HIF-1α in cerebral ischemia
Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. H...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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D.A. Spandidos
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674706/ https://www.ncbi.nlm.nih.gov/pubmed/34878158 http://dx.doi.org/10.3892/mmr.2021.12557 |
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author | Dong, Peiliang Li, Qingna Han, Hua |
author_facet | Dong, Peiliang Li, Qingna Han, Hua |
author_sort | Dong, Peiliang |
collection | PubMed |
description | Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. HIF-1α is the main molecule that responds to hypoxia. HIF-1α serves an important role in the development of cerebral ischemia by participating in numerous processes, including metabolism, proliferation and angiogenesis. The present review focuses on the endogenous protective mechanism of cerebral ischemia and elaborates on the role of HIF-1α in cerebral ischemia. In addition, it focuses on cerebral ischemia interventions that act on the HIF-1α target, including biological factors, non-coding RNA, hypoxic-ischemic preconditioning and drugs, and expands upon the measures to strengthen the endogenous compensatory response to support HIF-1α as a therapeutic target, thus providing novel suggestions for the treatment of cerebral ischemia. |
format | Online Article Text |
id | pubmed-8674706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-86747062021-12-30 HIF-1α in cerebral ischemia Dong, Peiliang Li, Qingna Han, Hua Mol Med Rep Review Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. HIF-1α is the main molecule that responds to hypoxia. HIF-1α serves an important role in the development of cerebral ischemia by participating in numerous processes, including metabolism, proliferation and angiogenesis. The present review focuses on the endogenous protective mechanism of cerebral ischemia and elaborates on the role of HIF-1α in cerebral ischemia. In addition, it focuses on cerebral ischemia interventions that act on the HIF-1α target, including biological factors, non-coding RNA, hypoxic-ischemic preconditioning and drugs, and expands upon the measures to strengthen the endogenous compensatory response to support HIF-1α as a therapeutic target, thus providing novel suggestions for the treatment of cerebral ischemia. D.A. Spandidos 2022-02 2021-12-07 /pmc/articles/PMC8674706/ /pubmed/34878158 http://dx.doi.org/10.3892/mmr.2021.12557 Text en Copyright: © Dong et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Dong, Peiliang Li, Qingna Han, Hua HIF-1α in cerebral ischemia |
title | HIF-1α in cerebral ischemia |
title_full | HIF-1α in cerebral ischemia |
title_fullStr | HIF-1α in cerebral ischemia |
title_full_unstemmed | HIF-1α in cerebral ischemia |
title_short | HIF-1α in cerebral ischemia |
title_sort | hif-1α in cerebral ischemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674706/ https://www.ncbi.nlm.nih.gov/pubmed/34878158 http://dx.doi.org/10.3892/mmr.2021.12557 |
work_keys_str_mv | AT dongpeiliang hif1aincerebralischemia AT liqingna hif1aincerebralischemia AT hanhua hif1aincerebralischemia |