Freeze–thaw characterization process to minimize aggregation and enable drug product manufacturing of protein based therapeutics
Physical instabilities of proteins in the form of protein aggregation continue to be a major challenge in the development of protein drug candidates. Aggregation can occur during different stages of product lifecycle such as freeze–thaw, manufacturing, shipping, and storage, and can potentially dela...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166975/ https://www.ncbi.nlm.nih.gov/pubmed/34059716 http://dx.doi.org/10.1038/s41598-021-90772-9 |