A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China

BACKGROUND: With the rapid progress of high-throughput sequencing technology, characterization of schizophrenia (SZ) with underlying probing of the gut microbiome can explore pathogenic mechanisms, estimate disease risk, and allow customization of therapeutic and prophylactic modalities. In this stu...

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Autores principales: Yan, Fuyang, Xia, Lehong, Xu, Li, Deng, Liyun, Jin, Guolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694861/
https://www.ncbi.nlm.nih.gov/pubmed/36424595
http://dx.doi.org/10.1186/s12888-022-04328-w
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author Yan, Fuyang
Xia, Lehong
Xu, Li
Deng, Liyun
Jin, Guolin
author_facet Yan, Fuyang
Xia, Lehong
Xu, Li
Deng, Liyun
Jin, Guolin
author_sort Yan, Fuyang
collection PubMed
description BACKGROUND: With the rapid progress of high-throughput sequencing technology, characterization of schizophrenia (SZ) with underlying probing of the gut microbiome can explore pathogenic mechanisms, estimate disease risk, and allow customization of therapeutic and prophylactic modalities. In this study, we compared the differences in gut microbial diversity and composition between 50 SZ subjects and 50 healthy matched subjects in Zhejiang, China via targeted next-generation sequencing (16S rRNA amplicon). RESULTS: Accordingly, the alpha diversity indices (observed species index, Shannon index, and Simpson index) of the gut microbiome in the healthy control group were higher than those in the SZ group. Additionally, principal coordinate analysis and non-metric multidimensional scaling of beta diversity revealed that patients with SZ clustered more tightly than healthy controls. At the phylum level, we found that the abundance of Bacteroidetes and Proteobacteria in the SZ group was significantly increased. At the genus level, the relative abundances of Prevotella, Parabacteroides, and Sutterella were significantly higher, whereas the abundances of Faecalibacterium, Blautia, Lachnospira, Clostridium, Ruminococcus, and Coprococcus were lower than those in the healthy control group. Further analyses revealed that Succinivibrio, Megasphaera, and Nesterenkonia may serve as potential biomarkers for distinguishing patients with SZ from those in the control cohort. CONCLUSIONS: This study profiled differences in gut microbiome diversity, taxonomic composition, and function between SZ and healthy cohorts, and the insights from this research could be used to develop targeted next-generation sequencing-based diagnoses for SZ. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-022-04328-w.
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spelling pubmed-96948612022-11-26 A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China Yan, Fuyang Xia, Lehong Xu, Li Deng, Liyun Jin, Guolin BMC Psychiatry Research BACKGROUND: With the rapid progress of high-throughput sequencing technology, characterization of schizophrenia (SZ) with underlying probing of the gut microbiome can explore pathogenic mechanisms, estimate disease risk, and allow customization of therapeutic and prophylactic modalities. In this study, we compared the differences in gut microbial diversity and composition between 50 SZ subjects and 50 healthy matched subjects in Zhejiang, China via targeted next-generation sequencing (16S rRNA amplicon). RESULTS: Accordingly, the alpha diversity indices (observed species index, Shannon index, and Simpson index) of the gut microbiome in the healthy control group were higher than those in the SZ group. Additionally, principal coordinate analysis and non-metric multidimensional scaling of beta diversity revealed that patients with SZ clustered more tightly than healthy controls. At the phylum level, we found that the abundance of Bacteroidetes and Proteobacteria in the SZ group was significantly increased. At the genus level, the relative abundances of Prevotella, Parabacteroides, and Sutterella were significantly higher, whereas the abundances of Faecalibacterium, Blautia, Lachnospira, Clostridium, Ruminococcus, and Coprococcus were lower than those in the healthy control group. Further analyses revealed that Succinivibrio, Megasphaera, and Nesterenkonia may serve as potential biomarkers for distinguishing patients with SZ from those in the control cohort. CONCLUSIONS: This study profiled differences in gut microbiome diversity, taxonomic composition, and function between SZ and healthy cohorts, and the insights from this research could be used to develop targeted next-generation sequencing-based diagnoses for SZ. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-022-04328-w. BioMed Central 2022-11-24 /pmc/articles/PMC9694861/ /pubmed/36424595 http://dx.doi.org/10.1186/s12888-022-04328-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yan, Fuyang
Xia, Lehong
Xu, Li
Deng, Liyun
Jin, Guolin
A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China
title A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China
title_full A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China
title_fullStr A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China
title_full_unstemmed A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China
title_short A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China
title_sort comparative study to determine the association of gut microbiome with schizophrenia in zhejiang, china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694861/
https://www.ncbi.nlm.nih.gov/pubmed/36424595
http://dx.doi.org/10.1186/s12888-022-04328-w
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