From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis

Background: Sarcopenia is an age-related progressive, generalized skeletal muscle disorder involving the accelerated loss of muscle function and muscle mass. The aim of this study was to assess the complex relationship between sarcopenia, malnutrition, cognitive impairment, physical activity, and de...

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Autores principales: Ustevic, Cedomir, Rajovic, Nina, Stanisavljevic, Dejana, Tiosavljevic, Danijela, Pavlovic, Andrija, Tasic, Radica, Rajovic, Tatjana, Grupkovic, Jovana, Pilipovic, Filip, Pejin, Vedrana, Milcanovic, Petar, Mazic, Sanja, Milic, Natasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859183/
https://www.ncbi.nlm.nih.gov/pubmed/36673727
http://dx.doi.org/10.3390/ijerph20020972
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author Ustevic, Cedomir
Rajovic, Nina
Stanisavljevic, Dejana
Tiosavljevic, Danijela
Pavlovic, Andrija
Tasic, Radica
Rajovic, Tatjana
Grupkovic, Jovana
Pilipovic, Filip
Pejin, Vedrana
Milcanovic, Petar
Mazic, Sanja
Milic, Natasa
author_facet Ustevic, Cedomir
Rajovic, Nina
Stanisavljevic, Dejana
Tiosavljevic, Danijela
Pavlovic, Andrija
Tasic, Radica
Rajovic, Tatjana
Grupkovic, Jovana
Pilipovic, Filip
Pejin, Vedrana
Milcanovic, Petar
Mazic, Sanja
Milic, Natasa
author_sort Ustevic, Cedomir
collection PubMed
description Background: Sarcopenia is an age-related progressive, generalized skeletal muscle disorder involving the accelerated loss of muscle function and muscle mass. The aim of this study was to assess the complex relationship between sarcopenia, malnutrition, cognitive impairment, physical activity, and depression in the elderly, with the potential role of quality of life as a mediator in these associations. Methods: A cross-sectional study was conducted on a sample (n = 298) of elderly patients admitted to Special Hospital for Rehabilitation “Termal”, Vrdnik, Serbia. Sarcopenia, the risk for malnutrition, cognitive impairment, physical activity, quality of life, and depressive symptoms were measured by standardized instruments. Additional data included sociodemographic characteristics. Simultaneous assessment of the direct and indirect relationships of all determinants was performed by path analysis. Results: A total of 40% (n = 120) of the elderly were diagnosed with sarcopenia, and 42.6% had depression symptoms. The risk of malnutrition was present in 23.5%, cognitive impairment in 5.4%, and a low level of physical activity was reported in 26.2% of elderly participants. The mean reported quality of life measured by Sarcopenia and Quality of Life Questionnaire was 60 (on the scale ranging from 0 to 100; where a higher score reflects a higher quality of life). The best-fitted model (χ(2)/DF = 1.885, NFI = 0.987, CFI = 0.993, GFI = 0.997, RMSEA = 0.055) highlighted the mediating effect of quality of life between sarcopenia, malnutrition, cognitive impairment, lower level of physical activities and depression. According to the model, quality of life was a direct negative predictor of depressive symptoms in the elderly, while malnutrition positively affected depression. Conclusions: The presented path model may assist rehabilitation centers in developing strategies to screen for sarcopenia and risk of malnutrition, and promote physical activity in elderly, aiming to prevent their negative effects on mental health. For the elderly currently affected by sarcopenia, we consider regenerative medicine and stem cell therapy, which, in view of their etiology, could be a potential therapeutic strategy for sarcopenia.
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spelling pubmed-98591832023-01-21 From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis Ustevic, Cedomir Rajovic, Nina Stanisavljevic, Dejana Tiosavljevic, Danijela Pavlovic, Andrija Tasic, Radica Rajovic, Tatjana Grupkovic, Jovana Pilipovic, Filip Pejin, Vedrana Milcanovic, Petar Mazic, Sanja Milic, Natasa Int J Environ Res Public Health Article Background: Sarcopenia is an age-related progressive, generalized skeletal muscle disorder involving the accelerated loss of muscle function and muscle mass. The aim of this study was to assess the complex relationship between sarcopenia, malnutrition, cognitive impairment, physical activity, and depression in the elderly, with the potential role of quality of life as a mediator in these associations. Methods: A cross-sectional study was conducted on a sample (n = 298) of elderly patients admitted to Special Hospital for Rehabilitation “Termal”, Vrdnik, Serbia. Sarcopenia, the risk for malnutrition, cognitive impairment, physical activity, quality of life, and depressive symptoms were measured by standardized instruments. Additional data included sociodemographic characteristics. Simultaneous assessment of the direct and indirect relationships of all determinants was performed by path analysis. Results: A total of 40% (n = 120) of the elderly were diagnosed with sarcopenia, and 42.6% had depression symptoms. The risk of malnutrition was present in 23.5%, cognitive impairment in 5.4%, and a low level of physical activity was reported in 26.2% of elderly participants. The mean reported quality of life measured by Sarcopenia and Quality of Life Questionnaire was 60 (on the scale ranging from 0 to 100; where a higher score reflects a higher quality of life). The best-fitted model (χ(2)/DF = 1.885, NFI = 0.987, CFI = 0.993, GFI = 0.997, RMSEA = 0.055) highlighted the mediating effect of quality of life between sarcopenia, malnutrition, cognitive impairment, lower level of physical activities and depression. According to the model, quality of life was a direct negative predictor of depressive symptoms in the elderly, while malnutrition positively affected depression. Conclusions: The presented path model may assist rehabilitation centers in developing strategies to screen for sarcopenia and risk of malnutrition, and promote physical activity in elderly, aiming to prevent their negative effects on mental health. For the elderly currently affected by sarcopenia, we consider regenerative medicine and stem cell therapy, which, in view of their etiology, could be a potential therapeutic strategy for sarcopenia. MDPI 2023-01-05 /pmc/articles/PMC9859183/ /pubmed/36673727 http://dx.doi.org/10.3390/ijerph20020972 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ustevic, Cedomir
Rajovic, Nina
Stanisavljevic, Dejana
Tiosavljevic, Danijela
Pavlovic, Andrija
Tasic, Radica
Rajovic, Tatjana
Grupkovic, Jovana
Pilipovic, Filip
Pejin, Vedrana
Milcanovic, Petar
Mazic, Sanja
Milic, Natasa
From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis
title From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis
title_full From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis
title_fullStr From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis
title_full_unstemmed From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis
title_short From Sarcopenia to Depressive Symptoms in Elderly: A Path Analysis
title_sort from sarcopenia to depressive symptoms in elderly: a path analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859183/
https://www.ncbi.nlm.nih.gov/pubmed/36673727
http://dx.doi.org/10.3390/ijerph20020972
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