Interleukin-35 in autoimmune dermatoses: Current concepts

Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregu...

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Detalles Bibliográficos
Autores principales: Xie, Yuming, Zhang, Huilin, Huang, Junke, Zhang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941186/
https://www.ncbi.nlm.nih.gov/pubmed/35434379
http://dx.doi.org/10.1515/med-2022-0455
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author Xie, Yuming
Zhang, Huilin
Huang, Junke
Zhang, Qing
author_facet Xie, Yuming
Zhang, Huilin
Huang, Junke
Zhang, Qing
author_sort Xie, Yuming
collection PubMed
description Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregulatory functions of T cells, B cells, macrophages, and other immune cell types. Although there is currently limited research on the roles of IL-35 in human autoimmunity, many studies have demonstrated that IL-35 may mediate immunosuppression. Therefore, it plays an essential role in some autoimmune dermatoses, including systemic lupus erythematosus, psoriasis, systemic sclerosis, and dermatomyositis. We will introduce the structure and biological characteristics of IL-35 and summarize its effects on the occurrence and development of autoimmune dermatoses in this article. It is suggested that IL-35 is a possible target for therapy in the aforementioned diseases.
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spelling pubmed-89411862022-04-14 Interleukin-35 in autoimmune dermatoses: Current concepts Xie, Yuming Zhang, Huilin Huang, Junke Zhang, Qing Open Med (Wars) Review Article Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregulatory functions of T cells, B cells, macrophages, and other immune cell types. Although there is currently limited research on the roles of IL-35 in human autoimmunity, many studies have demonstrated that IL-35 may mediate immunosuppression. Therefore, it plays an essential role in some autoimmune dermatoses, including systemic lupus erythematosus, psoriasis, systemic sclerosis, and dermatomyositis. We will introduce the structure and biological characteristics of IL-35 and summarize its effects on the occurrence and development of autoimmune dermatoses in this article. It is suggested that IL-35 is a possible target for therapy in the aforementioned diseases. De Gruyter 2022-03-21 /pmc/articles/PMC8941186/ /pubmed/35434379 http://dx.doi.org/10.1515/med-2022-0455 Text en © 2022 Yuming Xie et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Review Article
Xie, Yuming
Zhang, Huilin
Huang, Junke
Zhang, Qing
Interleukin-35 in autoimmune dermatoses: Current concepts
title Interleukin-35 in autoimmune dermatoses: Current concepts
title_full Interleukin-35 in autoimmune dermatoses: Current concepts
title_fullStr Interleukin-35 in autoimmune dermatoses: Current concepts
title_full_unstemmed Interleukin-35 in autoimmune dermatoses: Current concepts
title_short Interleukin-35 in autoimmune dermatoses: Current concepts
title_sort interleukin-35 in autoimmune dermatoses: current concepts
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941186/
https://www.ncbi.nlm.nih.gov/pubmed/35434379
http://dx.doi.org/10.1515/med-2022-0455
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