The Protective Role of Celastrol in Renal Ischemia-Reperfusion Injury by Activating Nrf2/HO-1, PI3K/AKT Signaling Pathways, Modulating NF-κb Signaling Pathways, and Inhibiting ERK Phosphorylation

Celastrol, a natural triterpenoid derived from Tripterygium wilfordii, possesses numerous biological effects. We investigated celastrol’s antioxidant potential through nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) and its effect on phosphoinositide 3-kinase (PI3K)/protei...

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Detalles Bibliográficos
Autores principales: Younis, Nancy S., Ghanim, Amal M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881435/
https://www.ncbi.nlm.nih.gov/pubmed/35157199
http://dx.doi.org/10.1007/s12013-022-01064-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881435/
https://www.ncbi.nlm.nih.gov/pubmed/35157199
http://dx.doi.org/10.1007/s12013-022-01064-6

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