Bimodal Expression Patterns, and Not Viral Burst Sizes, Predict the Effects of Vpr on HIV-1 Proviral Populations in Jurkat Cells

Integration site landscapes, clonal dynamics, and latency reversal with or without vpr were compared in HIV-1-infected Jurkat cell populations, and the properties of individual clones were defined. Clones differed in fractions of long terminal repeat (LTR)-active daughter cells, with some clones con...

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Detalles Bibliográficos
Autores principales: Atindaana, Edmond, Kissi-Twum, Abena, Emery, Sarah, Burnett, Cleo, Pitcher, Jake, Visser, Myra, Kidd, Jeffrey M., Telesnitsky, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040753/
https://www.ncbi.nlm.nih.gov/pubmed/35384697
http://dx.doi.org/10.1128/mbio.03748-21