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SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability

CD4(+) T cells are central to long-term immunity against viruses through the functions of T helper-1 (Th1) and T follicular helper (Tfh) cell subsets. To better understand the role of these subsets in COVID-19 immunity, we conducted a longitudinal study of SARS-CoV-2-specific CD4(+) T cell and antib...

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Autores principales: Nelson, Ryan W., Chen, Yuezhou, Venezia, Olivia L., Majerus, Richard M, Shin, Daniel S., Carrington, Mary N., Yu, Xu G., Wesemann, Duane R., Moon, James J., Luster, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097883/
https://www.ncbi.nlm.nih.gov/pubmed/35857584
http://dx.doi.org/10.1126/sciimmunol.abl9464
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author Nelson, Ryan W.
Chen, Yuezhou
Venezia, Olivia L.
Majerus, Richard M
Shin, Daniel S.
Carrington, Mary N.
Yu, Xu G.
Wesemann, Duane R.
Moon, James J.
Luster, Andrew D.
author_facet Nelson, Ryan W.
Chen, Yuezhou
Venezia, Olivia L.
Majerus, Richard M
Shin, Daniel S.
Carrington, Mary N.
Yu, Xu G.
Wesemann, Duane R.
Moon, James J.
Luster, Andrew D.
author_sort Nelson, Ryan W.
collection PubMed
description CD4(+) T cells are central to long-term immunity against viruses through the functions of T helper-1 (Th1) and T follicular helper (Tfh) cell subsets. To better understand the role of these subsets in COVID-19 immunity, we conducted a longitudinal study of SARS-CoV-2-specific CD4(+) T cell and antibody responses in convalescent subjects who seroconverted during the first wave of the pandemic in Boston, Massachusetts, United States, across a range of COVID-19 disease severities. Analyses of spike (S) and nucleocapsid (N) epitope-specific CD4(+) T cells using peptide and major histocompatibility complex class II (peptide:MHCII) tetramers demonstrated expanded populations of T cells recognizing the different SARS-CoV-2 epitopes in most subjects compared to pre-pandemic controls. Individuals who experienced a milder disease course not requiring hospitalization had a greater percentage of circulating Tfh (cTfh) and Th1 cells among SARS-CoV-2-specific cells. Analysis of SARS-CoV-2-specific CD4(+) T cells responses in a subset of individuals with sustained anti-S antibody responses following viral clearance also revealed an increased proportion of memory cTfh cells. Our findings indicate efficient early disease control also predicts favorable long-term adaptive immunity.
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spelling pubmed-90978832022-05-17 SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability Nelson, Ryan W. Chen, Yuezhou Venezia, Olivia L. Majerus, Richard M Shin, Daniel S. Carrington, Mary N. Yu, Xu G. Wesemann, Duane R. Moon, James J. Luster, Andrew D. Sci Immunol Research Articles CD4(+) T cells are central to long-term immunity against viruses through the functions of T helper-1 (Th1) and T follicular helper (Tfh) cell subsets. To better understand the role of these subsets in COVID-19 immunity, we conducted a longitudinal study of SARS-CoV-2-specific CD4(+) T cell and antibody responses in convalescent subjects who seroconverted during the first wave of the pandemic in Boston, Massachusetts, United States, across a range of COVID-19 disease severities. Analyses of spike (S) and nucleocapsid (N) epitope-specific CD4(+) T cells using peptide and major histocompatibility complex class II (peptide:MHCII) tetramers demonstrated expanded populations of T cells recognizing the different SARS-CoV-2 epitopes in most subjects compared to pre-pandemic controls. Individuals who experienced a milder disease course not requiring hospitalization had a greater percentage of circulating Tfh (cTfh) and Th1 cells among SARS-CoV-2-specific cells. Analysis of SARS-CoV-2-specific CD4(+) T cells responses in a subset of individuals with sustained anti-S antibody responses following viral clearance also revealed an increased proportion of memory cTfh cells. Our findings indicate efficient early disease control also predicts favorable long-term adaptive immunity. American Association for the Advancement of Science 2022-04-21 /pmc/articles/PMC9097883/ /pubmed/35857584 http://dx.doi.org/10.1126/sciimmunol.abl9464 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Nelson, Ryan W.
Chen, Yuezhou
Venezia, Olivia L.
Majerus, Richard M
Shin, Daniel S.
Carrington, Mary N.
Yu, Xu G.
Wesemann, Duane R.
Moon, James J.
Luster, Andrew D.
SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability
title SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability
title_full SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability
title_fullStr SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability
title_full_unstemmed SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability
title_short SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability
title_sort sars-cov-2 epitope-specific cd4(+) memory t cell responses across covid-19 disease severity and antibody durability
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097883/
https://www.ncbi.nlm.nih.gov/pubmed/35857584
http://dx.doi.org/10.1126/sciimmunol.abl9464
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