HIF-1α in cerebral ischemia

Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. H...

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Autores principales: Dong, Peiliang, Li, Qingna, Han, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674706/
https://www.ncbi.nlm.nih.gov/pubmed/34878158
http://dx.doi.org/10.3892/mmr.2021.12557
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author Dong, Peiliang
Li, Qingna
Han, Hua
author_facet Dong, Peiliang
Li, Qingna
Han, Hua
author_sort Dong, Peiliang
collection PubMed
description Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. HIF-1α is the main molecule that responds to hypoxia. HIF-1α serves an important role in the development of cerebral ischemia by participating in numerous processes, including metabolism, proliferation and angiogenesis. The present review focuses on the endogenous protective mechanism of cerebral ischemia and elaborates on the role of HIF-1α in cerebral ischemia. In addition, it focuses on cerebral ischemia interventions that act on the HIF-1α target, including biological factors, non-coding RNA, hypoxic-ischemic preconditioning and drugs, and expands upon the measures to strengthen the endogenous compensatory response to support HIF-1α as a therapeutic target, thus providing novel suggestions for the treatment of cerebral ischemia.
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spelling pubmed-86747062021-12-30 HIF-1α in cerebral ischemia Dong, Peiliang Li, Qingna Han, Hua Mol Med Rep Review Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. HIF-1α is the main molecule that responds to hypoxia. HIF-1α serves an important role in the development of cerebral ischemia by participating in numerous processes, including metabolism, proliferation and angiogenesis. The present review focuses on the endogenous protective mechanism of cerebral ischemia and elaborates on the role of HIF-1α in cerebral ischemia. In addition, it focuses on cerebral ischemia interventions that act on the HIF-1α target, including biological factors, non-coding RNA, hypoxic-ischemic preconditioning and drugs, and expands upon the measures to strengthen the endogenous compensatory response to support HIF-1α as a therapeutic target, thus providing novel suggestions for the treatment of cerebral ischemia. D.A. Spandidos 2022-02 2021-12-07 /pmc/articles/PMC8674706/ /pubmed/34878158 http://dx.doi.org/10.3892/mmr.2021.12557 Text en Copyright: © Dong et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Dong, Peiliang
Li, Qingna
Han, Hua
HIF-1α in cerebral ischemia
title HIF-1α in cerebral ischemia
title_full HIF-1α in cerebral ischemia
title_fullStr HIF-1α in cerebral ischemia
title_full_unstemmed HIF-1α in cerebral ischemia
title_short HIF-1α in cerebral ischemia
title_sort hif-1α in cerebral ischemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674706/
https://www.ncbi.nlm.nih.gov/pubmed/34878158
http://dx.doi.org/10.3892/mmr.2021.12557
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