Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants

Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Junsoo, Park, Rackhyun, Jang, Minsu, Park, Yea-In, Park, Yeonjeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Microbiological Society of Korea 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795716/
https://www.ncbi.nlm.nih.gov/pubmed/35089586
http://dx.doi.org/10.1007/s12275-022-1499-z
_version_ 1784641133381419008
author Park, Junsoo
Park, Rackhyun
Jang, Minsu
Park, Yea-In
Park, Yeonjeong
author_facet Park, Junsoo
Park, Rackhyun
Jang, Minsu
Park, Yea-In
Park, Yeonjeong
author_sort Park, Junsoo
collection PubMed
description Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNA-dependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds.
format Online
Article
Text
id pubmed-8795716
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Microbiological Society of Korea
record_format MEDLINE/PubMed
spelling pubmed-87957162022-01-28 Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants Park, Junsoo Park, Rackhyun Jang, Minsu Park, Yea-In Park, Yeonjeong J Microbiol Review Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNA-dependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds. The Microbiological Society of Korea 2022-01-28 2022 /pmc/articles/PMC8795716/ /pubmed/35089586 http://dx.doi.org/10.1007/s12275-022-1499-z Text en © The Microbiological Society of Korea 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Park, Junsoo
Park, Rackhyun
Jang, Minsu
Park, Yea-In
Park, Yeonjeong
Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
title Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
title_full Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
title_fullStr Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
title_full_unstemmed Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
title_short Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
title_sort coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795716/
https://www.ncbi.nlm.nih.gov/pubmed/35089586
http://dx.doi.org/10.1007/s12275-022-1499-z
work_keys_str_mv AT parkjunsoo coronavirusenzymeinhibitorsexperimentallyprovennaturalcompoundsfromplants
AT parkrackhyun coronavirusenzymeinhibitorsexperimentallyprovennaturalcompoundsfromplants
AT jangminsu coronavirusenzymeinhibitorsexperimentallyprovennaturalcompoundsfromplants
AT parkyeain coronavirusenzymeinhibitorsexperimentallyprovennaturalcompoundsfromplants
AT parkyeonjeong coronavirusenzymeinhibitorsexperimentallyprovennaturalcompoundsfromplants