Path Sampling Simulations Reveal How the Q61L Mutation Alters the Dynamics of KRas

[Image: see text] Flexibility is essential for many proteins to function, but can be difficult to characterize. Experiments lack resolution in space and time, while the time scales involved are prohibitively long for straightforward molecular dynamics simulations. In this work, we present a multiple...

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Detalles Bibliográficos
Autores principales: Roet, Sander, Hooft, Ferry, Bolhuis, Peter G., Swenson, David W. H., Vreede, Jocelyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743084/
https://www.ncbi.nlm.nih.gov/pubmed/36427204
http://dx.doi.org/10.1021/acs.jpcb.2c06235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743084/
https://www.ncbi.nlm.nih.gov/pubmed/36427204
http://dx.doi.org/10.1021/acs.jpcb.2c06235

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