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Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis

Metastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multi...

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Autores principales: Hipólito, Ana, Martins, Filipa, Mendes, Cindy, Lopes-Coelho, Filipa, Serpa, Jacinta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209414/
https://www.ncbi.nlm.nih.gov/pubmed/34150624
http://dx.doi.org/10.3389/fonc.2021.656851
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author Hipólito, Ana
Martins, Filipa
Mendes, Cindy
Lopes-Coelho, Filipa
Serpa, Jacinta
author_facet Hipólito, Ana
Martins, Filipa
Mendes, Cindy
Lopes-Coelho, Filipa
Serpa, Jacinta
author_sort Hipólito, Ana
collection PubMed
description Metastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multistep process encompasses the dissemination of cancer cells to distant organs, followed by their adaptation to foreign microenvironments and establishment in secondary tumors. During the last decades, it was discovered that these events may be favored by particular metabolic patterns, which are dependent on reprogrammed signaling pathways in cancer cells while they acquire metastatic traits. In this review, we present current knowledge of molecular mechanisms that coordinate the crosstalk between metastatic signaling and cellular metabolism. The recent findings involving the contribution of crucial metabolic pathways involved in the bioenergetics and biosynthesis control in metastatic cells are summarized. Finally, we highlight new promising metabolism-based therapeutic strategies as a putative way of impairing metastasis.
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spelling pubmed-82094142021-06-18 Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis Hipólito, Ana Martins, Filipa Mendes, Cindy Lopes-Coelho, Filipa Serpa, Jacinta Front Oncol Oncology Metastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multistep process encompasses the dissemination of cancer cells to distant organs, followed by their adaptation to foreign microenvironments and establishment in secondary tumors. During the last decades, it was discovered that these events may be favored by particular metabolic patterns, which are dependent on reprogrammed signaling pathways in cancer cells while they acquire metastatic traits. In this review, we present current knowledge of molecular mechanisms that coordinate the crosstalk between metastatic signaling and cellular metabolism. The recent findings involving the contribution of crucial metabolic pathways involved in the bioenergetics and biosynthesis control in metastatic cells are summarized. Finally, we highlight new promising metabolism-based therapeutic strategies as a putative way of impairing metastasis. Frontiers Media S.A. 2021-06-03 /pmc/articles/PMC8209414/ /pubmed/34150624 http://dx.doi.org/10.3389/fonc.2021.656851 Text en Copyright © 2021 Hipólito, Martins, Mendes, Lopes-Coelho and Serpa https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hipólito, Ana
Martins, Filipa
Mendes, Cindy
Lopes-Coelho, Filipa
Serpa, Jacinta
Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
title Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
title_full Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
title_fullStr Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
title_full_unstemmed Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
title_short Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
title_sort molecular and metabolic reprogramming: pulling the strings toward tumor metastasis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209414/
https://www.ncbi.nlm.nih.gov/pubmed/34150624
http://dx.doi.org/10.3389/fonc.2021.656851
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