Histone Deacetylase 6 Inhibition Restores Leptin Sensitivity and Reduces Obesity
The adipose tissue-derived hormone leptin can drive decreases in food intake while increasing energy expenditure. In diet-induced obesity, circulating leptin levels rise proportionally to adiposity. Despite this hyperleptinemia, rodents and humans with obesity maintain increased adiposity and are re...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892841/ https://www.ncbi.nlm.nih.gov/pubmed/35039672 http://dx.doi.org/10.1038/s42255-021-00515-3 |