) cell lines. PLAC8 can regulate MCF-7/TAM cell drug sensitivity through the MAPK/ERK pathway and shows the potential effects of curcumin or as a possible druggable target against tamoxifen failure. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00109-021-02047-5. Springer Berlin Heidelberg 2021-02-21 2021 /pmc/articles/PMC8164584/ /pubmed/33611659 http://dx.doi.org/10.1007/s00109-021-02047-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Mao, Misha Hu, Dengdi Yang, Jingjing Chen, Yongxia Zhang, Xun Shen, Jianguo Teng, Rongyue Zhou, Jichun Wang, Linbo Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change |
title | Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change |
title_full | Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change |
title_fullStr | Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change |
title_full_unstemmed | Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change |
title_short | Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change |
title_sort | regulation of tamoxifen sensitivity by the plac8/mapk pathway axis is antagonized by curcumin-induced protein stability change |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164584/ https://www.ncbi.nlm.nih.gov/pubmed/33611659 http://dx.doi.org/10.1007/s00109-021-02047-5 |
work_keys_str_mv | AT maomisha regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT hudengdi regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT yangjingjing regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT chenyongxia regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT zhangxun regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT shenjianguo regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT tengrongyue regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT zhoujichun regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange AT wanglinbo regulationoftamoxifensensitivitybytheplac8mapkpathwayaxisisantagonizedbycurcumininducedproteinstabilitychange |