Interleukin-35 in autoimmune dermatoses: Current concepts
Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941186/ https://www.ncbi.nlm.nih.gov/pubmed/35434379 http://dx.doi.org/10.1515/med-2022-0455 |
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author | Xie, Yuming Zhang, Huilin Huang, Junke Zhang, Qing |
author_facet | Xie, Yuming Zhang, Huilin Huang, Junke Zhang, Qing |
author_sort | Xie, Yuming |
collection | PubMed |
description | Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregulatory functions of T cells, B cells, macrophages, and other immune cell types. Although there is currently limited research on the roles of IL-35 in human autoimmunity, many studies have demonstrated that IL-35 may mediate immunosuppression. Therefore, it plays an essential role in some autoimmune dermatoses, including systemic lupus erythematosus, psoriasis, systemic sclerosis, and dermatomyositis. We will introduce the structure and biological characteristics of IL-35 and summarize its effects on the occurrence and development of autoimmune dermatoses in this article. It is suggested that IL-35 is a possible target for therapy in the aforementioned diseases. |
format | Online Article Text |
id | pubmed-8941186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-89411862022-04-14 Interleukin-35 in autoimmune dermatoses: Current concepts Xie, Yuming Zhang, Huilin Huang, Junke Zhang, Qing Open Med (Wars) Review Article Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregulatory functions of T cells, B cells, macrophages, and other immune cell types. Although there is currently limited research on the roles of IL-35 in human autoimmunity, many studies have demonstrated that IL-35 may mediate immunosuppression. Therefore, it plays an essential role in some autoimmune dermatoses, including systemic lupus erythematosus, psoriasis, systemic sclerosis, and dermatomyositis. We will introduce the structure and biological characteristics of IL-35 and summarize its effects on the occurrence and development of autoimmune dermatoses in this article. It is suggested that IL-35 is a possible target for therapy in the aforementioned diseases. De Gruyter 2022-03-21 /pmc/articles/PMC8941186/ /pubmed/35434379 http://dx.doi.org/10.1515/med-2022-0455 Text en © 2022 Yuming Xie et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Review Article Xie, Yuming Zhang, Huilin Huang, Junke Zhang, Qing Interleukin-35 in autoimmune dermatoses: Current concepts |
title | Interleukin-35 in autoimmune dermatoses: Current concepts |
title_full | Interleukin-35 in autoimmune dermatoses: Current concepts |
title_fullStr | Interleukin-35 in autoimmune dermatoses: Current concepts |
title_full_unstemmed | Interleukin-35 in autoimmune dermatoses: Current concepts |
title_short | Interleukin-35 in autoimmune dermatoses: Current concepts |
title_sort | interleukin-35 in autoimmune dermatoses: current concepts |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941186/ https://www.ncbi.nlm.nih.gov/pubmed/35434379 http://dx.doi.org/10.1515/med-2022-0455 |
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