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Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
OBJECTIVE: To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN: Randomised controlled, adaptive, open label clinical trial. SETTING: 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, Uni...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515466/ https://www.ncbi.nlm.nih.gov/pubmed/34649864 http://dx.doi.org/10.1136/bmj.n2400 |
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author | Sholzberg, Michelle Tang, Grace H Rahhal, Hassan AlHamzah, Musaad Kreuziger, Lisa Baumann Áinle, Fionnuala Ní Alomran, Faris Alayed, Khalid Alsheef, Mohammed AlSumait, Fahad Pompilio, Carlos Eduardo Sperlich, Catherine Tangri, Sabrena Tang, Terence Jaksa, Peter Suryanarayan, Deepa Almarshoodi, Mozah Castellucci, Lana A James, Paula D Lillicrap, David Carrier, Marc Beckett, Andrew Colovos, Christos Jayakar, Jai Arsenault, Marie-Pier Wu, Cynthia Doyon, Karine Andreou, E Roseann Dounaevskaia, Vera Tseng, Eric K Lim, Gloria Fralick, Michael Middeldorp, Saskia Lee, Agnes Y Y Zuo, Fei da Costa, Bruno R Thorpe, Kevin E Negri, Elnara Márcia Cushman, Mary Jüni, Peter Laupacis, Andreas Lin, Yulia Day, Andrew Rochwerg, Bram Abdulrehman, Jameel Gergi, Mansour Kondo, Rodrigo Hidd Piloto, Bruna Mamprim de Abreu Pereira, Guilherme Valente, Fernando Salvetti Agreda, Ariel Fernando Villarroel Munoz Torres, Pablo Andres Moraes, Maíra Oliveira de Lucena Moreira, Claudia Neto, Fernando Galassi Stocco Baptista, Fabíola Vieira Duarte Moreira, Joanne Alves Ferreira, Augusto Séttemo Frudit, Paula Martinez, Gabriel Souza, Heraldo Possolo Neto, Rodrigo Antônio Brandão d'Amico, Elbio Antonio Padrão, Eduardo Messias Hirano Sarin da Mota e Albuquerque, Fernando Zangrossi, Giovanna Villela Kanasiro, Alberto Kendy Cincoto, Alissom Vitti de Souza Reis, Hugo Arias da Silva, Vitor Miyashiro Bellintani, Arthur Petrillo dos Santos Pereira, Vivian de Oliveira, Yohan Washington Carvalho, Bárbara Justo de Souza Novaes, Mariana Silveira, Henrique Brito de Avelar, Gabriel César Alves Mota, Lara Bonanni Caciola, Karina Marim, Matheus de Arêa Leão Freire Monsalvarga, Tales Cabral Blanco Santos, Alexandre Salgado Haydar, Ahmed Saraiva, Gabriella Seixas Sampaio da Costa Ribeiro, Sabrina Correa Meirelles Marchini, Julio Flavio de Alencar, Julio Cesar Garcia de Seixas Santos, Ana Catharina Millette, Caroline Lebeau, Mathieu Devaux, Céline Boutin, Mélina Nguyen, Trung Nghia Srour, Line de Angelis, Flavia Fugulin, Mariane Binnie, Alexandra Bejaimal, Shayna A.D. Binding, Andrew Marticorena, Rosa M. Ginocchio, Galo Kaplovitch, Eric Rymaszewski, Klaudia Raissi, Afsaneh Falappa, Marcelo Ernst, Blair Ali, Amna Romano, Martin Khurram, Mobina Kim, Christie Kapur, Ajay Edwards, Michelle Swarup, Vidushi Camilotti, Bruna Jani, Jiten Carter, Jeff Gillrie, Mark R. Sidhu, Davinder Robinson, Traci Stutely, Krystina Watpool, Irene Porteous, Rebecca Jao, Kevin Boudreault-Pedneault, Jean-Samuel Kandel, Christopher Taylor, Maureen T. Choo, Wei En Enoch Parsons, Laura Dowbenka, Ann Ramonas, Gitana Nikitin, Sergey Patterson, Jeffery Hnatiuk, Mark Tapardel, Anca Lapner, Sarah Takach Carpenter, Thirza Rackel, Lori Cairns, Rebecca Pinder, Jessica Anglin, Peter McPherson, Catherine Chiverton, Liselle Barbosa, David Loukiantchenko, Shany Shamiss, Yana Tassy, Danaë Shivakumar, Sudeep Keating, Mary-Margaret Pleasance, Sue Kevane, Barry Cullivan, Sarah Power, Nick Doran, Peter Leamy, Kelly Kelly, Aoife Moran, Conor O'Connor, Mairead McDonnell, Aoife Boyce, Roseanne Sefroun, Faiza Hussain, Rabia Murray, Patrick Malara, Anna Molloy, Brenda O’Halloran, Meadbh Cunningham, Emer Lambert, Jack Cotter, Aoife Marsh, Brian Sheehan, Gerard Muldoon, Eavan Woo, James Gaine, Sean Morley, Deirdre AlGahtani, Farjah H Almaghlouth, Ibrahim Ata, Sondus Alkhathlan, Fai Khalil, Najma Hussein, Israa Mohamed Bashir, Mohammed BaHammam, Ahmed S Alsultan, Abdulrahman Alkofide, Hadeel Alhawassi, Tariq M Alqahtani, Abdulhadi M. Zayed, Emad K. AlSughayir, Ammar Abuzied, Yacoub AlZahrani, Hazzaa Al-Otaibi, Jawaher Alothaimeen, Haya Alzannan, Noura Al Homssi, Amer Abid, Haisam Jones, Stephanie Broaddrick, Shannon Jain, Neha King, Roz Jindal, Mohit Sanfilippo, Kristen Nieters, Patty Hammad, Muhammad Benny, Aleeswa Francis Hamdan, Tariq A. Elobaid, Suhaib Kamal Ahmed Khafagi, Ibrahim Ahmed, Saima Saeed AlEssaie, AbduleRehman AlAlawi, Shamma Bashir, Khloud Al Suwaidi, Aysha Abdulla Salem Ahmed, Hiba Ibrahim Khogali Ismail, Mohamed Milad El Faki, El Mutasim Ahmed Charles, Mercy Dang, Alice Lakhanpal, Gurpreet Lee, Dominic Ray, Prachi Naydenova, Maria Wysocki, Kosma Jiwajee, Aziz Wendling, Greg Boyle, Rebekah Cornell, Elaine Mukaz, Debora Kamin |
author_facet | Sholzberg, Michelle Tang, Grace H Rahhal, Hassan AlHamzah, Musaad Kreuziger, Lisa Baumann Áinle, Fionnuala Ní Alomran, Faris Alayed, Khalid Alsheef, Mohammed AlSumait, Fahad Pompilio, Carlos Eduardo Sperlich, Catherine Tangri, Sabrena Tang, Terence Jaksa, Peter Suryanarayan, Deepa Almarshoodi, Mozah Castellucci, Lana A James, Paula D Lillicrap, David Carrier, Marc Beckett, Andrew Colovos, Christos Jayakar, Jai Arsenault, Marie-Pier Wu, Cynthia Doyon, Karine Andreou, E Roseann Dounaevskaia, Vera Tseng, Eric K Lim, Gloria Fralick, Michael Middeldorp, Saskia Lee, Agnes Y Y Zuo, Fei da Costa, Bruno R Thorpe, Kevin E Negri, Elnara Márcia Cushman, Mary Jüni, Peter Laupacis, Andreas Lin, Yulia Day, Andrew Rochwerg, Bram Abdulrehman, Jameel Gergi, Mansour Kondo, Rodrigo Hidd Piloto, Bruna Mamprim de Abreu Pereira, Guilherme Valente, Fernando Salvetti Agreda, Ariel Fernando Villarroel Munoz Torres, Pablo Andres Moraes, Maíra Oliveira de Lucena Moreira, Claudia Neto, Fernando Galassi Stocco Baptista, Fabíola Vieira Duarte Moreira, Joanne Alves Ferreira, Augusto Séttemo Frudit, Paula Martinez, Gabriel Souza, Heraldo Possolo Neto, Rodrigo Antônio Brandão d'Amico, Elbio Antonio Padrão, Eduardo Messias Hirano Sarin da Mota e Albuquerque, Fernando Zangrossi, Giovanna Villela Kanasiro, Alberto Kendy Cincoto, Alissom Vitti de Souza Reis, Hugo Arias da Silva, Vitor Miyashiro Bellintani, Arthur Petrillo dos Santos Pereira, Vivian de Oliveira, Yohan Washington Carvalho, Bárbara Justo de Souza Novaes, Mariana Silveira, Henrique Brito de Avelar, Gabriel César Alves Mota, Lara Bonanni Caciola, Karina Marim, Matheus de Arêa Leão Freire Monsalvarga, Tales Cabral Blanco Santos, Alexandre Salgado Haydar, Ahmed Saraiva, Gabriella Seixas Sampaio da Costa Ribeiro, Sabrina Correa Meirelles Marchini, Julio Flavio de Alencar, Julio Cesar Garcia de Seixas Santos, Ana Catharina Millette, Caroline Lebeau, Mathieu Devaux, Céline Boutin, Mélina Nguyen, Trung Nghia Srour, Line de Angelis, Flavia Fugulin, Mariane Binnie, Alexandra Bejaimal, Shayna A.D. Binding, Andrew Marticorena, Rosa M. Ginocchio, Galo Kaplovitch, Eric Rymaszewski, Klaudia Raissi, Afsaneh Falappa, Marcelo Ernst, Blair Ali, Amna Romano, Martin Khurram, Mobina Kim, Christie Kapur, Ajay Edwards, Michelle Swarup, Vidushi Camilotti, Bruna Jani, Jiten Carter, Jeff Gillrie, Mark R. Sidhu, Davinder Robinson, Traci Stutely, Krystina Watpool, Irene Porteous, Rebecca Jao, Kevin Boudreault-Pedneault, Jean-Samuel Kandel, Christopher Taylor, Maureen T. Choo, Wei En Enoch Parsons, Laura Dowbenka, Ann Ramonas, Gitana Nikitin, Sergey Patterson, Jeffery Hnatiuk, Mark Tapardel, Anca Lapner, Sarah Takach Carpenter, Thirza Rackel, Lori Cairns, Rebecca Pinder, Jessica Anglin, Peter McPherson, Catherine Chiverton, Liselle Barbosa, David Loukiantchenko, Shany Shamiss, Yana Tassy, Danaë Shivakumar, Sudeep Keating, Mary-Margaret Pleasance, Sue Kevane, Barry Cullivan, Sarah Power, Nick Doran, Peter Leamy, Kelly Kelly, Aoife Moran, Conor O'Connor, Mairead McDonnell, Aoife Boyce, Roseanne Sefroun, Faiza Hussain, Rabia Murray, Patrick Malara, Anna Molloy, Brenda O’Halloran, Meadbh Cunningham, Emer Lambert, Jack Cotter, Aoife Marsh, Brian Sheehan, Gerard Muldoon, Eavan Woo, James Gaine, Sean Morley, Deirdre AlGahtani, Farjah H Almaghlouth, Ibrahim Ata, Sondus Alkhathlan, Fai Khalil, Najma Hussein, Israa Mohamed Bashir, Mohammed BaHammam, Ahmed S Alsultan, Abdulrahman Alkofide, Hadeel Alhawassi, Tariq M Alqahtani, Abdulhadi M. Zayed, Emad K. AlSughayir, Ammar Abuzied, Yacoub AlZahrani, Hazzaa Al-Otaibi, Jawaher Alothaimeen, Haya Alzannan, Noura Al Homssi, Amer Abid, Haisam Jones, Stephanie Broaddrick, Shannon Jain, Neha King, Roz Jindal, Mohit Sanfilippo, Kristen Nieters, Patty Hammad, Muhammad Benny, Aleeswa Francis Hamdan, Tariq A. Elobaid, Suhaib Kamal Ahmed Khafagi, Ibrahim Ahmed, Saima Saeed AlEssaie, AbduleRehman AlAlawi, Shamma Bashir, Khloud Al Suwaidi, Aysha Abdulla Salem Ahmed, Hiba Ibrahim Khogali Ismail, Mohamed Milad El Faki, El Mutasim Ahmed Charles, Mercy Dang, Alice Lakhanpal, Gurpreet Lee, Dominic Ray, Prachi Naydenova, Maria Wysocki, Kosma Jiwajee, Aziz Wendling, Greg Boyle, Rebekah Cornell, Elaine Mukaz, Debora Kamin |
author_sort | Sholzberg, Michelle |
collection | PubMed |
description | OBJECTIVE: To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN: Randomised controlled, adaptive, open label clinical trial. SETTING: 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, United Arab Emirates, and US. PARTICIPANTS: 465 adults admitted to hospital wards with covid-19 and increased D-dimer levels were recruited between 29 May 2020 and 12 April 2021 and were randomly assigned to therapeutic dose heparin (n=228) or prophylactic dose heparin (n=237). INTERVENTIONS: Therapeutic dose or prophylactic dose heparin (low molecular weight or unfractionated heparin), to be continued until hospital discharge, day 28, or death. MAIN OUTCOME MEASURES: The primary outcome was a composite of death, invasive mechanical ventilation, non-invasive mechanical ventilation, or admission to an intensive care unit, assessed up to 28 days. The secondary outcomes included all cause death, the composite of all cause death or any mechanical ventilation, and venous thromboembolism. Safety outcomes included major bleeding. Outcomes were blindly adjudicated. RESULTS: The mean age of participants was 60 years; 264 (56.8%) were men and the mean body mass index was 30.3 kg/m(2). At 28 days, the primary composite outcome had occurred in 37/228 patients (16.2%) assigned to therapeutic heparin and 52/237 (21.9%) assigned to prophylactic heparin (odds ratio 0.69, 95% confidence interval 0.43 to 1.10; P=0.12). Deaths occurred in four patients (1.8%) assigned to therapeutic heparin and 18 patients (7.6%) assigned to prophylactic heparin (0.22, 0.07 to 0.65; P=0.006). The composite of all cause death or any mechanical ventilation occurred in 23 patients (10.1%) assigned to therapeutic heparin and 38 (16.0%) assigned to prophylactic heparin (0.59, 0.34 to 1.02; P=0.06). Venous thromboembolism occurred in two patients (0.9%) assigned to therapeutic heparin and six (2.5%) assigned to prophylactic heparin (0.34, 0.07 to 1.71; P=0.19). Major bleeding occurred in two patients (0.9%) assigned to therapeutic heparin and four (1.7%) assigned to prophylactic heparin (0.52, 0.09 to 2.85; P=0.69). CONCLUSIONS: In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital wards, therapeutic heparin was not significantly associated with a reduction in the primary outcome but the odds of death at 28 days was decreased. The risk of major bleeding appeared low in this trial. TRIAL REGISTRATION: ClinicalTrials.gov NCT04362085. |
format | Online Article Text |
id | pubmed-8515466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85154662021-10-19 Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial Sholzberg, Michelle Tang, Grace H Rahhal, Hassan AlHamzah, Musaad Kreuziger, Lisa Baumann Áinle, Fionnuala Ní Alomran, Faris Alayed, Khalid Alsheef, Mohammed AlSumait, Fahad Pompilio, Carlos Eduardo Sperlich, Catherine Tangri, Sabrena Tang, Terence Jaksa, Peter Suryanarayan, Deepa Almarshoodi, Mozah Castellucci, Lana A James, Paula D Lillicrap, David Carrier, Marc Beckett, Andrew Colovos, Christos Jayakar, Jai Arsenault, Marie-Pier Wu, Cynthia Doyon, Karine Andreou, E Roseann Dounaevskaia, Vera Tseng, Eric K Lim, Gloria Fralick, Michael Middeldorp, Saskia Lee, Agnes Y Y Zuo, Fei da Costa, Bruno R Thorpe, Kevin E Negri, Elnara Márcia Cushman, Mary Jüni, Peter Laupacis, Andreas Lin, Yulia Day, Andrew Rochwerg, Bram Abdulrehman, Jameel Gergi, Mansour Kondo, Rodrigo Hidd Piloto, Bruna Mamprim de Abreu Pereira, Guilherme Valente, Fernando Salvetti Agreda, Ariel Fernando Villarroel Munoz Torres, Pablo Andres Moraes, Maíra Oliveira de Lucena Moreira, Claudia Neto, Fernando Galassi Stocco Baptista, Fabíola Vieira Duarte Moreira, Joanne Alves Ferreira, Augusto Séttemo Frudit, Paula Martinez, Gabriel Souza, Heraldo Possolo Neto, Rodrigo Antônio Brandão d'Amico, Elbio Antonio Padrão, Eduardo Messias Hirano Sarin da Mota e Albuquerque, Fernando Zangrossi, Giovanna Villela Kanasiro, Alberto Kendy Cincoto, Alissom Vitti de Souza Reis, Hugo Arias da Silva, Vitor Miyashiro Bellintani, Arthur Petrillo dos Santos Pereira, Vivian de Oliveira, Yohan Washington Carvalho, Bárbara Justo de Souza Novaes, Mariana Silveira, Henrique Brito de Avelar, Gabriel César Alves Mota, Lara Bonanni Caciola, Karina Marim, Matheus de Arêa Leão Freire Monsalvarga, Tales Cabral Blanco Santos, Alexandre Salgado Haydar, Ahmed Saraiva, Gabriella Seixas Sampaio da Costa Ribeiro, Sabrina Correa Meirelles Marchini, Julio Flavio de Alencar, Julio Cesar Garcia de Seixas Santos, Ana Catharina Millette, Caroline Lebeau, Mathieu Devaux, Céline Boutin, Mélina Nguyen, Trung Nghia Srour, Line de Angelis, Flavia Fugulin, Mariane Binnie, Alexandra Bejaimal, Shayna A.D. Binding, Andrew Marticorena, Rosa M. Ginocchio, Galo Kaplovitch, Eric Rymaszewski, Klaudia Raissi, Afsaneh Falappa, Marcelo Ernst, Blair Ali, Amna Romano, Martin Khurram, Mobina Kim, Christie Kapur, Ajay Edwards, Michelle Swarup, Vidushi Camilotti, Bruna Jani, Jiten Carter, Jeff Gillrie, Mark R. Sidhu, Davinder Robinson, Traci Stutely, Krystina Watpool, Irene Porteous, Rebecca Jao, Kevin Boudreault-Pedneault, Jean-Samuel Kandel, Christopher Taylor, Maureen T. Choo, Wei En Enoch Parsons, Laura Dowbenka, Ann Ramonas, Gitana Nikitin, Sergey Patterson, Jeffery Hnatiuk, Mark Tapardel, Anca Lapner, Sarah Takach Carpenter, Thirza Rackel, Lori Cairns, Rebecca Pinder, Jessica Anglin, Peter McPherson, Catherine Chiverton, Liselle Barbosa, David Loukiantchenko, Shany Shamiss, Yana Tassy, Danaë Shivakumar, Sudeep Keating, Mary-Margaret Pleasance, Sue Kevane, Barry Cullivan, Sarah Power, Nick Doran, Peter Leamy, Kelly Kelly, Aoife Moran, Conor O'Connor, Mairead McDonnell, Aoife Boyce, Roseanne Sefroun, Faiza Hussain, Rabia Murray, Patrick Malara, Anna Molloy, Brenda O’Halloran, Meadbh Cunningham, Emer Lambert, Jack Cotter, Aoife Marsh, Brian Sheehan, Gerard Muldoon, Eavan Woo, James Gaine, Sean Morley, Deirdre AlGahtani, Farjah H Almaghlouth, Ibrahim Ata, Sondus Alkhathlan, Fai Khalil, Najma Hussein, Israa Mohamed Bashir, Mohammed BaHammam, Ahmed S Alsultan, Abdulrahman Alkofide, Hadeel Alhawassi, Tariq M Alqahtani, Abdulhadi M. Zayed, Emad K. AlSughayir, Ammar Abuzied, Yacoub AlZahrani, Hazzaa Al-Otaibi, Jawaher Alothaimeen, Haya Alzannan, Noura Al Homssi, Amer Abid, Haisam Jones, Stephanie Broaddrick, Shannon Jain, Neha King, Roz Jindal, Mohit Sanfilippo, Kristen Nieters, Patty Hammad, Muhammad Benny, Aleeswa Francis Hamdan, Tariq A. Elobaid, Suhaib Kamal Ahmed Khafagi, Ibrahim Ahmed, Saima Saeed AlEssaie, AbduleRehman AlAlawi, Shamma Bashir, Khloud Al Suwaidi, Aysha Abdulla Salem Ahmed, Hiba Ibrahim Khogali Ismail, Mohamed Milad El Faki, El Mutasim Ahmed Charles, Mercy Dang, Alice Lakhanpal, Gurpreet Lee, Dominic Ray, Prachi Naydenova, Maria Wysocki, Kosma Jiwajee, Aziz Wendling, Greg Boyle, Rebekah Cornell, Elaine Mukaz, Debora Kamin BMJ Research OBJECTIVE: To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN: Randomised controlled, adaptive, open label clinical trial. SETTING: 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, United Arab Emirates, and US. PARTICIPANTS: 465 adults admitted to hospital wards with covid-19 and increased D-dimer levels were recruited between 29 May 2020 and 12 April 2021 and were randomly assigned to therapeutic dose heparin (n=228) or prophylactic dose heparin (n=237). INTERVENTIONS: Therapeutic dose or prophylactic dose heparin (low molecular weight or unfractionated heparin), to be continued until hospital discharge, day 28, or death. MAIN OUTCOME MEASURES: The primary outcome was a composite of death, invasive mechanical ventilation, non-invasive mechanical ventilation, or admission to an intensive care unit, assessed up to 28 days. The secondary outcomes included all cause death, the composite of all cause death or any mechanical ventilation, and venous thromboembolism. Safety outcomes included major bleeding. Outcomes were blindly adjudicated. RESULTS: The mean age of participants was 60 years; 264 (56.8%) were men and the mean body mass index was 30.3 kg/m(2). At 28 days, the primary composite outcome had occurred in 37/228 patients (16.2%) assigned to therapeutic heparin and 52/237 (21.9%) assigned to prophylactic heparin (odds ratio 0.69, 95% confidence interval 0.43 to 1.10; P=0.12). Deaths occurred in four patients (1.8%) assigned to therapeutic heparin and 18 patients (7.6%) assigned to prophylactic heparin (0.22, 0.07 to 0.65; P=0.006). The composite of all cause death or any mechanical ventilation occurred in 23 patients (10.1%) assigned to therapeutic heparin and 38 (16.0%) assigned to prophylactic heparin (0.59, 0.34 to 1.02; P=0.06). Venous thromboembolism occurred in two patients (0.9%) assigned to therapeutic heparin and six (2.5%) assigned to prophylactic heparin (0.34, 0.07 to 1.71; P=0.19). Major bleeding occurred in two patients (0.9%) assigned to therapeutic heparin and four (1.7%) assigned to prophylactic heparin (0.52, 0.09 to 2.85; P=0.69). CONCLUSIONS: In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital wards, therapeutic heparin was not significantly associated with a reduction in the primary outcome but the odds of death at 28 days was decreased. The risk of major bleeding appeared low in this trial. TRIAL REGISTRATION: ClinicalTrials.gov NCT04362085. BMJ Publishing Group Ltd. 2021-10-14 /pmc/articles/PMC8515466/ /pubmed/34649864 http://dx.doi.org/10.1136/bmj.n2400 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Research Sholzberg, Michelle Tang, Grace H Rahhal, Hassan AlHamzah, Musaad Kreuziger, Lisa Baumann Áinle, Fionnuala Ní Alomran, Faris Alayed, Khalid Alsheef, Mohammed AlSumait, Fahad Pompilio, Carlos Eduardo Sperlich, Catherine Tangri, Sabrena Tang, Terence Jaksa, Peter Suryanarayan, Deepa Almarshoodi, Mozah Castellucci, Lana A James, Paula D Lillicrap, David Carrier, Marc Beckett, Andrew Colovos, Christos Jayakar, Jai Arsenault, Marie-Pier Wu, Cynthia Doyon, Karine Andreou, E Roseann Dounaevskaia, Vera Tseng, Eric K Lim, Gloria Fralick, Michael Middeldorp, Saskia Lee, Agnes Y Y Zuo, Fei da Costa, Bruno R Thorpe, Kevin E Negri, Elnara Márcia Cushman, Mary Jüni, Peter Laupacis, Andreas Lin, Yulia Day, Andrew Rochwerg, Bram Abdulrehman, Jameel Gergi, Mansour Kondo, Rodrigo Hidd Piloto, Bruna Mamprim de Abreu Pereira, Guilherme Valente, Fernando Salvetti Agreda, Ariel Fernando Villarroel Munoz Torres, Pablo Andres Moraes, Maíra Oliveira de Lucena Moreira, Claudia Neto, Fernando Galassi Stocco Baptista, Fabíola Vieira Duarte Moreira, Joanne Alves Ferreira, Augusto Séttemo Frudit, Paula Martinez, Gabriel Souza, Heraldo Possolo Neto, Rodrigo Antônio Brandão d'Amico, Elbio Antonio Padrão, Eduardo Messias Hirano Sarin da Mota e Albuquerque, Fernando Zangrossi, Giovanna Villela Kanasiro, Alberto Kendy Cincoto, Alissom Vitti de Souza Reis, Hugo Arias da Silva, Vitor Miyashiro Bellintani, Arthur Petrillo dos Santos Pereira, Vivian de Oliveira, Yohan Washington Carvalho, Bárbara Justo de Souza Novaes, Mariana Silveira, Henrique Brito de Avelar, Gabriel César Alves Mota, Lara Bonanni Caciola, Karina Marim, Matheus de Arêa Leão Freire Monsalvarga, Tales Cabral Blanco Santos, Alexandre Salgado Haydar, Ahmed Saraiva, Gabriella Seixas Sampaio da Costa Ribeiro, Sabrina Correa Meirelles Marchini, Julio Flavio de Alencar, Julio Cesar Garcia de Seixas Santos, Ana Catharina Millette, Caroline Lebeau, Mathieu Devaux, Céline Boutin, Mélina Nguyen, Trung Nghia Srour, Line de Angelis, Flavia Fugulin, Mariane Binnie, Alexandra Bejaimal, Shayna A.D. Binding, Andrew Marticorena, Rosa M. Ginocchio, Galo Kaplovitch, Eric Rymaszewski, Klaudia Raissi, Afsaneh Falappa, Marcelo Ernst, Blair Ali, Amna Romano, Martin Khurram, Mobina Kim, Christie Kapur, Ajay Edwards, Michelle Swarup, Vidushi Camilotti, Bruna Jani, Jiten Carter, Jeff Gillrie, Mark R. Sidhu, Davinder Robinson, Traci Stutely, Krystina Watpool, Irene Porteous, Rebecca Jao, Kevin Boudreault-Pedneault, Jean-Samuel Kandel, Christopher Taylor, Maureen T. Choo, Wei En Enoch Parsons, Laura Dowbenka, Ann Ramonas, Gitana Nikitin, Sergey Patterson, Jeffery Hnatiuk, Mark Tapardel, Anca Lapner, Sarah Takach Carpenter, Thirza Rackel, Lori Cairns, Rebecca Pinder, Jessica Anglin, Peter McPherson, Catherine Chiverton, Liselle Barbosa, David Loukiantchenko, Shany Shamiss, Yana Tassy, Danaë Shivakumar, Sudeep Keating, Mary-Margaret Pleasance, Sue Kevane, Barry Cullivan, Sarah Power, Nick Doran, Peter Leamy, Kelly Kelly, Aoife Moran, Conor O'Connor, Mairead McDonnell, Aoife Boyce, Roseanne Sefroun, Faiza Hussain, Rabia Murray, Patrick Malara, Anna Molloy, Brenda O’Halloran, Meadbh Cunningham, Emer Lambert, Jack Cotter, Aoife Marsh, Brian Sheehan, Gerard Muldoon, Eavan Woo, James Gaine, Sean Morley, Deirdre AlGahtani, Farjah H Almaghlouth, Ibrahim Ata, Sondus Alkhathlan, Fai Khalil, Najma Hussein, Israa Mohamed Bashir, Mohammed BaHammam, Ahmed S Alsultan, Abdulrahman Alkofide, Hadeel Alhawassi, Tariq M Alqahtani, Abdulhadi M. Zayed, Emad K. AlSughayir, Ammar Abuzied, Yacoub AlZahrani, Hazzaa Al-Otaibi, Jawaher Alothaimeen, Haya Alzannan, Noura Al Homssi, Amer Abid, Haisam Jones, Stephanie Broaddrick, Shannon Jain, Neha King, Roz Jindal, Mohit Sanfilippo, Kristen Nieters, Patty Hammad, Muhammad Benny, Aleeswa Francis Hamdan, Tariq A. Elobaid, Suhaib Kamal Ahmed Khafagi, Ibrahim Ahmed, Saima Saeed AlEssaie, AbduleRehman AlAlawi, Shamma Bashir, Khloud Al Suwaidi, Aysha Abdulla Salem Ahmed, Hiba Ibrahim Khogali Ismail, Mohamed Milad El Faki, El Mutasim Ahmed Charles, Mercy Dang, Alice Lakhanpal, Gurpreet Lee, Dominic Ray, Prachi Naydenova, Maria Wysocki, Kosma Jiwajee, Aziz Wendling, Greg Boyle, Rebekah Cornell, Elaine Mukaz, Debora Kamin Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial |
title | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial |
title_full | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial |
title_fullStr | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial |
title_full_unstemmed | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial |
title_short | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial |
title_sort | effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: rapid randomised clinical trial |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515466/ https://www.ncbi.nlm.nih.gov/pubmed/34649864 http://dx.doi.org/10.1136/bmj.n2400 |
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effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT pleasancesue effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT kevanebarry effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT cullivansarah effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT powernick effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT doranpeter effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT leamykelly effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT kellyaoife effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT moranconor effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT oconnormairead effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT mcdonnellaoife effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT boyceroseanne effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT sefrounfaiza effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT hussainrabia effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT murraypatrick effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT malaraanna effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT molloybrenda effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT ohalloranmeadbh effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT cunninghamemer effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT lambertjack effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT cotteraoife effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT marshbrian effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT sheehangerard effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT muldooneavan effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT woojames effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT gainesean effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT morleydeirdre effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT algahtanifarjahh effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT almaghlouthibrahim effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT atasondus effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alkhathlanfai effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT khalilnajma effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT husseinisraamohamed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT bashirmohammed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT bahammamahmeds effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alsultanabdulrahman effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alkofidehadeel effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alhawassitariqm effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alqahtaniabdulhadim effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT zayedemadk effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alsughayirammar effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT abuziedyacoub effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alzahranihazzaa effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alotaibijawaher effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alothaimeenhaya effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alzannannoura effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alhomssiamer effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT abidhaisam effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT jonesstephanie effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT broaddrickshannon effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT jainneha effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT kingroz effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT jindalmohit effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT sanfilippokristen effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT nieterspatty effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT hammadmuhammad effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT bennyaleeswafrancis effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT hamdantariqa effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT elobaidsuhaibkamalahmed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT khafagiibrahim effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT ahmedsaimasaeed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alessaieabdulerehman effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alalawishamma effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT bashirkhloud effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT alsuwaidiayshaabdullasalem effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT ahmedhibaibrahimkhogali effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT ismailmohamedmilad effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT elfakielmutasimahmed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT charlesmercy effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT dangalice effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT lakhanpalgurpreet effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT leedominic effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT rayprachi effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT naydenovamaria effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT wysockikosma effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT jiwajeeaziz effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT wendlinggreg effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT boylerebekah effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT cornellelaine effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial AT mukazdeborakamin effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial |