Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Microbiological Society of Korea
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795716/ https://www.ncbi.nlm.nih.gov/pubmed/35089586 http://dx.doi.org/10.1007/s12275-022-1499-z |
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author | Park, Junsoo Park, Rackhyun Jang, Minsu Park, Yea-In Park, Yeonjeong |
author_facet | Park, Junsoo Park, Rackhyun Jang, Minsu Park, Yea-In Park, Yeonjeong |
author_sort | Park, Junsoo |
collection | PubMed |
description | Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNA-dependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds. |
format | Online Article Text |
id | pubmed-8795716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Microbiological Society of Korea |
record_format | MEDLINE/PubMed |
spelling | pubmed-87957162022-01-28 Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants Park, Junsoo Park, Rackhyun Jang, Minsu Park, Yea-In Park, Yeonjeong J Microbiol Review Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNA-dependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds. The Microbiological Society of Korea 2022-01-28 2022 /pmc/articles/PMC8795716/ /pubmed/35089586 http://dx.doi.org/10.1007/s12275-022-1499-z Text en © The Microbiological Society of Korea 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Park, Junsoo Park, Rackhyun Jang, Minsu Park, Yea-In Park, Yeonjeong Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
title | Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
title_full | Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
title_fullStr | Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
title_full_unstemmed | Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
title_short | Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
title_sort | coronavirus enzyme inhibitors-experimentally proven natural compounds from plants |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795716/ https://www.ncbi.nlm.nih.gov/pubmed/35089586 http://dx.doi.org/10.1007/s12275-022-1499-z |
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