Curcumin and Its Potential Impact on Microbiota

Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effect...

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Autores principales: Jabczyk, Marzena, Nowak, Justyna, Hudzik, Bartosz, Zubelewicz-Szkodzińska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230423/
https://www.ncbi.nlm.nih.gov/pubmed/34200819
http://dx.doi.org/10.3390/nu13062004
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author Jabczyk, Marzena
Nowak, Justyna
Hudzik, Bartosz
Zubelewicz-Szkodzińska, Barbara
author_facet Jabczyk, Marzena
Nowak, Justyna
Hudzik, Bartosz
Zubelewicz-Szkodzińska, Barbara
author_sort Jabczyk, Marzena
collection PubMed
description Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact.
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spelling pubmed-82304232021-06-26 Curcumin and Its Potential Impact on Microbiota Jabczyk, Marzena Nowak, Justyna Hudzik, Bartosz Zubelewicz-Szkodzińska, Barbara Nutrients Review Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact. MDPI 2021-06-10 /pmc/articles/PMC8230423/ /pubmed/34200819 http://dx.doi.org/10.3390/nu13062004 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jabczyk, Marzena
Nowak, Justyna
Hudzik, Bartosz
Zubelewicz-Szkodzińska, Barbara
Curcumin and Its Potential Impact on Microbiota
title Curcumin and Its Potential Impact on Microbiota
title_full Curcumin and Its Potential Impact on Microbiota
title_fullStr Curcumin and Its Potential Impact on Microbiota
title_full_unstemmed Curcumin and Its Potential Impact on Microbiota
title_short Curcumin and Its Potential Impact on Microbiota
title_sort curcumin and its potential impact on microbiota
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230423/
https://www.ncbi.nlm.nih.gov/pubmed/34200819
http://dx.doi.org/10.3390/nu13062004
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