TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells

A conditional knock-in mouse was generated in which the TAK1 catalytic subunit was largely replaced by the kinase-inactive TAK1[D175A] mutant in immune cells. The activation of p38α MAP kinase, c-Jun N-terminal kinases 1 and 2 (JNK1/2) and the canonical IKK complex induced by stimulation with severa...

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Detalles Bibliográficos
Autores principales: Rodrigues, Melissa, Petrova, Tsvetana, Tibbs, Brendan, Arthur, J. Simon C., Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Immunology & Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555797/
https://www.ncbi.nlm.nih.gov/pubmed/36062803
http://dx.doi.org/10.1042/BCJ20220314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555797/
https://www.ncbi.nlm.nih.gov/pubmed/36062803
http://dx.doi.org/10.1042/BCJ20220314

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