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Freeze–thaw characterization process to minimize aggregation and enable drug product manufacturing of protein based therapeutics
Physical instabilities of proteins in the form of protein aggregation continue to be a major challenge in the development of protein drug candidates. Aggregation can occur during different stages of product lifecycle such as freeze–thaw, manufacturing, shipping, and storage, and can potentially dela...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166975/ https://www.ncbi.nlm.nih.gov/pubmed/34059716 http://dx.doi.org/10.1038/s41598-021-90772-9 |