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Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial

OBJECTIVE: To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN: Randomised controlled, adaptive, open label clinical trial. SETTING: 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, Uni...

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Autores principales: Sholzberg, Michelle, Tang, Grace H, Rahhal, Hassan, AlHamzah, Musaad, Kreuziger, Lisa Baumann, Áinle, Fionnuala Ní, Alomran, Faris, Alayed, Khalid, Alsheef, Mohammed, AlSumait, Fahad, Pompilio, Carlos Eduardo, Sperlich, Catherine, Tangri, Sabrena, Tang, Terence, Jaksa, Peter, Suryanarayan, Deepa, Almarshoodi, Mozah, Castellucci, Lana A, James, Paula D, Lillicrap, David, Carrier, Marc, Beckett, Andrew, Colovos, Christos, Jayakar, Jai, Arsenault, Marie-Pier, Wu, Cynthia, Doyon, Karine, Andreou, E Roseann, Dounaevskaia, Vera, Tseng, Eric K, Lim, Gloria, Fralick, Michael, Middeldorp, Saskia, Lee, Agnes Y Y, Zuo, Fei, da Costa, Bruno R, Thorpe, Kevin E, Negri, Elnara Márcia, Cushman, Mary, Jüni, Peter, Laupacis, Andreas, Lin, Yulia, Day, Andrew, Rochwerg, Bram, Abdulrehman, Jameel, Gergi, Mansour, Kondo, Rodrigo Hidd, Piloto, Bruna Mamprim, de Abreu Pereira, Guilherme, Valente, Fernando Salvetti, Agreda, Ariel Fernando Villarroel, Munoz Torres, Pablo Andres, Moraes, Maíra Oliveira, de Lucena Moreira, Claudia, Neto, Fernando Galassi Stocco, Baptista, Fabíola Vieira Duarte, Moreira, Joanne Alves, Ferreira, Augusto Séttemo, Frudit, Paula, Martinez, Gabriel, Souza, Heraldo Possolo, Neto, Rodrigo Antônio Brandão, d'Amico, Elbio Antonio, Padrão, Eduardo Messias Hirano, Sarin da Mota e Albuquerque, Fernando, Zangrossi, Giovanna Villela, Kanasiro, Alberto Kendy, Cincoto, Alissom Vitti, de Souza Reis, Hugo, Arias da Silva, Vitor Miyashiro, Bellintani, Arthur Petrillo, dos Santos Pereira, Vivian, de Oliveira, Yohan Washington, Carvalho, Bárbara Justo, de Souza Novaes, Mariana, Silveira, Henrique Brito, de Avelar, Gabriel César Alves, Mota, Lara Bonanni, Caciola, Karina, Marim, Matheus de Arêa Leão Freire, Monsalvarga, Tales Cabral, Blanco Santos, Alexandre Salgado, Haydar, Ahmed, Saraiva, Gabriella Seixas Sampaio, da Costa Ribeiro, Sabrina Correa, Meirelles Marchini, Julio Flavio, de Alencar, Julio Cesar Garcia, de Seixas Santos, Ana Catharina, Millette, Caroline, Lebeau, Mathieu, Devaux, Céline, Boutin, Mélina, Nguyen, Trung Nghia, Srour, Line, de Angelis, Flavia, Fugulin, Mariane, Binnie, Alexandra, Bejaimal, Shayna A.D., Binding, Andrew, Marticorena, Rosa M., Ginocchio, Galo, Kaplovitch, Eric, Rymaszewski, Klaudia, Raissi, Afsaneh, Falappa, Marcelo, Ernst, Blair, Ali, Amna, Romano, Martin, Khurram, Mobina, Kim, Christie, Kapur, Ajay, Edwards, Michelle, Swarup, Vidushi, Camilotti, Bruna, Jani, Jiten, Carter, Jeff, Gillrie, Mark R., Sidhu, Davinder, Robinson, Traci, Stutely, Krystina, Watpool, Irene, Porteous, Rebecca, Jao, Kevin, Boudreault-Pedneault, Jean-Samuel, Kandel, Christopher, Taylor, Maureen T., Choo, Wei En Enoch, Parsons, Laura, Dowbenka, Ann, Ramonas, Gitana, Nikitin, Sergey, Patterson, Jeffery, Hnatiuk, Mark, Tapardel, Anca, Lapner, Sarah Takach, Carpenter, Thirza, Rackel, Lori, Cairns, Rebecca, Pinder, Jessica, Anglin, Peter, McPherson, Catherine, Chiverton, Liselle, Barbosa, David, Loukiantchenko, Shany, Shamiss, Yana, Tassy, Danaë, Shivakumar, Sudeep, Keating, Mary-Margaret, Pleasance, Sue, Kevane, Barry, Cullivan, Sarah, Power, Nick, Doran, Peter, Leamy, Kelly, Kelly, Aoife, Moran, Conor, O'Connor, Mairead, McDonnell, Aoife, Boyce, Roseanne, Sefroun, Faiza, Hussain, Rabia, Murray, Patrick, Malara, Anna, Molloy, Brenda, O’Halloran, Meadbh, Cunningham, Emer, Lambert, Jack, Cotter, Aoife, Marsh, Brian, Sheehan, Gerard, Muldoon, Eavan, Woo, James, Gaine, Sean, Morley, Deirdre, AlGahtani, Farjah H, Almaghlouth, Ibrahim, Ata, Sondus, Alkhathlan, Fai, Khalil, Najma, Hussein, Israa Mohamed, Bashir, Mohammed, BaHammam, Ahmed S, Alsultan, Abdulrahman, Alkofide, Hadeel, Alhawassi, Tariq M, Alqahtani, Abdulhadi M., Zayed, Emad K., AlSughayir, Ammar, Abuzied, Yacoub, AlZahrani, Hazzaa, Al-Otaibi, Jawaher, Alothaimeen, Haya, Alzannan, Noura, Al Homssi, Amer, Abid, Haisam, Jones, Stephanie, Broaddrick, Shannon, Jain, Neha, King, Roz, Jindal, Mohit, Sanfilippo, Kristen, Nieters, Patty, Hammad, Muhammad, Benny, Aleeswa Francis, Hamdan, Tariq A., Elobaid, Suhaib Kamal Ahmed, Khafagi, Ibrahim, Ahmed, Saima Saeed, AlEssaie, AbduleRehman, AlAlawi, Shamma, Bashir, Khloud, Al Suwaidi, Aysha Abdulla Salem, Ahmed, Hiba Ibrahim Khogali, Ismail, Mohamed Milad, El Faki, El Mutasim Ahmed, Charles, Mercy, Dang, Alice, Lakhanpal, Gurpreet, Lee, Dominic, Ray, Prachi, Naydenova, Maria, Wysocki, Kosma, Jiwajee, Aziz, Wendling, Greg, Boyle, Rebekah, Cornell, Elaine, Mukaz, Debora Kamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515466/
https://www.ncbi.nlm.nih.gov/pubmed/34649864
http://dx.doi.org/10.1136/bmj.n2400
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author Sholzberg, Michelle
Tang, Grace H
Rahhal, Hassan
AlHamzah, Musaad
Kreuziger, Lisa Baumann
Áinle, Fionnuala Ní
Alomran, Faris
Alayed, Khalid
Alsheef, Mohammed
AlSumait, Fahad
Pompilio, Carlos Eduardo
Sperlich, Catherine
Tangri, Sabrena
Tang, Terence
Jaksa, Peter
Suryanarayan, Deepa
Almarshoodi, Mozah
Castellucci, Lana A
James, Paula D
Lillicrap, David
Carrier, Marc
Beckett, Andrew
Colovos, Christos
Jayakar, Jai
Arsenault, Marie-Pier
Wu, Cynthia
Doyon, Karine
Andreou, E Roseann
Dounaevskaia, Vera
Tseng, Eric K
Lim, Gloria
Fralick, Michael
Middeldorp, Saskia
Lee, Agnes Y Y
Zuo, Fei
da Costa, Bruno R
Thorpe, Kevin E
Negri, Elnara Márcia
Cushman, Mary
Jüni, Peter
Laupacis, Andreas
Lin, Yulia
Day, Andrew
Rochwerg, Bram
Abdulrehman, Jameel
Gergi, Mansour
Kondo, Rodrigo Hidd
Piloto, Bruna Mamprim
de Abreu Pereira, Guilherme
Valente, Fernando Salvetti
Agreda, Ariel Fernando Villarroel
Munoz Torres, Pablo Andres
Moraes, Maíra Oliveira
de Lucena Moreira, Claudia
Neto, Fernando Galassi Stocco
Baptista, Fabíola Vieira Duarte
Moreira, Joanne Alves
Ferreira, Augusto Séttemo
Frudit, Paula
Martinez, Gabriel
Souza, Heraldo Possolo
Neto, Rodrigo Antônio Brandão
d'Amico, Elbio Antonio
Padrão, Eduardo Messias Hirano
Sarin da Mota e Albuquerque, Fernando
Zangrossi, Giovanna Villela
Kanasiro, Alberto Kendy
Cincoto, Alissom Vitti
de Souza Reis, Hugo
Arias da Silva, Vitor Miyashiro
Bellintani, Arthur Petrillo
dos Santos Pereira, Vivian
de Oliveira, Yohan Washington
Carvalho, Bárbara Justo
de Souza Novaes, Mariana
Silveira, Henrique Brito
de Avelar, Gabriel César Alves
Mota, Lara Bonanni
Caciola, Karina
Marim, Matheus de Arêa Leão Freire
Monsalvarga, Tales Cabral
Blanco Santos, Alexandre Salgado
Haydar, Ahmed
Saraiva, Gabriella Seixas Sampaio
da Costa Ribeiro, Sabrina Correa
Meirelles Marchini, Julio Flavio
de Alencar, Julio Cesar Garcia
de Seixas Santos, Ana Catharina
Millette, Caroline
Lebeau, Mathieu
Devaux, Céline
Boutin, Mélina
Nguyen, Trung Nghia
Srour, Line
de Angelis, Flavia
Fugulin, Mariane
Binnie, Alexandra
Bejaimal, Shayna A.D.
Binding, Andrew
Marticorena, Rosa M.
Ginocchio, Galo
Kaplovitch, Eric
Rymaszewski, Klaudia
Raissi, Afsaneh
Falappa, Marcelo
Ernst, Blair
Ali, Amna
Romano, Martin
Khurram, Mobina
Kim, Christie
Kapur, Ajay
Edwards, Michelle
Swarup, Vidushi
Camilotti, Bruna
Jani, Jiten
Carter, Jeff
Gillrie, Mark R.
Sidhu, Davinder
Robinson, Traci
Stutely, Krystina
Watpool, Irene
Porteous, Rebecca
Jao, Kevin
Boudreault-Pedneault, Jean-Samuel
Kandel, Christopher
Taylor, Maureen T.
Choo, Wei En Enoch
Parsons, Laura
Dowbenka, Ann
Ramonas, Gitana
Nikitin, Sergey
Patterson, Jeffery
Hnatiuk, Mark
Tapardel, Anca
Lapner, Sarah Takach
Carpenter, Thirza
Rackel, Lori
Cairns, Rebecca
Pinder, Jessica
Anglin, Peter
McPherson, Catherine
Chiverton, Liselle
Barbosa, David
Loukiantchenko, Shany
Shamiss, Yana
Tassy, Danaë
Shivakumar, Sudeep
Keating, Mary-Margaret
Pleasance, Sue
Kevane, Barry
Cullivan, Sarah
Power, Nick
Doran, Peter
Leamy, Kelly
Kelly, Aoife
Moran, Conor
O'Connor, Mairead
McDonnell, Aoife
Boyce, Roseanne
Sefroun, Faiza
Hussain, Rabia
Murray, Patrick
Malara, Anna
Molloy, Brenda
O’Halloran, Meadbh
Cunningham, Emer
Lambert, Jack
Cotter, Aoife
Marsh, Brian
Sheehan, Gerard
Muldoon, Eavan
Woo, James
Gaine, Sean
Morley, Deirdre
AlGahtani, Farjah H
Almaghlouth, Ibrahim
Ata, Sondus
Alkhathlan, Fai
Khalil, Najma
Hussein, Israa Mohamed
Bashir, Mohammed
BaHammam, Ahmed S
Alsultan, Abdulrahman
Alkofide, Hadeel
Alhawassi, Tariq M
Alqahtani, Abdulhadi M.
Zayed, Emad K.
AlSughayir, Ammar
Abuzied, Yacoub
AlZahrani, Hazzaa
Al-Otaibi, Jawaher
Alothaimeen, Haya
Alzannan, Noura
Al Homssi, Amer
Abid, Haisam
Jones, Stephanie
Broaddrick, Shannon
Jain, Neha
King, Roz
Jindal, Mohit
Sanfilippo, Kristen
Nieters, Patty
Hammad, Muhammad
Benny, Aleeswa Francis
Hamdan, Tariq A.
Elobaid, Suhaib Kamal Ahmed
Khafagi, Ibrahim
Ahmed, Saima Saeed
AlEssaie, AbduleRehman
AlAlawi, Shamma
Bashir, Khloud
Al Suwaidi, Aysha Abdulla Salem
Ahmed, Hiba Ibrahim Khogali
Ismail, Mohamed Milad
El Faki, El Mutasim Ahmed
Charles, Mercy
Dang, Alice
Lakhanpal, Gurpreet
Lee, Dominic
Ray, Prachi
Naydenova, Maria
Wysocki, Kosma
Jiwajee, Aziz
Wendling, Greg
Boyle, Rebekah
Cornell, Elaine
Mukaz, Debora Kamin
author_facet Sholzberg, Michelle
Tang, Grace H
Rahhal, Hassan
AlHamzah, Musaad
Kreuziger, Lisa Baumann
Áinle, Fionnuala Ní
Alomran, Faris
Alayed, Khalid
Alsheef, Mohammed
AlSumait, Fahad
Pompilio, Carlos Eduardo
Sperlich, Catherine
Tangri, Sabrena
Tang, Terence
Jaksa, Peter
Suryanarayan, Deepa
Almarshoodi, Mozah
Castellucci, Lana A
James, Paula D
Lillicrap, David
Carrier, Marc
Beckett, Andrew
Colovos, Christos
Jayakar, Jai
Arsenault, Marie-Pier
Wu, Cynthia
Doyon, Karine
Andreou, E Roseann
Dounaevskaia, Vera
Tseng, Eric K
Lim, Gloria
Fralick, Michael
Middeldorp, Saskia
Lee, Agnes Y Y
Zuo, Fei
da Costa, Bruno R
Thorpe, Kevin E
Negri, Elnara Márcia
Cushman, Mary
Jüni, Peter
Laupacis, Andreas
Lin, Yulia
Day, Andrew
Rochwerg, Bram
Abdulrehman, Jameel
Gergi, Mansour
Kondo, Rodrigo Hidd
Piloto, Bruna Mamprim
de Abreu Pereira, Guilherme
Valente, Fernando Salvetti
Agreda, Ariel Fernando Villarroel
Munoz Torres, Pablo Andres
Moraes, Maíra Oliveira
de Lucena Moreira, Claudia
Neto, Fernando Galassi Stocco
Baptista, Fabíola Vieira Duarte
Moreira, Joanne Alves
Ferreira, Augusto Séttemo
Frudit, Paula
Martinez, Gabriel
Souza, Heraldo Possolo
Neto, Rodrigo Antônio Brandão
d'Amico, Elbio Antonio
Padrão, Eduardo Messias Hirano
Sarin da Mota e Albuquerque, Fernando
Zangrossi, Giovanna Villela
Kanasiro, Alberto Kendy
Cincoto, Alissom Vitti
de Souza Reis, Hugo
Arias da Silva, Vitor Miyashiro
Bellintani, Arthur Petrillo
dos Santos Pereira, Vivian
de Oliveira, Yohan Washington
Carvalho, Bárbara Justo
de Souza Novaes, Mariana
Silveira, Henrique Brito
de Avelar, Gabriel César Alves
Mota, Lara Bonanni
Caciola, Karina
Marim, Matheus de Arêa Leão Freire
Monsalvarga, Tales Cabral
Blanco Santos, Alexandre Salgado
Haydar, Ahmed
Saraiva, Gabriella Seixas Sampaio
da Costa Ribeiro, Sabrina Correa
Meirelles Marchini, Julio Flavio
de Alencar, Julio Cesar Garcia
de Seixas Santos, Ana Catharina
Millette, Caroline
Lebeau, Mathieu
Devaux, Céline
Boutin, Mélina
Nguyen, Trung Nghia
Srour, Line
de Angelis, Flavia
Fugulin, Mariane
Binnie, Alexandra
Bejaimal, Shayna A.D.
Binding, Andrew
Marticorena, Rosa M.
Ginocchio, Galo
Kaplovitch, Eric
Rymaszewski, Klaudia
Raissi, Afsaneh
Falappa, Marcelo
Ernst, Blair
Ali, Amna
Romano, Martin
Khurram, Mobina
Kim, Christie
Kapur, Ajay
Edwards, Michelle
Swarup, Vidushi
Camilotti, Bruna
Jani, Jiten
Carter, Jeff
Gillrie, Mark R.
Sidhu, Davinder
Robinson, Traci
Stutely, Krystina
Watpool, Irene
Porteous, Rebecca
Jao, Kevin
Boudreault-Pedneault, Jean-Samuel
Kandel, Christopher
Taylor, Maureen T.
Choo, Wei En Enoch
Parsons, Laura
Dowbenka, Ann
Ramonas, Gitana
Nikitin, Sergey
Patterson, Jeffery
Hnatiuk, Mark
Tapardel, Anca
Lapner, Sarah Takach
Carpenter, Thirza
Rackel, Lori
Cairns, Rebecca
Pinder, Jessica
Anglin, Peter
McPherson, Catherine
Chiverton, Liselle
Barbosa, David
Loukiantchenko, Shany
Shamiss, Yana
Tassy, Danaë
Shivakumar, Sudeep
Keating, Mary-Margaret
Pleasance, Sue
Kevane, Barry
Cullivan, Sarah
Power, Nick
Doran, Peter
Leamy, Kelly
Kelly, Aoife
Moran, Conor
O'Connor, Mairead
McDonnell, Aoife
Boyce, Roseanne
Sefroun, Faiza
Hussain, Rabia
Murray, Patrick
Malara, Anna
Molloy, Brenda
O’Halloran, Meadbh
Cunningham, Emer
Lambert, Jack
Cotter, Aoife
Marsh, Brian
Sheehan, Gerard
Muldoon, Eavan
Woo, James
Gaine, Sean
Morley, Deirdre
AlGahtani, Farjah H
Almaghlouth, Ibrahim
Ata, Sondus
Alkhathlan, Fai
Khalil, Najma
Hussein, Israa Mohamed
Bashir, Mohammed
BaHammam, Ahmed S
Alsultan, Abdulrahman
Alkofide, Hadeel
Alhawassi, Tariq M
Alqahtani, Abdulhadi M.
Zayed, Emad K.
AlSughayir, Ammar
Abuzied, Yacoub
AlZahrani, Hazzaa
Al-Otaibi, Jawaher
Alothaimeen, Haya
Alzannan, Noura
Al Homssi, Amer
Abid, Haisam
Jones, Stephanie
Broaddrick, Shannon
Jain, Neha
King, Roz
Jindal, Mohit
Sanfilippo, Kristen
Nieters, Patty
Hammad, Muhammad
Benny, Aleeswa Francis
Hamdan, Tariq A.
Elobaid, Suhaib Kamal Ahmed
Khafagi, Ibrahim
Ahmed, Saima Saeed
AlEssaie, AbduleRehman
AlAlawi, Shamma
Bashir, Khloud
Al Suwaidi, Aysha Abdulla Salem
Ahmed, Hiba Ibrahim Khogali
Ismail, Mohamed Milad
El Faki, El Mutasim Ahmed
Charles, Mercy
Dang, Alice
Lakhanpal, Gurpreet
Lee, Dominic
Ray, Prachi
Naydenova, Maria
Wysocki, Kosma
Jiwajee, Aziz
Wendling, Greg
Boyle, Rebekah
Cornell, Elaine
Mukaz, Debora Kamin
author_sort Sholzberg, Michelle
collection PubMed
description OBJECTIVE: To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN: Randomised controlled, adaptive, open label clinical trial. SETTING: 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, United Arab Emirates, and US. PARTICIPANTS: 465 adults admitted to hospital wards with covid-19 and increased D-dimer levels were recruited between 29 May 2020 and 12 April 2021 and were randomly assigned to therapeutic dose heparin (n=228) or prophylactic dose heparin (n=237). INTERVENTIONS: Therapeutic dose or prophylactic dose heparin (low molecular weight or unfractionated heparin), to be continued until hospital discharge, day 28, or death. MAIN OUTCOME MEASURES: The primary outcome was a composite of death, invasive mechanical ventilation, non-invasive mechanical ventilation, or admission to an intensive care unit, assessed up to 28 days. The secondary outcomes included all cause death, the composite of all cause death or any mechanical ventilation, and venous thromboembolism. Safety outcomes included major bleeding. Outcomes were blindly adjudicated. RESULTS: The mean age of participants was 60 years; 264 (56.8%) were men and the mean body mass index was 30.3 kg/m(2). At 28 days, the primary composite outcome had occurred in 37/228 patients (16.2%) assigned to therapeutic heparin and 52/237 (21.9%) assigned to prophylactic heparin (odds ratio 0.69, 95% confidence interval 0.43 to 1.10; P=0.12). Deaths occurred in four patients (1.8%) assigned to therapeutic heparin and 18 patients (7.6%) assigned to prophylactic heparin (0.22, 0.07 to 0.65; P=0.006). The composite of all cause death or any mechanical ventilation occurred in 23 patients (10.1%) assigned to therapeutic heparin and 38 (16.0%) assigned to prophylactic heparin (0.59, 0.34 to 1.02; P=0.06). Venous thromboembolism occurred in two patients (0.9%) assigned to therapeutic heparin and six (2.5%) assigned to prophylactic heparin (0.34, 0.07 to 1.71; P=0.19). Major bleeding occurred in two patients (0.9%) assigned to therapeutic heparin and four (1.7%) assigned to prophylactic heparin (0.52, 0.09 to 2.85; P=0.69). CONCLUSIONS: In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital wards, therapeutic heparin was not significantly associated with a reduction in the primary outcome but the odds of death at 28 days was decreased. The risk of major bleeding appeared low in this trial. TRIAL REGISTRATION: ClinicalTrials.gov NCT04362085.
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spelling pubmed-85154662021-10-19 Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial Sholzberg, Michelle Tang, Grace H Rahhal, Hassan AlHamzah, Musaad Kreuziger, Lisa Baumann Áinle, Fionnuala Ní Alomran, Faris Alayed, Khalid Alsheef, Mohammed AlSumait, Fahad Pompilio, Carlos Eduardo Sperlich, Catherine Tangri, Sabrena Tang, Terence Jaksa, Peter Suryanarayan, Deepa Almarshoodi, Mozah Castellucci, Lana A James, Paula D Lillicrap, David Carrier, Marc Beckett, Andrew Colovos, Christos Jayakar, Jai Arsenault, Marie-Pier Wu, Cynthia Doyon, Karine Andreou, E Roseann Dounaevskaia, Vera Tseng, Eric K Lim, Gloria Fralick, Michael Middeldorp, Saskia Lee, Agnes Y Y Zuo, Fei da Costa, Bruno R Thorpe, Kevin E Negri, Elnara Márcia Cushman, Mary Jüni, Peter Laupacis, Andreas Lin, Yulia Day, Andrew Rochwerg, Bram Abdulrehman, Jameel Gergi, Mansour Kondo, Rodrigo Hidd Piloto, Bruna Mamprim de Abreu Pereira, Guilherme Valente, Fernando Salvetti Agreda, Ariel Fernando Villarroel Munoz Torres, Pablo Andres Moraes, Maíra Oliveira de Lucena Moreira, Claudia Neto, Fernando Galassi Stocco Baptista, Fabíola Vieira Duarte Moreira, Joanne Alves Ferreira, Augusto Séttemo Frudit, Paula Martinez, Gabriel Souza, Heraldo Possolo Neto, Rodrigo Antônio Brandão d'Amico, Elbio Antonio Padrão, Eduardo Messias Hirano Sarin da Mota e Albuquerque, Fernando Zangrossi, Giovanna Villela Kanasiro, Alberto Kendy Cincoto, Alissom Vitti de Souza Reis, Hugo Arias da Silva, Vitor Miyashiro Bellintani, Arthur Petrillo dos Santos Pereira, Vivian de Oliveira, Yohan Washington Carvalho, Bárbara Justo de Souza Novaes, Mariana Silveira, Henrique Brito de Avelar, Gabriel César Alves Mota, Lara Bonanni Caciola, Karina Marim, Matheus de Arêa Leão Freire Monsalvarga, Tales Cabral Blanco Santos, Alexandre Salgado Haydar, Ahmed Saraiva, Gabriella Seixas Sampaio da Costa Ribeiro, Sabrina Correa Meirelles Marchini, Julio Flavio de Alencar, Julio Cesar Garcia de Seixas Santos, Ana Catharina Millette, Caroline Lebeau, Mathieu Devaux, Céline Boutin, Mélina Nguyen, Trung Nghia Srour, Line de Angelis, Flavia Fugulin, Mariane Binnie, Alexandra Bejaimal, Shayna A.D. Binding, Andrew Marticorena, Rosa M. Ginocchio, Galo Kaplovitch, Eric Rymaszewski, Klaudia Raissi, Afsaneh Falappa, Marcelo Ernst, Blair Ali, Amna Romano, Martin Khurram, Mobina Kim, Christie Kapur, Ajay Edwards, Michelle Swarup, Vidushi Camilotti, Bruna Jani, Jiten Carter, Jeff Gillrie, Mark R. Sidhu, Davinder Robinson, Traci Stutely, Krystina Watpool, Irene Porteous, Rebecca Jao, Kevin Boudreault-Pedneault, Jean-Samuel Kandel, Christopher Taylor, Maureen T. Choo, Wei En Enoch Parsons, Laura Dowbenka, Ann Ramonas, Gitana Nikitin, Sergey Patterson, Jeffery Hnatiuk, Mark Tapardel, Anca Lapner, Sarah Takach Carpenter, Thirza Rackel, Lori Cairns, Rebecca Pinder, Jessica Anglin, Peter McPherson, Catherine Chiverton, Liselle Barbosa, David Loukiantchenko, Shany Shamiss, Yana Tassy, Danaë Shivakumar, Sudeep Keating, Mary-Margaret Pleasance, Sue Kevane, Barry Cullivan, Sarah Power, Nick Doran, Peter Leamy, Kelly Kelly, Aoife Moran, Conor O'Connor, Mairead McDonnell, Aoife Boyce, Roseanne Sefroun, Faiza Hussain, Rabia Murray, Patrick Malara, Anna Molloy, Brenda O’Halloran, Meadbh Cunningham, Emer Lambert, Jack Cotter, Aoife Marsh, Brian Sheehan, Gerard Muldoon, Eavan Woo, James Gaine, Sean Morley, Deirdre AlGahtani, Farjah H Almaghlouth, Ibrahim Ata, Sondus Alkhathlan, Fai Khalil, Najma Hussein, Israa Mohamed Bashir, Mohammed BaHammam, Ahmed S Alsultan, Abdulrahman Alkofide, Hadeel Alhawassi, Tariq M Alqahtani, Abdulhadi M. Zayed, Emad K. AlSughayir, Ammar Abuzied, Yacoub AlZahrani, Hazzaa Al-Otaibi, Jawaher Alothaimeen, Haya Alzannan, Noura Al Homssi, Amer Abid, Haisam Jones, Stephanie Broaddrick, Shannon Jain, Neha King, Roz Jindal, Mohit Sanfilippo, Kristen Nieters, Patty Hammad, Muhammad Benny, Aleeswa Francis Hamdan, Tariq A. Elobaid, Suhaib Kamal Ahmed Khafagi, Ibrahim Ahmed, Saima Saeed AlEssaie, AbduleRehman AlAlawi, Shamma Bashir, Khloud Al Suwaidi, Aysha Abdulla Salem Ahmed, Hiba Ibrahim Khogali Ismail, Mohamed Milad El Faki, El Mutasim Ahmed Charles, Mercy Dang, Alice Lakhanpal, Gurpreet Lee, Dominic Ray, Prachi Naydenova, Maria Wysocki, Kosma Jiwajee, Aziz Wendling, Greg Boyle, Rebekah Cornell, Elaine Mukaz, Debora Kamin BMJ Research OBJECTIVE: To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN: Randomised controlled, adaptive, open label clinical trial. SETTING: 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, United Arab Emirates, and US. PARTICIPANTS: 465 adults admitted to hospital wards with covid-19 and increased D-dimer levels were recruited between 29 May 2020 and 12 April 2021 and were randomly assigned to therapeutic dose heparin (n=228) or prophylactic dose heparin (n=237). INTERVENTIONS: Therapeutic dose or prophylactic dose heparin (low molecular weight or unfractionated heparin), to be continued until hospital discharge, day 28, or death. MAIN OUTCOME MEASURES: The primary outcome was a composite of death, invasive mechanical ventilation, non-invasive mechanical ventilation, or admission to an intensive care unit, assessed up to 28 days. The secondary outcomes included all cause death, the composite of all cause death or any mechanical ventilation, and venous thromboembolism. Safety outcomes included major bleeding. Outcomes were blindly adjudicated. RESULTS: The mean age of participants was 60 years; 264 (56.8%) were men and the mean body mass index was 30.3 kg/m(2). At 28 days, the primary composite outcome had occurred in 37/228 patients (16.2%) assigned to therapeutic heparin and 52/237 (21.9%) assigned to prophylactic heparin (odds ratio 0.69, 95% confidence interval 0.43 to 1.10; P=0.12). Deaths occurred in four patients (1.8%) assigned to therapeutic heparin and 18 patients (7.6%) assigned to prophylactic heparin (0.22, 0.07 to 0.65; P=0.006). The composite of all cause death or any mechanical ventilation occurred in 23 patients (10.1%) assigned to therapeutic heparin and 38 (16.0%) assigned to prophylactic heparin (0.59, 0.34 to 1.02; P=0.06). Venous thromboembolism occurred in two patients (0.9%) assigned to therapeutic heparin and six (2.5%) assigned to prophylactic heparin (0.34, 0.07 to 1.71; P=0.19). Major bleeding occurred in two patients (0.9%) assigned to therapeutic heparin and four (1.7%) assigned to prophylactic heparin (0.52, 0.09 to 2.85; P=0.69). CONCLUSIONS: In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital wards, therapeutic heparin was not significantly associated with a reduction in the primary outcome but the odds of death at 28 days was decreased. The risk of major bleeding appeared low in this trial. TRIAL REGISTRATION: ClinicalTrials.gov NCT04362085. BMJ Publishing Group Ltd. 2021-10-14 /pmc/articles/PMC8515466/ /pubmed/34649864 http://dx.doi.org/10.1136/bmj.n2400 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research
Sholzberg, Michelle
Tang, Grace H
Rahhal, Hassan
AlHamzah, Musaad
Kreuziger, Lisa Baumann
Áinle, Fionnuala Ní
Alomran, Faris
Alayed, Khalid
Alsheef, Mohammed
AlSumait, Fahad
Pompilio, Carlos Eduardo
Sperlich, Catherine
Tangri, Sabrena
Tang, Terence
Jaksa, Peter
Suryanarayan, Deepa
Almarshoodi, Mozah
Castellucci, Lana A
James, Paula D
Lillicrap, David
Carrier, Marc
Beckett, Andrew
Colovos, Christos
Jayakar, Jai
Arsenault, Marie-Pier
Wu, Cynthia
Doyon, Karine
Andreou, E Roseann
Dounaevskaia, Vera
Tseng, Eric K
Lim, Gloria
Fralick, Michael
Middeldorp, Saskia
Lee, Agnes Y Y
Zuo, Fei
da Costa, Bruno R
Thorpe, Kevin E
Negri, Elnara Márcia
Cushman, Mary
Jüni, Peter
Laupacis, Andreas
Lin, Yulia
Day, Andrew
Rochwerg, Bram
Abdulrehman, Jameel
Gergi, Mansour
Kondo, Rodrigo Hidd
Piloto, Bruna Mamprim
de Abreu Pereira, Guilherme
Valente, Fernando Salvetti
Agreda, Ariel Fernando Villarroel
Munoz Torres, Pablo Andres
Moraes, Maíra Oliveira
de Lucena Moreira, Claudia
Neto, Fernando Galassi Stocco
Baptista, Fabíola Vieira Duarte
Moreira, Joanne Alves
Ferreira, Augusto Séttemo
Frudit, Paula
Martinez, Gabriel
Souza, Heraldo Possolo
Neto, Rodrigo Antônio Brandão
d'Amico, Elbio Antonio
Padrão, Eduardo Messias Hirano
Sarin da Mota e Albuquerque, Fernando
Zangrossi, Giovanna Villela
Kanasiro, Alberto Kendy
Cincoto, Alissom Vitti
de Souza Reis, Hugo
Arias da Silva, Vitor Miyashiro
Bellintani, Arthur Petrillo
dos Santos Pereira, Vivian
de Oliveira, Yohan Washington
Carvalho, Bárbara Justo
de Souza Novaes, Mariana
Silveira, Henrique Brito
de Avelar, Gabriel César Alves
Mota, Lara Bonanni
Caciola, Karina
Marim, Matheus de Arêa Leão Freire
Monsalvarga, Tales Cabral
Blanco Santos, Alexandre Salgado
Haydar, Ahmed
Saraiva, Gabriella Seixas Sampaio
da Costa Ribeiro, Sabrina Correa
Meirelles Marchini, Julio Flavio
de Alencar, Julio Cesar Garcia
de Seixas Santos, Ana Catharina
Millette, Caroline
Lebeau, Mathieu
Devaux, Céline
Boutin, Mélina
Nguyen, Trung Nghia
Srour, Line
de Angelis, Flavia
Fugulin, Mariane
Binnie, Alexandra
Bejaimal, Shayna A.D.
Binding, Andrew
Marticorena, Rosa M.
Ginocchio, Galo
Kaplovitch, Eric
Rymaszewski, Klaudia
Raissi, Afsaneh
Falappa, Marcelo
Ernst, Blair
Ali, Amna
Romano, Martin
Khurram, Mobina
Kim, Christie
Kapur, Ajay
Edwards, Michelle
Swarup, Vidushi
Camilotti, Bruna
Jani, Jiten
Carter, Jeff
Gillrie, Mark R.
Sidhu, Davinder
Robinson, Traci
Stutely, Krystina
Watpool, Irene
Porteous, Rebecca
Jao, Kevin
Boudreault-Pedneault, Jean-Samuel
Kandel, Christopher
Taylor, Maureen T.
Choo, Wei En Enoch
Parsons, Laura
Dowbenka, Ann
Ramonas, Gitana
Nikitin, Sergey
Patterson, Jeffery
Hnatiuk, Mark
Tapardel, Anca
Lapner, Sarah Takach
Carpenter, Thirza
Rackel, Lori
Cairns, Rebecca
Pinder, Jessica
Anglin, Peter
McPherson, Catherine
Chiverton, Liselle
Barbosa, David
Loukiantchenko, Shany
Shamiss, Yana
Tassy, Danaë
Shivakumar, Sudeep
Keating, Mary-Margaret
Pleasance, Sue
Kevane, Barry
Cullivan, Sarah
Power, Nick
Doran, Peter
Leamy, Kelly
Kelly, Aoife
Moran, Conor
O'Connor, Mairead
McDonnell, Aoife
Boyce, Roseanne
Sefroun, Faiza
Hussain, Rabia
Murray, Patrick
Malara, Anna
Molloy, Brenda
O’Halloran, Meadbh
Cunningham, Emer
Lambert, Jack
Cotter, Aoife
Marsh, Brian
Sheehan, Gerard
Muldoon, Eavan
Woo, James
Gaine, Sean
Morley, Deirdre
AlGahtani, Farjah H
Almaghlouth, Ibrahim
Ata, Sondus
Alkhathlan, Fai
Khalil, Najma
Hussein, Israa Mohamed
Bashir, Mohammed
BaHammam, Ahmed S
Alsultan, Abdulrahman
Alkofide, Hadeel
Alhawassi, Tariq M
Alqahtani, Abdulhadi M.
Zayed, Emad K.
AlSughayir, Ammar
Abuzied, Yacoub
AlZahrani, Hazzaa
Al-Otaibi, Jawaher
Alothaimeen, Haya
Alzannan, Noura
Al Homssi, Amer
Abid, Haisam
Jones, Stephanie
Broaddrick, Shannon
Jain, Neha
King, Roz
Jindal, Mohit
Sanfilippo, Kristen
Nieters, Patty
Hammad, Muhammad
Benny, Aleeswa Francis
Hamdan, Tariq A.
Elobaid, Suhaib Kamal Ahmed
Khafagi, Ibrahim
Ahmed, Saima Saeed
AlEssaie, AbduleRehman
AlAlawi, Shamma
Bashir, Khloud
Al Suwaidi, Aysha Abdulla Salem
Ahmed, Hiba Ibrahim Khogali
Ismail, Mohamed Milad
El Faki, El Mutasim Ahmed
Charles, Mercy
Dang, Alice
Lakhanpal, Gurpreet
Lee, Dominic
Ray, Prachi
Naydenova, Maria
Wysocki, Kosma
Jiwajee, Aziz
Wendling, Greg
Boyle, Rebekah
Cornell, Elaine
Mukaz, Debora Kamin
Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
title Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
title_full Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
title_fullStr Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
title_full_unstemmed Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
title_short Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
title_sort effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: rapid randomised clinical trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515466/
https://www.ncbi.nlm.nih.gov/pubmed/34649864
http://dx.doi.org/10.1136/bmj.n2400
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AT deavelargabrielcesaralves effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT motalarabonanni effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT caciolakarina effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT marimmatheusdearealeaofreire effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT monsalvargatalescabral effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT blancosantosalexandresalgado effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT haydarahmed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT saraivagabriellaseixassampaio effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT dacostaribeirosabrinacorrea effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT meirellesmarchinijulioflavio effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT dealencarjuliocesargarcia effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT deseixassantosanacatharina effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT millettecaroline effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT lebeaumathieu effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT devauxceline effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT boutinmelina effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT nguyentrungnghia effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT srourline effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT deangelisflavia effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT fugulinmariane effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT binniealexandra effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT bejaimalshaynaad effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT bindingandrew effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT marticorenarosam effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT ginocchiogalo effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT kaplovitcheric effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT rymaszewskiklaudia effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT raissiafsaneh effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT falappamarcelo effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT ernstblair effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT aliamna effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT romanomartin effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT khurrammobina effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT kimchristie effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT kapurajay effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT edwardsmichelle effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT swarupvidushi effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT camilottibruna effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT janijiten effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT carterjeff effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT gillriemarkr effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT sidhudavinder effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT robinsontraci effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT stutelykrystina effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT watpoolirene effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT porteousrebecca effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT jaokevin effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT boudreaultpedneaultjeansamuel effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT kandelchristopher effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT taylormaureent effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT chooweienenoch effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT parsonslaura effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT dowbenkaann effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT ramonasgitana effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT nikitinsergey effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT pattersonjeffery effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT hnatiukmark effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT tapardelanca effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT lapnersarahtakach effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT carpenterthirza effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT rackellori effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT cairnsrebecca effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT pinderjessica effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT anglinpeter effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT mcphersoncatherine effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT chivertonliselle effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT barbosadavid effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT loukiantchenkoshany effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT shamissyana effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT tassydanae effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT shivakumarsudeep effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT keatingmarymargaret effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT pleasancesue effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT kevanebarry effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT cullivansarah effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT powernick effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT doranpeter effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT leamykelly effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT kellyaoife effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT moranconor effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT oconnormairead effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT mcdonnellaoife effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT boyceroseanne effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT sefrounfaiza effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT hussainrabia effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT murraypatrick effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT malaraanna effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT molloybrenda effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT ohalloranmeadbh effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT cunninghamemer effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT lambertjack effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT cotteraoife effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT marshbrian effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT sheehangerard effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT muldooneavan effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT woojames effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT gainesean effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT morleydeirdre effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT algahtanifarjahh effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT almaghlouthibrahim effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT atasondus effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alkhathlanfai effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT khalilnajma effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT husseinisraamohamed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT bashirmohammed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT bahammamahmeds effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alsultanabdulrahman effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alkofidehadeel effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alhawassitariqm effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alqahtaniabdulhadim effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT zayedemadk effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alsughayirammar effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT abuziedyacoub effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alzahranihazzaa effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alotaibijawaher effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alothaimeenhaya effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alzannannoura effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alhomssiamer effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT abidhaisam effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT jonesstephanie effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT broaddrickshannon effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT jainneha effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT kingroz effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT jindalmohit effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT sanfilippokristen effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT nieterspatty effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT hammadmuhammad effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT bennyaleeswafrancis effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT hamdantariqa effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT elobaidsuhaibkamalahmed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT khafagiibrahim effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT ahmedsaimasaeed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alessaieabdulerehman effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alalawishamma effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT bashirkhloud effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT alsuwaidiayshaabdullasalem effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT ahmedhibaibrahimkhogali effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT ismailmohamedmilad effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT elfakielmutasimahmed effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT charlesmercy effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT dangalice effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT lakhanpalgurpreet effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT leedominic effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT rayprachi effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT naydenovamaria effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT wysockikosma effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT jiwajeeaziz effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT wendlinggreg effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT boylerebekah effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT cornellelaine effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial
AT mukazdeborakamin effectivenessoftherapeuticheparinversusprophylacticheparinondeathmechanicalventilationorintensivecareunitadmissioninmoderatelyillpatientswithcovid19admittedtohospitalrapidrandomisedclinicaltrial