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The complex roles of neutrophils in APAP‐induced liver injury
Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune ce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168408/ https://www.ncbi.nlm.nih.gov/pubmed/33942422 http://dx.doi.org/10.1111/cpr.13040 |
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author | Guo, Huiting Chen, Shiwei Xie, Mingjie Zhou, Cheng Zheng, Min |
author_facet | Guo, Huiting Chen, Shiwei Xie, Mingjie Zhou, Cheng Zheng, Min |
author_sort | Guo, Huiting |
collection | PubMed |
description | Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune cells in human serving as the first barrier against the invasion of pathogen. It has been reported that neutrophils patriciate in the occurrence and development of APAP‐induced liver injury. However, evolving evidences suggest that neutrophils also contribute to tissue repair and actively orchestrate resolution of inflammation. Here, we addressed the complex roles in APAP‐induced liver injury on the basis of brief introduction of neutrophil's activation, recruitment and migration. |
format | Online Article Text |
id | pubmed-8168408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81684082021-06-05 The complex roles of neutrophils in APAP‐induced liver injury Guo, Huiting Chen, Shiwei Xie, Mingjie Zhou, Cheng Zheng, Min Cell Prolif Review Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune cells in human serving as the first barrier against the invasion of pathogen. It has been reported that neutrophils patriciate in the occurrence and development of APAP‐induced liver injury. However, evolving evidences suggest that neutrophils also contribute to tissue repair and actively orchestrate resolution of inflammation. Here, we addressed the complex roles in APAP‐induced liver injury on the basis of brief introduction of neutrophil's activation, recruitment and migration. John Wiley and Sons Inc. 2021-05-04 /pmc/articles/PMC8168408/ /pubmed/33942422 http://dx.doi.org/10.1111/cpr.13040 Text en © 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Guo, Huiting Chen, Shiwei Xie, Mingjie Zhou, Cheng Zheng, Min The complex roles of neutrophils in APAP‐induced liver injury |
title | The complex roles of neutrophils in APAP‐induced liver injury |
title_full | The complex roles of neutrophils in APAP‐induced liver injury |
title_fullStr | The complex roles of neutrophils in APAP‐induced liver injury |
title_full_unstemmed | The complex roles of neutrophils in APAP‐induced liver injury |
title_short | The complex roles of neutrophils in APAP‐induced liver injury |
title_sort | complex roles of neutrophils in apap‐induced liver injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168408/ https://www.ncbi.nlm.nih.gov/pubmed/33942422 http://dx.doi.org/10.1111/cpr.13040 |
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