Tetraspanins: Host Factors in Viral Infections
Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583825/ https://www.ncbi.nlm.nih.gov/pubmed/34769038 http://dx.doi.org/10.3390/ijms222111609 |
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author | New, ChihSheng Lee, Zhao-Yong Tan, Kai Sen Wong, Amanda Huee-Ping Wang, De Yun Tran, Thai |
author_facet | New, ChihSheng Lee, Zhao-Yong Tan, Kai Sen Wong, Amanda Huee-Ping Wang, De Yun Tran, Thai |
author_sort | New, ChihSheng |
collection | PubMed |
description | Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases. |
format | Online Article Text |
id | pubmed-8583825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85838252021-11-12 Tetraspanins: Host Factors in Viral Infections New, ChihSheng Lee, Zhao-Yong Tan, Kai Sen Wong, Amanda Huee-Ping Wang, De Yun Tran, Thai Int J Mol Sci Review Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases. MDPI 2021-10-27 /pmc/articles/PMC8583825/ /pubmed/34769038 http://dx.doi.org/10.3390/ijms222111609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review New, ChihSheng Lee, Zhao-Yong Tan, Kai Sen Wong, Amanda Huee-Ping Wang, De Yun Tran, Thai Tetraspanins: Host Factors in Viral Infections |
title | Tetraspanins: Host Factors in Viral Infections |
title_full | Tetraspanins: Host Factors in Viral Infections |
title_fullStr | Tetraspanins: Host Factors in Viral Infections |
title_full_unstemmed | Tetraspanins: Host Factors in Viral Infections |
title_short | Tetraspanins: Host Factors in Viral Infections |
title_sort | tetraspanins: host factors in viral infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583825/ https://www.ncbi.nlm.nih.gov/pubmed/34769038 http://dx.doi.org/10.3390/ijms222111609 |
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