Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma
PURPOSE: Ventricle contact is associated with a worse prognosis and more aggressive tumor characteristics in glioblastoma (GBM). This is hypothesized to be a result of neural stem cells located around the lateral ventricles, in the subventricular zone. 11C Methionine positron emission tomography (me...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789691/ https://www.ncbi.nlm.nih.gov/pubmed/34114063 http://dx.doi.org/10.1007/s00234-021-02742-7 |
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author | van Dijken, Bart R. J. Schuuring, Bram Jeltema, Hanne-Rinck van Laar, Peter Jan Enting, Roelien H. Dierckx, Rudi A. J. O. Stormezand, Gilles N. van der Hoorn, Anouk |
author_facet | van Dijken, Bart R. J. Schuuring, Bram Jeltema, Hanne-Rinck van Laar, Peter Jan Enting, Roelien H. Dierckx, Rudi A. J. O. Stormezand, Gilles N. van der Hoorn, Anouk |
author_sort | van Dijken, Bart R. J. |
collection | PubMed |
description | PURPOSE: Ventricle contact is associated with a worse prognosis and more aggressive tumor characteristics in glioblastoma (GBM). This is hypothesized to be a result of neural stem cells located around the lateral ventricles, in the subventricular zone. 11C Methionine positron emission tomography (metPET) is an indicator for increased proliferation, as it shows uptake of methionine, an amino acid needed for protein synthesis. This study is the first to study metPET characteristics of GBM in relation to ventricle contact. METHODS: A total of 12 patients with IDH wild-type GBM were included. Using MRI, the following regions were determined: primary tumor (defined as contrast enhancing lesion on T1) and peritumoral edema (defined as edema visible on FLAIR excluding the enhancement). PET parameters in these areas were extracted using PET fused with MRI imaging. Parameters extracted from the PET included maximum and mean tumor-to-normal ratio (TNRmax and TNRmean) and metabolic tumor volume (MTV). RESULTS: TNRmean of the primary tumor showed significantly higher values for the ventricle-contacting group compared to that for the non-contacting group (4.44 vs 2.67, p = 0.030). Other metPET parameters suggested higher values for the ventricle-contacting group, but these differences did not reach statistical significance. CONCLUSION: GBM with ventricle contact demonstrated a higher methionine uptake and might thus have increased proliferation compared with GBM without ventricle contact. This might explain survival differences and should be considered in treatment decisions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00234-021-02742-7. |
format | Online Article Text |
id | pubmed-8789691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-87896912022-02-02 Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma van Dijken, Bart R. J. Schuuring, Bram Jeltema, Hanne-Rinck van Laar, Peter Jan Enting, Roelien H. Dierckx, Rudi A. J. O. Stormezand, Gilles N. van der Hoorn, Anouk Neuroradiology Diagnostic Neuroradiology PURPOSE: Ventricle contact is associated with a worse prognosis and more aggressive tumor characteristics in glioblastoma (GBM). This is hypothesized to be a result of neural stem cells located around the lateral ventricles, in the subventricular zone. 11C Methionine positron emission tomography (metPET) is an indicator for increased proliferation, as it shows uptake of methionine, an amino acid needed for protein synthesis. This study is the first to study metPET characteristics of GBM in relation to ventricle contact. METHODS: A total of 12 patients with IDH wild-type GBM were included. Using MRI, the following regions were determined: primary tumor (defined as contrast enhancing lesion on T1) and peritumoral edema (defined as edema visible on FLAIR excluding the enhancement). PET parameters in these areas were extracted using PET fused with MRI imaging. Parameters extracted from the PET included maximum and mean tumor-to-normal ratio (TNRmax and TNRmean) and metabolic tumor volume (MTV). RESULTS: TNRmean of the primary tumor showed significantly higher values for the ventricle-contacting group compared to that for the non-contacting group (4.44 vs 2.67, p = 0.030). Other metPET parameters suggested higher values for the ventricle-contacting group, but these differences did not reach statistical significance. CONCLUSION: GBM with ventricle contact demonstrated a higher methionine uptake and might thus have increased proliferation compared with GBM without ventricle contact. This might explain survival differences and should be considered in treatment decisions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00234-021-02742-7. Springer Berlin Heidelberg 2021-06-10 2022 /pmc/articles/PMC8789691/ /pubmed/34114063 http://dx.doi.org/10.1007/s00234-021-02742-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Diagnostic Neuroradiology van Dijken, Bart R. J. Schuuring, Bram Jeltema, Hanne-Rinck van Laar, Peter Jan Enting, Roelien H. Dierckx, Rudi A. J. O. Stormezand, Gilles N. van der Hoorn, Anouk Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma |
title | Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma |
title_full | Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma |
title_fullStr | Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma |
title_full_unstemmed | Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma |
title_short | Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma |
title_sort | ventricle contact may be associated with higher 11c methionine pet uptake in glioblastoma |
topic | Diagnostic Neuroradiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789691/ https://www.ncbi.nlm.nih.gov/pubmed/34114063 http://dx.doi.org/10.1007/s00234-021-02742-7 |
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