Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer
Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622516/ https://www.ncbi.nlm.nih.gov/pubmed/34833208 http://dx.doi.org/10.3390/polym13223909 |
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author | Kwan, Chak-Shing Ho, Watson K.-W. Chen, Yanyan Cai, Zongwei Leung, Ken Cham-Fai |
author_facet | Kwan, Chak-Shing Ho, Watson K.-W. Chen, Yanyan Cai, Zongwei Leung, Ken Cham-Fai |
author_sort | Kwan, Chak-Shing |
collection | PubMed |
description | Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 μM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials. |
format | Online Article Text |
id | pubmed-8622516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86225162021-11-27 Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer Kwan, Chak-Shing Ho, Watson K.-W. Chen, Yanyan Cai, Zongwei Leung, Ken Cham-Fai Polymers (Basel) Communication Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 μM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials. MDPI 2021-11-12 /pmc/articles/PMC8622516/ /pubmed/34833208 http://dx.doi.org/10.3390/polym13223909 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Kwan, Chak-Shing Ho, Watson K.-W. Chen, Yanyan Cai, Zongwei Leung, Ken Cham-Fai Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer |
title | Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer |
title_full | Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer |
title_fullStr | Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer |
title_full_unstemmed | Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer |
title_short | Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer |
title_sort | synthesis of functional building blocks for type iii-b rotaxane dendrimer |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622516/ https://www.ncbi.nlm.nih.gov/pubmed/34833208 http://dx.doi.org/10.3390/polym13223909 |
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