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The complex roles of neutrophils in APAP‐induced liver injury

Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune ce...

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Detalles Bibliográficos
Autores principales: Guo, Huiting, Chen, Shiwei, Xie, Mingjie, Zhou, Cheng, Zheng, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168408/
https://www.ncbi.nlm.nih.gov/pubmed/33942422
http://dx.doi.org/10.1111/cpr.13040
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author Guo, Huiting
Chen, Shiwei
Xie, Mingjie
Zhou, Cheng
Zheng, Min
author_facet Guo, Huiting
Chen, Shiwei
Xie, Mingjie
Zhou, Cheng
Zheng, Min
author_sort Guo, Huiting
collection PubMed
description Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune cells in human serving as the first barrier against the invasion of pathogen. It has been reported that neutrophils patriciate in the occurrence and development of APAP‐induced liver injury. However, evolving evidences suggest that neutrophils also contribute to tissue repair and actively orchestrate resolution of inflammation. Here, we addressed the complex roles in APAP‐induced liver injury on the basis of brief introduction of neutrophil's activation, recruitment and migration.
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spelling pubmed-81684082021-06-05 The complex roles of neutrophils in APAP‐induced liver injury Guo, Huiting Chen, Shiwei Xie, Mingjie Zhou, Cheng Zheng, Min Cell Prolif Review Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune cells in human serving as the first barrier against the invasion of pathogen. It has been reported that neutrophils patriciate in the occurrence and development of APAP‐induced liver injury. However, evolving evidences suggest that neutrophils also contribute to tissue repair and actively orchestrate resolution of inflammation. Here, we addressed the complex roles in APAP‐induced liver injury on the basis of brief introduction of neutrophil's activation, recruitment and migration. John Wiley and Sons Inc. 2021-05-04 /pmc/articles/PMC8168408/ /pubmed/33942422 http://dx.doi.org/10.1111/cpr.13040 Text en © 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Guo, Huiting
Chen, Shiwei
Xie, Mingjie
Zhou, Cheng
Zheng, Min
The complex roles of neutrophils in APAP‐induced liver injury
title The complex roles of neutrophils in APAP‐induced liver injury
title_full The complex roles of neutrophils in APAP‐induced liver injury
title_fullStr The complex roles of neutrophils in APAP‐induced liver injury
title_full_unstemmed The complex roles of neutrophils in APAP‐induced liver injury
title_short The complex roles of neutrophils in APAP‐induced liver injury
title_sort complex roles of neutrophils in apap‐induced liver injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168408/
https://www.ncbi.nlm.nih.gov/pubmed/33942422
http://dx.doi.org/10.1111/cpr.13040
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