Tetraspanins: Host Factors in Viral Infections

Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza...

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Autores principales: New, ChihSheng, Lee, Zhao-Yong, Tan, Kai Sen, Wong, Amanda Huee-Ping, Wang, De Yun, Tran, Thai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583825/
https://www.ncbi.nlm.nih.gov/pubmed/34769038
http://dx.doi.org/10.3390/ijms222111609
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author New, ChihSheng
Lee, Zhao-Yong
Tan, Kai Sen
Wong, Amanda Huee-Ping
Wang, De Yun
Tran, Thai
author_facet New, ChihSheng
Lee, Zhao-Yong
Tan, Kai Sen
Wong, Amanda Huee-Ping
Wang, De Yun
Tran, Thai
author_sort New, ChihSheng
collection PubMed
description Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases.
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spelling pubmed-85838252021-11-12 Tetraspanins: Host Factors in Viral Infections New, ChihSheng Lee, Zhao-Yong Tan, Kai Sen Wong, Amanda Huee-Ping Wang, De Yun Tran, Thai Int J Mol Sci Review Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases. MDPI 2021-10-27 /pmc/articles/PMC8583825/ /pubmed/34769038 http://dx.doi.org/10.3390/ijms222111609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
New, ChihSheng
Lee, Zhao-Yong
Tan, Kai Sen
Wong, Amanda Huee-Ping
Wang, De Yun
Tran, Thai
Tetraspanins: Host Factors in Viral Infections
title Tetraspanins: Host Factors in Viral Infections
title_full Tetraspanins: Host Factors in Viral Infections
title_fullStr Tetraspanins: Host Factors in Viral Infections
title_full_unstemmed Tetraspanins: Host Factors in Viral Infections
title_short Tetraspanins: Host Factors in Viral Infections
title_sort tetraspanins: host factors in viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583825/
https://www.ncbi.nlm.nih.gov/pubmed/34769038
http://dx.doi.org/10.3390/ijms222111609
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