Curcumin and Its Potential Impact on Microbiota
Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effect...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230423/ https://www.ncbi.nlm.nih.gov/pubmed/34200819 http://dx.doi.org/10.3390/nu13062004 |
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author | Jabczyk, Marzena Nowak, Justyna Hudzik, Bartosz Zubelewicz-Szkodzińska, Barbara |
author_facet | Jabczyk, Marzena Nowak, Justyna Hudzik, Bartosz Zubelewicz-Szkodzińska, Barbara |
author_sort | Jabczyk, Marzena |
collection | PubMed |
description | Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact. |
format | Online Article Text |
id | pubmed-8230423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82304232021-06-26 Curcumin and Its Potential Impact on Microbiota Jabczyk, Marzena Nowak, Justyna Hudzik, Bartosz Zubelewicz-Szkodzińska, Barbara Nutrients Review Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact. MDPI 2021-06-10 /pmc/articles/PMC8230423/ /pubmed/34200819 http://dx.doi.org/10.3390/nu13062004 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jabczyk, Marzena Nowak, Justyna Hudzik, Bartosz Zubelewicz-Szkodzińska, Barbara Curcumin and Its Potential Impact on Microbiota |
title | Curcumin and Its Potential Impact on Microbiota |
title_full | Curcumin and Its Potential Impact on Microbiota |
title_fullStr | Curcumin and Its Potential Impact on Microbiota |
title_full_unstemmed | Curcumin and Its Potential Impact on Microbiota |
title_short | Curcumin and Its Potential Impact on Microbiota |
title_sort | curcumin and its potential impact on microbiota |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230423/ https://www.ncbi.nlm.nih.gov/pubmed/34200819 http://dx.doi.org/10.3390/nu13062004 |
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