Genetic and Epigenetic Regulation of Brain Organoids

Revealing the mechanisms of neural development and the pathogenesis of neural diseases are one of the most challenging missions in life science. Pluripotent stem cells derived brain organoids mimic the development, maturation, signal generation, and function of human brains, providing unique advanta...

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Autores principales: Wang, You-Wei, Hu, Nan, Li, Xiao-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283755/
https://www.ncbi.nlm.nih.gov/pubmed/35846370
http://dx.doi.org/10.3389/fcell.2022.948818
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author Wang, You-Wei
Hu, Nan
Li, Xiao-Hong
author_facet Wang, You-Wei
Hu, Nan
Li, Xiao-Hong
author_sort Wang, You-Wei
collection PubMed
description Revealing the mechanisms of neural development and the pathogenesis of neural diseases are one of the most challenging missions in life science. Pluripotent stem cells derived brain organoids mimic the development, maturation, signal generation, and function of human brains, providing unique advantage for neurology. Single-cell RNA sequencing (scRNA-Seq) and multielectrode array independently revealed the similarity between brain organoids and immature human brain at early developmental stages, in the context of gene transcription and dynamic network of neuronal signals. Brain organoids provided the unique opportunity to investigate the underlying mechanism of neural differentiation, senescence, and pathogenesis. In this review, we summarized the latest knowledge and technology in the brain organoid field, the current and potential applications in disease models and pre-clinic studies, with emphasizing the importance of transcriptional and epigenetic analysis.
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spelling pubmed-92837552022-07-16 Genetic and Epigenetic Regulation of Brain Organoids Wang, You-Wei Hu, Nan Li, Xiao-Hong Front Cell Dev Biol Cell and Developmental Biology Revealing the mechanisms of neural development and the pathogenesis of neural diseases are one of the most challenging missions in life science. Pluripotent stem cells derived brain organoids mimic the development, maturation, signal generation, and function of human brains, providing unique advantage for neurology. Single-cell RNA sequencing (scRNA-Seq) and multielectrode array independently revealed the similarity between brain organoids and immature human brain at early developmental stages, in the context of gene transcription and dynamic network of neuronal signals. Brain organoids provided the unique opportunity to investigate the underlying mechanism of neural differentiation, senescence, and pathogenesis. In this review, we summarized the latest knowledge and technology in the brain organoid field, the current and potential applications in disease models and pre-clinic studies, with emphasizing the importance of transcriptional and epigenetic analysis. Frontiers Media S.A. 2022-07-01 /pmc/articles/PMC9283755/ /pubmed/35846370 http://dx.doi.org/10.3389/fcell.2022.948818 Text en Copyright © 2022 Wang, Hu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, You-Wei
Hu, Nan
Li, Xiao-Hong
Genetic and Epigenetic Regulation of Brain Organoids
title Genetic and Epigenetic Regulation of Brain Organoids
title_full Genetic and Epigenetic Regulation of Brain Organoids
title_fullStr Genetic and Epigenetic Regulation of Brain Organoids
title_full_unstemmed Genetic and Epigenetic Regulation of Brain Organoids
title_short Genetic and Epigenetic Regulation of Brain Organoids
title_sort genetic and epigenetic regulation of brain organoids
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283755/
https://www.ncbi.nlm.nih.gov/pubmed/35846370
http://dx.doi.org/10.3389/fcell.2022.948818
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