Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus

Detection of cytosolic DNA is a central element of the innate immunity system against viral infection. The Ku heterodimer, a component of the NHEJ pathway of DNA repair in the nucleus, functions as DNA sensor that detects dsDNA of viruses that replicate in the cytoplasm. Vaccinia virus expresses two...

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Detalles Bibliográficos
Autores principales: Rivera-Calzada, Angel, Arribas-Bosacoma, Raquel, Ruiz-Ramos, Alba, Escudero-Bravo, Paloma, Boskovic, Jasminka, Fernandez-Leiro, Rafael, Oliver, Antony W., Pearl, Laurence H., Llorca, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674614/
https://www.ncbi.nlm.nih.gov/pubmed/36400800
http://dx.doi.org/10.1038/s41467-022-34843-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674614/
https://www.ncbi.nlm.nih.gov/pubmed/36400800
http://dx.doi.org/10.1038/s41467-022-34843-z

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