HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia

Chronic hypoxia is a risk factor for Alzheimer’s disease (AD), and the neurofibrillary tangle (NFT) formed by hyperphosphorylated tau is one of the two major pathological changes in AD. However, the effect of chronic hypoxia on tau phosphorylation and its mechanism remains unclear. In this study, we...

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Detalles Bibliográficos
Autores principales: Lei, Ling, Feng, Jun, Wu, Gang, Wei, Zhen, Wang, Jian-Zhi, Zhang, Bin, Liu, Rong, Liu, Fei, Wang, Xiaochuan, Li, Hong-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783654/
https://www.ncbi.nlm.nih.gov/pubmed/36555780
http://dx.doi.org/10.3390/ijms232416140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783654/
https://www.ncbi.nlm.nih.gov/pubmed/36555780
http://dx.doi.org/10.3390/ijms232416140

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