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SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability
CD4(+) T cells are central to long-term immunity against viruses through the functions of T helper-1 (Th1) and T follicular helper (Tfh) cell subsets. To better understand the role of these subsets in COVID-19 immunity, we conducted a longitudinal study of SARS-CoV-2-specific CD4(+) T cell and antib...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097883/ https://www.ncbi.nlm.nih.gov/pubmed/35857584 http://dx.doi.org/10.1126/sciimmunol.abl9464 |
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author | Nelson, Ryan W. Chen, Yuezhou Venezia, Olivia L. Majerus, Richard M Shin, Daniel S. Carrington, Mary N. Yu, Xu G. Wesemann, Duane R. Moon, James J. Luster, Andrew D. |
author_facet | Nelson, Ryan W. Chen, Yuezhou Venezia, Olivia L. Majerus, Richard M Shin, Daniel S. Carrington, Mary N. Yu, Xu G. Wesemann, Duane R. Moon, James J. Luster, Andrew D. |
author_sort | Nelson, Ryan W. |
collection | PubMed |
description | CD4(+) T cells are central to long-term immunity against viruses through the functions of T helper-1 (Th1) and T follicular helper (Tfh) cell subsets. To better understand the role of these subsets in COVID-19 immunity, we conducted a longitudinal study of SARS-CoV-2-specific CD4(+) T cell and antibody responses in convalescent subjects who seroconverted during the first wave of the pandemic in Boston, Massachusetts, United States, across a range of COVID-19 disease severities. Analyses of spike (S) and nucleocapsid (N) epitope-specific CD4(+) T cells using peptide and major histocompatibility complex class II (peptide:MHCII) tetramers demonstrated expanded populations of T cells recognizing the different SARS-CoV-2 epitopes in most subjects compared to pre-pandemic controls. Individuals who experienced a milder disease course not requiring hospitalization had a greater percentage of circulating Tfh (cTfh) and Th1 cells among SARS-CoV-2-specific cells. Analysis of SARS-CoV-2-specific CD4(+) T cells responses in a subset of individuals with sustained anti-S antibody responses following viral clearance also revealed an increased proportion of memory cTfh cells. Our findings indicate efficient early disease control also predicts favorable long-term adaptive immunity. |
format | Online Article Text |
id | pubmed-9097883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-90978832022-05-17 SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability Nelson, Ryan W. Chen, Yuezhou Venezia, Olivia L. Majerus, Richard M Shin, Daniel S. Carrington, Mary N. Yu, Xu G. Wesemann, Duane R. Moon, James J. Luster, Andrew D. Sci Immunol Research Articles CD4(+) T cells are central to long-term immunity against viruses through the functions of T helper-1 (Th1) and T follicular helper (Tfh) cell subsets. To better understand the role of these subsets in COVID-19 immunity, we conducted a longitudinal study of SARS-CoV-2-specific CD4(+) T cell and antibody responses in convalescent subjects who seroconverted during the first wave of the pandemic in Boston, Massachusetts, United States, across a range of COVID-19 disease severities. Analyses of spike (S) and nucleocapsid (N) epitope-specific CD4(+) T cells using peptide and major histocompatibility complex class II (peptide:MHCII) tetramers demonstrated expanded populations of T cells recognizing the different SARS-CoV-2 epitopes in most subjects compared to pre-pandemic controls. Individuals who experienced a milder disease course not requiring hospitalization had a greater percentage of circulating Tfh (cTfh) and Th1 cells among SARS-CoV-2-specific cells. Analysis of SARS-CoV-2-specific CD4(+) T cells responses in a subset of individuals with sustained anti-S antibody responses following viral clearance also revealed an increased proportion of memory cTfh cells. Our findings indicate efficient early disease control also predicts favorable long-term adaptive immunity. American Association for the Advancement of Science 2022-04-21 /pmc/articles/PMC9097883/ /pubmed/35857584 http://dx.doi.org/10.1126/sciimmunol.abl9464 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Nelson, Ryan W. Chen, Yuezhou Venezia, Olivia L. Majerus, Richard M Shin, Daniel S. Carrington, Mary N. Yu, Xu G. Wesemann, Duane R. Moon, James J. Luster, Andrew D. SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability |
title | SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability |
title_full | SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability |
title_fullStr | SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability |
title_full_unstemmed | SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability |
title_short | SARS-CoV-2 epitope-specific CD4(+) memory T cell responses across COVID-19 disease severity and antibody durability |
title_sort | sars-cov-2 epitope-specific cd4(+) memory t cell responses across covid-19 disease severity and antibody durability |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097883/ https://www.ncbi.nlm.nih.gov/pubmed/35857584 http://dx.doi.org/10.1126/sciimmunol.abl9464 |
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