Is there a relationship between sleep apnoea and microalbuminuria?

INTRODUCTION: Obstructive sleep apnoea (OSA) is a cause of hypoxia, and the correlation between hypoxia and microvascular complications is well known. Microalbuminuria (MAU) is a marker for endovascular dysfunction and an indicator of cardiovascular events and all-cause mortality in the general popu...

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Autores principales: Cihanbeylerden, Melek, Yüceege, Melike Bağnu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418296/
https://www.ncbi.nlm.nih.gov/pubmed/34386891
http://dx.doi.org/10.1007/s11325-021-02461-6
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author Cihanbeylerden, Melek
Yüceege, Melike Bağnu
author_facet Cihanbeylerden, Melek
Yüceege, Melike Bağnu
author_sort Cihanbeylerden, Melek
collection PubMed
description INTRODUCTION: Obstructive sleep apnoea (OSA) is a cause of hypoxia, and the correlation between hypoxia and microvascular complications is well known. Microalbuminuria (MAU) is a marker for endovascular dysfunction and an indicator of cardiovascular events and all-cause mortality in the general population. The aim of this study was to investigate the relationship between microvascular damage and the metabolic complications of OSA based on the presence of MAU. MATERIAL AND METHOD: Urinary albumin/creatinine ratio (ACR) and microalbumin level were examined in patients with an apnoea-hypopnoea index (AHI) greater than 5/h (study group) and in patients with an AHI less than 5/h (control group). The exclusion criteria were other possible causes of MAU (hypertension, nephropathy, coronary artery disease, and severe thyroid dysfunction). RESULTS: Of 103 patients enrolled, 80 formed the group with OSA and 23 served as controls. According to the AHI values, the patients were divided into four groups as normal, mild, moderate and severe. There was no significant difference between the four groups in terms of the microalbumin level and urinary albumin/creatinine ratio. CONCLUSION: In this study, no significant relationship was found between MAU and sleep apnoea.
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spelling pubmed-94182962022-08-28 Is there a relationship between sleep apnoea and microalbuminuria? Cihanbeylerden, Melek Yüceege, Melike Bağnu Sleep Breath Hypoxia • Original Article INTRODUCTION: Obstructive sleep apnoea (OSA) is a cause of hypoxia, and the correlation between hypoxia and microvascular complications is well known. Microalbuminuria (MAU) is a marker for endovascular dysfunction and an indicator of cardiovascular events and all-cause mortality in the general population. The aim of this study was to investigate the relationship between microvascular damage and the metabolic complications of OSA based on the presence of MAU. MATERIAL AND METHOD: Urinary albumin/creatinine ratio (ACR) and microalbumin level were examined in patients with an apnoea-hypopnoea index (AHI) greater than 5/h (study group) and in patients with an AHI less than 5/h (control group). The exclusion criteria were other possible causes of MAU (hypertension, nephropathy, coronary artery disease, and severe thyroid dysfunction). RESULTS: Of 103 patients enrolled, 80 formed the group with OSA and 23 served as controls. According to the AHI values, the patients were divided into four groups as normal, mild, moderate and severe. There was no significant difference between the four groups in terms of the microalbumin level and urinary albumin/creatinine ratio. CONCLUSION: In this study, no significant relationship was found between MAU and sleep apnoea. Springer International Publishing 2021-08-13 2022 /pmc/articles/PMC9418296/ /pubmed/34386891 http://dx.doi.org/10.1007/s11325-021-02461-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Hypoxia • Original Article
Cihanbeylerden, Melek
Yüceege, Melike Bağnu
Is there a relationship between sleep apnoea and microalbuminuria?
title Is there a relationship between sleep apnoea and microalbuminuria?
title_full Is there a relationship between sleep apnoea and microalbuminuria?
title_fullStr Is there a relationship between sleep apnoea and microalbuminuria?
title_full_unstemmed Is there a relationship between sleep apnoea and microalbuminuria?
title_short Is there a relationship between sleep apnoea and microalbuminuria?
title_sort is there a relationship between sleep apnoea and microalbuminuria?
topic Hypoxia • Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418296/
https://www.ncbi.nlm.nih.gov/pubmed/34386891
http://dx.doi.org/10.1007/s11325-021-02461-6
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