Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations

BACKGROUND: While it has been known that human protein kinases mediate most signal transductions in cells and their dysfunction can result in inflammatory diseases and cancers, it remains a challenge to find effective kinase inhibitor as drugs for these diseases. One major challenge is the compensat...

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Detalles Bibliográficos
Autores principales: Fan, You-Wei, Liu, Wan-Hsin, Chen, Yun-Ti, Hsu, Yen-Chao, Pathak, Nikhil, Huang, Yu-Wei, Yang, Jinn-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208089/
https://www.ncbi.nlm.nih.gov/pubmed/35725381
http://dx.doi.org/10.1186/s12859-022-04760-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208089/
https://www.ncbi.nlm.nih.gov/pubmed/35725381
http://dx.doi.org/10.1186/s12859-022-04760-5

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