Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change

Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tam...

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Autores principales: Mao, Misha, Hu, Dengdi, Yang, Jingjing, Chen, Yongxia, Zhang, Xun, Shen, Jianguo, Teng, Rongyue, Zhou, Jichun, Wang, Linbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164584/
https://www.ncbi.nlm.nih.gov/pubmed/33611659
http://dx.doi.org/10.1007/s00109-021-02047-5
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author Mao, Misha
Hu, Dengdi
Yang, Jingjing
Chen, Yongxia
Zhang, Xun
Shen, Jianguo
Teng, Rongyue
Zhou, Jichun
Wang, Linbo
author_facet Mao, Misha
Hu, Dengdi
Yang, Jingjing
Chen, Yongxia
Zhang, Xun
Shen, Jianguo
Teng, Rongyue
Zhou, Jichun
Wang, Linbo
author_sort Mao, Misha
collection PubMed
description Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tamoxifen resistance are unclear. Curcumin has attracted considerable attention in the last decades. It is isolated from Curcuma longa and has beneficial effects in cancer therapy. We studied this property by using MCF-7 and tamoxifen-resistant breast cancer cells (MCF-7/TAM) cell lines. PLAC8 can regulate MCF-7/TAM cell drug sensitivity through the MAPK/ERK pathway and shows the potential effects of curcumin or as a possible druggable target against tamoxifen failure. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00109-021-02047-5.
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spelling pubmed-81645842021-06-17 Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change Mao, Misha Hu, Dengdi Yang, Jingjing Chen, Yongxia Zhang, Xun Shen, Jianguo Teng, Rongyue Zhou, Jichun Wang, Linbo J Mol Med (Berl) Original Article Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tamoxifen resistance are unclear. Curcumin has attracted considerable attention in the last decades. It is isolated from Curcuma longa and has beneficial effects in cancer therapy. We studied this property by using MCF-7 and tamoxifen-resistant breast cancer cells (MCF-7/TAM) cell lines. PLAC8 can regulate MCF-7/TAM cell drug sensitivity through the MAPK/ERK pathway and shows the potential effects of curcumin or as a possible druggable target against tamoxifen failure. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00109-021-02047-5. Springer Berlin Heidelberg 2021-02-21 2021 /pmc/articles/PMC8164584/ /pubmed/33611659 http://dx.doi.org/10.1007/s00109-021-02047-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Mao, Misha
Hu, Dengdi
Yang, Jingjing
Chen, Yongxia
Zhang, Xun
Shen, Jianguo
Teng, Rongyue
Zhou, Jichun
Wang, Linbo
Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change
title Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change
title_full Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change
title_fullStr Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change
title_full_unstemmed Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change
title_short Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change
title_sort regulation of tamoxifen sensitivity by the plac8/mapk pathway axis is antagonized by curcumin-induced protein stability change
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164584/
https://www.ncbi.nlm.nih.gov/pubmed/33611659
http://dx.doi.org/10.1007/s00109-021-02047-5
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