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Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis

Inflammation is an intricate biological response of body tissues to detrimental stimuli. Cardiovascular disease (CVD) is the leading cause of death worldwide, and inflammation is well documented to play a role in the development of CVD, especially atherosclerosis (AS). Emerging evidence suggests tha...

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Detalles Bibliográficos
Autores principales: Jiang, Chunteng, Xie, Santuan, Yang, Guang, Wang, Ningning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711145/
https://www.ncbi.nlm.nih.gov/pubmed/34992411
http://dx.doi.org/10.2147/JIR.S344730
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author Jiang, Chunteng
Xie, Santuan
Yang, Guang
Wang, Ningning
author_facet Jiang, Chunteng
Xie, Santuan
Yang, Guang
Wang, Ningning
author_sort Jiang, Chunteng
collection PubMed
description Inflammation is an intricate biological response of body tissues to detrimental stimuli. Cardiovascular disease (CVD) is the leading cause of death worldwide, and inflammation is well documented to play a role in the development of CVD, especially atherosclerosis (AS). Emerging evidence suggests that activation of the NOD-like receptor (NLR) family and the pyridine-containing domain 3 (NLRP3) inflammasome is instrumental in inflammation and may result in AS. The NLRP3 inflammasome acts as a molecular platform that triggers the activation of caspase-1 and the cleavage of pro-interleukin (IL)-1β, pro-IL-18, and gasdermin D (GSDMD). The cleaved GSDMD forms pores in the cell membrane and initiates pyroptosis, inducing cell death and the discharge of intracellular pro-inflammatory factors. Hence, the NLRP3 inflammasome is a promising target for anti-inflammatory therapy against AS. In this review, we systematically summarized the current understanding of the activation mechanism of NLRP3 inflammasome, and the pathological changes in AS involving NLRP3. We also discussed potential therapeutic strategies targeting NLRP3 inflammasome to combat AS.
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spelling pubmed-87111452022-01-05 Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis Jiang, Chunteng Xie, Santuan Yang, Guang Wang, Ningning J Inflamm Res Review Inflammation is an intricate biological response of body tissues to detrimental stimuli. Cardiovascular disease (CVD) is the leading cause of death worldwide, and inflammation is well documented to play a role in the development of CVD, especially atherosclerosis (AS). Emerging evidence suggests that activation of the NOD-like receptor (NLR) family and the pyridine-containing domain 3 (NLRP3) inflammasome is instrumental in inflammation and may result in AS. The NLRP3 inflammasome acts as a molecular platform that triggers the activation of caspase-1 and the cleavage of pro-interleukin (IL)-1β, pro-IL-18, and gasdermin D (GSDMD). The cleaved GSDMD forms pores in the cell membrane and initiates pyroptosis, inducing cell death and the discharge of intracellular pro-inflammatory factors. Hence, the NLRP3 inflammasome is a promising target for anti-inflammatory therapy against AS. In this review, we systematically summarized the current understanding of the activation mechanism of NLRP3 inflammasome, and the pathological changes in AS involving NLRP3. We also discussed potential therapeutic strategies targeting NLRP3 inflammasome to combat AS. Dove 2021-12-21 /pmc/articles/PMC8711145/ /pubmed/34992411 http://dx.doi.org/10.2147/JIR.S344730 Text en © 2021 Jiang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Jiang, Chunteng
Xie, Santuan
Yang, Guang
Wang, Ningning
Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis
title Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis
title_full Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis
title_fullStr Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis
title_full_unstemmed Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis
title_short Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis
title_sort spotlight on nlrp3 inflammasome: role in pathogenesis and therapies of atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711145/
https://www.ncbi.nlm.nih.gov/pubmed/34992411
http://dx.doi.org/10.2147/JIR.S344730
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